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Analysis of Epstein-Barr virus gene polymorphisms in normal donors and in
virus-associated tumors from different geographic locations
F Khanim, QY Yao, G Niedobitek, S Sihota, AB Rickinson and LS Young
Institute for Cancer Studies, University of Birmingham, CRC Institute for
Cancer Studies, U.K.
While Epstein-Barr virus (EBV) infection is associated with the development
of certain lymphoid and epithelial tumors, the role of the virus in the
pathogenesis of these malignancies remains unknown. It has been suggested
that EBV strain variation may contribute to tumor development. Two major
strains of EBV, type 1 and type 2, have been identified on the basis of
genetic polymorphisms and other minor genetic variations give rise to
distinct EBV isolates. We analyzed EBV strain variation in healthy
individuals and compared them with EBV isolates present in lymphoid and
epithelial neoplasms from the same geographic regions. In particular, the
incidence of the 30-bp latent membrane protein (LMP1) gene deletion,
recently implicated in the development of more aggressive forms of
virus-positive lymphomas and Hodgkin's disease [HD], was examined in the
normal population. While a preferential association of the LMP1 deletion
with the type 2 strain of EBV was observed, there was no increased
incidence of virus isolates carrying this deletion in HD, Burkitt's
lymphoma, or virus-associated carcinomas compared with the appropriate
normal population. A polymorphism in the BamHI F region of the EBV genome,
previously identified in Chinese populations, was found at increased
incidence in European HD biopsies. Overall, we found that most of the EBV
gene polymorphisms detected in EBV isolates from healthy virus carriers
occurred with similar frequency in virus-associated tumors from the same
geographical region.
Volume 88,
Issue 9,
pp. 3491-3501,
11/01/1996
Copyright © 1996 by The American Society of Hematology
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