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Major histocompatibility complex restriction between hematopoietic stem
cells and stromal cells in vivo
F Hashimoto, K Sugiura, K Inoue and S Ikehara
First Department of Pathology, Kansai Medical University, Osaka, Japan.
Graft failure is a mortal complication in allogeneic bone marrow
transplantation (BMT); T cells and natural killer cells are responsible for
graft rejection. However, we have recently demonstrated that the
recruitment of donor-derived stromal cells prevents graft failure in
allogeneic BMT. This finding prompted us to examine whether a major
histocompatibility complex (MHC) restriction exists between hematopoietic
stem cells (HSCs) and stromal cells. We transplanted bone marrow cells
(BMCs) and bones obtained from various mouse strains and analyzed the cells
that accumulated in the engrafted bones. Statistically significant cell
accumulation was found in the engrafted bone, which had the same H-2
phenotype as that of the BMCs, whereas only few cells were detected in the
engrafted bones of the third-party H-2 phenotypes during the 4 to 6 weeks
after BMT. Moreover, the BMCs obtained from the MHC-compatible bone showed
significant numbers of both colony-forming units in culture (CFU-C) and
spleen colony-forming units (CFU-S). These findings strongly suggest that
an MHC restriction exists between HSCs and stromal cells.
Volume 89,
Issue 1,
pp. 49-54,
01/01/1997
Copyright © 1997 by The American Society of Hematology
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