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Migration of cells with immunoglobulin/c-myc recombinations in lymphoid
tissues of mice
JR Muller, GM Jones, S Janz and M Potter
Laboratory of Genetics, National Cancer Institute, National Institutes of
Health, Bethesda, MD 20892-4255, USA.
Recombinations between c-myc and immunoglobulin (Ig) sequences that
typically occur in pristane-induced mouse plasmacytomas were detected in
secondary lymphoid tissues from normal mice, chiefly in the gut- associated
lymphoid tissue. Based on the analysis of recombination sequences as
clonotypic markers, migration of c-myc recombination- positive cells was
observed between Peyer's patches and into the intestine. Treatment of
plasmacytoma-susceptible BALB/cAn mice with pristane induced proliferation
and migration of these cells into mesenteric lymph node, spleen, and oil
granuloma within 7 days. Plasmacytoma-resistant strains of mice (DBA/2N,
C3H/HeJ, C57BL/6) differed in that (1) they harbored fewer clones (Ig/c-myc
recombinations were detected in 33% of resistant mice versus 91% of
BALB/cAn mice after pristane treatment); (2) Ig/c-myc-positive cells were
rarely detected in the oil granuloma, and (3) c-myc recombined
predominantly with the Ig alpha locus in BALB/cAn mice (72%), but with the
Ig mu locus in DBA/2N and in C57BL/6 (67%). The results demonstrate that
normal mice generate a large number of lymphocytes with aberrant c- myc in
intestinal tissues without developing tumors.
Volume 89,
Issue 1,
pp. 291-296,
01/01/1997
Copyright © 1997 by The American Society of Hematology
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