SEARCH:   Advanced

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tsai, F.-Y. Articles by Orkin, S. H. Search for Related Content PubMed PubMed Citation Articles by Tsai, F.-Y. Articles by Orkin, S. H. Related Collections Hematopoiesis and Stem Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation FY Tsai and SH Orkin Division of Hematology/Oncology and Howard Hughes Medical Institute, Children's Hospital, and Harvard Medical School, Boston, MA 02115, USA. The zinc-finger transcription factor GATA-2 plays a critical role in maintaining the pool of early hematopoietic cells. To define its specific functions in the proliferation, survival, and differentiation of hematopoietic cells, we analyzed the hematopoietic potential of GATA- 2-/- cells in in vitro culture systems for proliferation and maintenance of uncommitted progenitors or differentiation of specific lineages. From a two-step in vitro differentiation assay of embryonic stem cells and in vitro culture of yolk sac cells, we demonstrate that GATA-2 is required for the expansion of multipotential hematopoietic progenitors and the formation of mast cells, but dispensable for the terminal differentiation of erythroid cells and macrophages. The rare GATA-2-/- multipotential progenitors that survive proliferate poorly and generate small colonies with extensive cell death, implying that GATA-2 may play a role in both the proliferation and survival of early hematopoietic cells. To explore possible mechanisms resulting in the hematopoietic defects of GATA-2-/- cells, we interbred mutant mouse strains to assess the effects of p53 loss on the behavior of GATA-2-/- hematopoietic cells. Analysis of GATA-2-/-/p53-/- compound-mutant embryos shows that the absence of p53 partially restores the number of total GATA-2-/- hematopoietic cells, and therefore suggests a potential link between GATA-2 and p53 pathways. Volume 89, Issue 10, pp. 3636-3643, 05/15/1997 Copyright © 1997 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Gao, X. Wu, and N. Fossett Upregulation of the Drosophila Friend of GATA Gene u-shaped by JAK/STAT Signaling Maintains Lymph Gland Prohemocyte Potency Mol. Cell. Biol., November 15, 2009; 29(22): 6086 - 6096. [Abstract] [Full Text] [PDF] H. Song, J.-i. Suehiro, Y. Kanki, Y. Kawai, K. Inoue, H. Daida, K. Yano, T. Ohhashi, P. Oettgen, W. C. Aird, et al. Critical Role for GATA3 in Mediating Tie2 Expression and Function in Large Vessel Endothelial Cells J. Biol. Chem., October 16, 2009; 284(42): 29109 - 29124. [Abstract] [Full Text] [PDF] P. Home, S. Ray, D. Dutta, I. Bronshteyn, M. Larson, and S. Paul GATA3 Is Selectively Expressed in the Trophectoderm of Peri-implantation Embryo and Directly Regulates Cdx2 Gene Expression J. Biol. Chem., October 16, 2009; 284(42): 28729 - 28737. [Abstract] [Full Text] [PDF] Z. Huang, L. C. Dore, Z. Li, S. H. Orkin, G. Feng, S. Lin, and J. D. Crispino GATA-2 Reinforces Megakaryocyte Development in the Absence of GATA-1 Mol. Cell. Biol., September 15, 2009; 29(18): 5168 - 5180. [Abstract] [Full Text] [PDF] S. T. Chou, E. Khandros, L. C. Bailey, K. E. Nichols, C. R. Vakoc, Y. Yao, Z. Huang, J. D. Crispino, R. C. Hardison, G. A. Blobel, et al. Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate Blood, July 30, 2009; 114(5): 983 - 994. [Abstract] [Full Text] [PDF] H. Tang, S. Chen, H. Wang, H. Wu, Q. Lu, and D. Han TAM receptors and the regulation of erythropoiesis in mice Haematologica, March 1, 2009; 94(3): 326 - 334. [Abstract] [Full Text] [PDF] R. J. Mayoral, M. E. Pipkin, M. Pachkov, E. van Nimwegen, A. Rao, and S. Monticelli MicroRNA-221-222 Regulate the Cell Cycle in Mast Cells J. Immunol., January 1, 2009; 182(1): 433 - 445. [Abstract] [Full Text] [PDF] N. P. Rodrigues, A. S. Boyd, C. Fugazza, G. E. May, Y. Guo, A. J. Tipping, D. T. Scadden, P. Vyas, and T. Enver GATA-2 regulates granulocyte-macrophage progenitor cell function Blood, December 15, 2008; 112(13): 4862 - 4873. [Abstract] [Full Text] [PDF] R. J. Wozniak, S. Keles, J. J. Lugus, K. H. Young, M. E. Boyer, T. M. Tran, K. Choi, and E. H. Bresnick Molecular Hallmarks of Endogenous Chromatin Complexes Containing Master Regulators of Hematopoiesis Mol. Cell. Biol., November 1, 2008; 28(21): 6681 - 6694. [Abstract] [Full Text] [PDF] A. Rojas, S. W. Kong, P. Agarwal, B. Gilliss, W. T. Pu, and B. L. Black GATA4 Is a Direct Transcriptional Activator of Cyclin D2 and Cdk4 and Is Required for Cardiomyocyte Proliferation in Anterior Heart Field-Derived Myocardium Mol. Cell. Biol., September 1, 2008; 28(17): 5420 - 5431. [Abstract] [Full Text] [PDF] J.-i. Kashiwakura, W. Xiao, J. Kitaura, Y. Kawakami, M. Maeda-Yamamoto, J. R. Pfeiffer, B. S. Wilson, U. Blank, and T. Kawakami Pivotal Advance: IgE accelerates in vitro development of mast cells and modifies their phenotype J. Leukoc. Biol., August 1, 2008; 84(2): 357 - 367. [Abstract] [Full Text] [PDF] M. Sakata-Yanagimoto, E. Nakagami-Yamaguchi, T. Saito, K. Kumano, K. Yasutomo, S. Ogawa, M. Kurokawa, and S. Chiba From the Cover: Coordinated regulation of transcription factors through Notch2 is an important mediator of mast cell fate PNAS, June 3, 2008; 105(22): 7839 - 7844. [Abstract] [Full Text] [PDF] S. L. McKinney-Freeman, C. Lengerke, I.-H. Jang, S. Schmitt, Y. Wang, M. Philitas, J. Shea, and G. Q. Daley Modulation of murine embryonic stem cell-derived CD41+c-kit+ hematopoietic progenitors by ectopic expression of Cdx genes Blood, May 15, 2008; 111(10): 4944 - 4953. [Abstract] [Full Text] [PDF] W. Brandt, M. Khandekar, N. Suzuki, M. Yamamoto, K.-C. Lim, and J. D. Engel Defining the Functional Boundaries of the Gata2 Locus by Rescue with a Linked Bacterial Artificial Chromosome Transgene J. Biol. Chem., April 4, 2008; 283(14): 8976 - 8983. [Abstract] [Full Text] [PDF] A. B. Cantor, H. Iwasaki, Y. Arinobu, T. B. Moran, H. Shigematsu, M. R. Sullivan, K. Akashi, and S. H. Orkin Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage J. Exp. Med., March 17, 2008; 205(3): 611 - 624. [Abstract] [Full Text] [PDF] J.-R. Landry, S. Kinston, K. Knezevic, M. F.T.R. de Bruijn, N. Wilson, W. T. Nottingham, M. Peitz, F. Edenhofer, J. E. Pimanda, K. Ottersbach, et al. Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver Blood, March 15, 2008; 111(6): 3005 - 3014. [Abstract] [Full Text] [PDF] L. C. Dore, J. D. Amigo, C. O. dos Santos, Z. Zhang, X. Gai, J. W. Tobias, D. Yu, A. M. Klein, C. Dorman, W. Wu, et al. A GATA-1-regulated microRNA locus essential for erythropoiesis PNAS, March 4, 2008; 105(9): 3333 - 3338. [Abstract] [Full Text] [PDF] D. Sugiyama, M. Tanaka, K. Kitajima, J. Zheng, H. Yen, T. Murotani, A. Yamatodani, and T. Nakano Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation Blood, February 15, 2008; 111(4): 1924 - 1932. [Abstract] [Full Text] [PDF] J. M. Salmon, N. J. Slater, M. A. Hall, M. P. McCormack, S. L. Nutt, S. M. Jane, and D. J. Curtis Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene Blood, November 15, 2007; 110(10): 3573 - 3581. [Abstract] [Full Text] [PDF] Y. Chen, P. Haviernik, K. D. Bunting, and Y.-C. Yang Cited2 is required for normal hematopoiesis in the murine fetal liver Blood, October 15, 2007; 110(8): 2889 - 2898. [Abstract] [Full Text] [PDF] L. Gutierrez, T. Nikolic, T. B. van Dijk, H. Hammad, N. Vos, M. Willart, F. Grosveld, S. Philipsen, and B. N. Lambrecht Gata1 regulates dendritic-cell development and survival Blood, September 15, 2007; 110(6): 1933 - 1941. [Abstract] [Full Text] [PDF] M. Kobayashi and M. Yamamoto Regulation of GATA1 Gene Expression J. Biochem., July 1, 2007; 142(1): 1 - 10. [Abstract] [Full Text] [PDF] S.-I. Kim, S. J. Bultman, H. Jing, G. A. Blobel, and E. H. Bresnick Dissecting Molecular Steps in Chromatin Domain Activation during Hematopoietic Differentiation Mol. Cell. Biol., June 15, 2007; 27(12): 4551 - 4565. [Abstract] [Full Text] [PDF] S. Koga, N. Yamaguchi, T. Abe, M. Minegishi, S. Tsuchiya, M. Yamamoto, and N. Minegishi Cell-cycle-dependent oscillation of GATA2 expression in hematopoietic cells Blood, May 15, 2007; 109(10): 4200 - 4208. [Abstract] [Full Text] [PDF] R. J. Wozniak, M. E. Boyer, J. A. Grass, Y. Lee, and E. H. Bresnick Context-dependent GATA Factor Function: COMBINATORIAL REQUIREMENTS FOR TRANSCRIPTIONAL CONTROL IN HEMATOPOIETIC AND ENDOTHELIAL CELLS J. Biol. Chem., May 11, 2007; 282(19): 14665 - 14674. [Abstract] [Full Text] [PDF] M. Khandekar, W. Brandt, Y. Zhou, S. Dagenais, T. W. Glover, N. Suzuki, R. Shimizu, M. Yamamoto, K.-C. Lim, and J. D. Engel A Gata2 intronic enhancer confers its pan-endothelia-specific regulation Development, May 1, 2007; 134(9): 1703 - 1712. [Abstract] [Full Text] [PDF] J. J. Lugus, Y. S. Chung, J. C. Mills, S.-I. Kim, J. A. Grass, M. Kyba, J. M. Doherty, E. H. Bresnick, and K. Choi GATA2 functions at multiple steps in hemangioblast development and differentiation Development, January 15, 2007; 134(2): 393 - 405. [Abstract] [Full Text] [PDF] A. Masuda, K. Hashimoto, T. Yokoi, T. Doi, T. Kodama, H. Kume, K. Ohno, and T. Matsuguchi Essential Role of GATA Transcriptional Factors in the Activation of Mast Cells J. Immunol., January 1, 2007; 178(1): 360 - 368. [Abstract] [Full Text] [PDF] A. H. Shahlaee, S. Brandal, Y.-N. Lee, C. Jie, and C. M. Takemoto Distinct and Shared Transcriptomes Are Regulated by Microphthalmia-Associated Transcription Factor Isoforms in Mast Cells J. Immunol., January 1, 2007; 178(1): 378 - 388. [Abstract] [Full Text] [PDF] M. L. Martowicz, J. A. Grass, and E. H. Bresnick GATA-1-mediated Transcriptional Repression Yields Persistent Transcription Factor IIB-Chromatin Complexes J. Biol. Chem., December 8, 2006; 281(49): 37345 - 37352. [Abstract] [Full Text] [PDF] H. Iwasaki, S.-i. Mizuno, Y. Arinobu, H. Ozawa, Y. Mori, H. Shigematsu, K. Takatsu, D. G. Tenen, and K. Akashi The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. Genes & Dev., November 1, 2006; 20(21): 3010 - 3021. [Abstract] [Full Text] [PDF] K. D. Johnson, S.-I. Kim, and E. H. Bresnick Differential sensitivities of transcription factor target genes underlie cell type-specific gene expression profiles PNAS, October 24, 2006; 103(43): 15939 - 15944. [Abstract] [Full Text] [PDF] L. Laricchia-Robbio, R. Fazzina, D. Li, C. R. Rinaldi, K. K. Sinha, S. Chakraborty, and G. Nucifora Point Mutations in Two EVI1 Zn Fingers Abolish EVI1-GATA1 Interaction and Allow Erythroid Differentiation of Murine Bone Marrow Cells Mol. Cell. Biol., October 15, 2006; 26(20): 7658 - 7666. [Abstract] [Full Text] [PDF] J. A. Grass, H. Jing, S.-I. Kim, M. L. Martowicz, S. Pal, G. A. Blobel, and E. H. Bresnick Distinct Functions of Dispersed GATA Factor Complexes at an Endogenous Gene Locus. Mol. Cell. Biol., October 1, 2006; 26(19): 7056 - 7067. [Abstract] [Full Text] [PDF] Z. Yuan, A. Tie, M. Tarnopolsky, and M. Bakovic Genomic organization, promoter activity, and expression of the human choline transporter-like protein 1 Physiol Genomics, September 14, 2006; 26(1): 76 - 90. [Abstract] [Full Text] [PDF] A. Vegiopoulos, P. Garcia, N. Emambokus, and J. Frampton Coordination of erythropoiesis by the transcription factor c-Myb Blood, June 15, 2006; 107(12): 4703 - 4710. [Abstract] [Full Text] [PDF] M. A. Charles, T. L. Saunders, W. M. Wood, K. Owens, A. F. Parlow, S. A. Camper, E. C. Ridgway, and D. F. Gordon Pituitary-Specific Gata2 Knockout: Effects on Gonadotrope and Thyrotrope Function Mol. Endocrinol., June 1, 2006; 20(6): 1366 - 1377. [Abstract] [Full Text] [PDF] R. F. de Pooter, T. M. Schmitt, J. L. de la Pompa, Y. Fujiwara, S. H. Orkin, and J. C. Zuniga-Pflucker Notch Signaling Requires GATA-2 to Inhibit Myelopoiesis from Embryonic Stem Cells and Primary Hemopoietic Progenitors J. Immunol., May 1, 2006; 176(9): 5267 - 5275. [Abstract] [Full Text] [PDF] K. Kitajima, M. Tanaka, J. Zheng, H. Yen, A. Sato, D. Sugiyama, H. Umehara, E. Sakai, and T. Nakano Redirecting differentiation of hematopoietic progenitors by a transcription factor, GATA-2 Blood, March 1, 2006; 107(5): 1857 - 1863. [Abstract] [Full Text] [PDF] N. Suzuki, O. Ohneda, N. Minegishi, M. Nishikawa, T. Ohta, S. Takahashi, J. D. Engel, and M. Yamamoto Combinatorial Gata2 and Sca1 expression defines hematopoietic stem cells in the bone marrow niche PNAS, February 14, 2006; 103(7): 2202 - 2207. [Abstract] [Full Text] [PDF] D. C. Tang, J. Zhu, W. Liu, K. Chin, J. Sun, L. Chen, J. A. Hanover, and G. P. Rodgers The hydroxyurea-induced small GTP-binding protein SAR modulates {gamma}-globin gene expression in human erythroid cells Blood, November 1, 2005; 106(9): 3256 - 3263. [Abstract] [Full Text] [PDF] N. P. Rodrigues, V. Janzen, R. Forkert, D. M. Dombkowski, A. S. Boyd, S. H. Orkin, T. Enver, P. Vyas, and D. T. Scadden Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis Blood, July 15, 2005; 106(2): 477 - 484. [Abstract] [Full Text] [PDF] N. Minegishi, N. Suzuki, Y. Kawatani, R. Shimizu, and M. Yamamoto Rapid turnover of GATA-2 via ubiquitin-proteasome protein degradation pathway Genes Cells, July 1, 2005; 10(7): 693 - 704. [Abstract] [Full Text] [PDF] S. Ezoe, I. Matsumura, K. Gale, Y. Satoh, J. Ishikawa, M. Mizuki, S. Takahashi, N. Minegishi, K. Nakajima, M. Yamamoto, et al. GATA Transcription Factors Inhibit Cytokine-dependent Growth and Survival of a Hematopoietic Cell Line through the Inhibition of STAT3 Activity J. Biol. Chem., April 1, 2005; 280(13): 13163 - 13170. [Abstract] [Full Text] [PDF] A. Robert-Moreno, L. Espinosa, J. L. de la Pompa, and A. Bigas RBPj{kappa}-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells Development, March 1, 2005; 132(5): 1117 - 1126. [Abstract] [Full Text] [PDF] A. I. Marusina, D.-K. Kim, L. D. Lieto, F. Borrego, and J. E. Coligan GATA-3 Is an Important Transcription Factor for Regulating Human NKG2A Gene Expression J. Immunol., February 15, 2005; 174(4): 2152 - 2159. [Abstract] [Full Text] [PDF] M. L. Martowicz, J. A. Grass, M. E. Boyer, H. Guend, and E. H. Bresnick Dynamic GATA Factor Interplay at a Multicomponent Regulatory Region of the GATA-2 Locus J. Biol. Chem., January 21, 2005; 280(3): 1724 - 1732. [Abstract] [Full Text] [PDF] M. J. Nemeth, A. P. Cline, S. M. Anderson, L. J. Garrett-Beal, and D. M. Bodine Hmgb3 deficiency deregulates proliferation and differentiation of common lymphoid and myeloid progenitors Blood, January 15, 2005; 105(2): 627 - 634. [Abstract] [Full Text] [PDF] M. Khandekar, N. Suzuki, J. Lewton, M. Yamamoto, and J. D. Engel Multiple, Distant Gata2 Enhancers Specify Temporally and Tissue-Specific Patterning in the Developing Urogenital System Mol. Cell. Biol., December 1, 2004; 24(23): 10263 - 10276. [Abstract] [Full Text] [PDF] K.-W. Ling, K. Ottersbach, J. P. van Hamburg, A. Oziemlak, F.-Y. Tsai, S. H. Orkin, R. Ploemacher, R. W. Hendriks, and E. Dzierzak GATA-2 Plays Two Functionally Distinct Roles during the Ontogeny of Hematopoietic Stem Cells J. Exp. Med., October 4, 2004; 200(7): 871 - 882. [Abstract] [Full Text] [PDF] R. Summer, D. N. Kotton, X. Sun, K. Fitzsimmons, and A. Fine Origin and phenotype of lung side population cells Am J Physiol Lung Cell Mol Physiol, September 1, 2004; 287(3): L477 - L483. [Abstract] [Full Text] [PDF] S. Monticelli, D. C. Solymar, and A. Rao Role of NFAT Proteins in IL13 Gene Transcription in Mast Cells J. Biol. Chem., August 27, 2004; 279(35): 36210 - 36218. [Abstract] [Full Text] [PDF] S. Pal, M. J. Nemeth, D. Bodine, J. L. Miller, J. Svaren, S. L. Thein, P. J. Lowry, and E. H. Bresnick Neurokinin-B Transcription in Erythroid Cells: DIRECT ACTIVATION BY THE HEMATOPOIETIC TRANSCRIPTION FACTOR GATA-1 J. Biol. Chem., July 23, 2004; 279(30): 31348 - 31356. [Abstract] [Full Text] [PDF] R. Lahlil, E. Lecuyer, S. Herblot, and T. Hoang SCL Assembles a Multifactorial Complex That Determines Glycophorin A Expression Mol. Cell. Biol., February 15, 2004; 24(4): 1439 - 1452. [Abstract] [Full Text] [PDF] S. Pal, A. B. Cantor, K. D. Johnson, T. B. Moran, M. E. Boyer, S. H. Orkin, and E. H. Bresnick Coregulator-dependent facilitation of chromatin occupancy by GATA-1 PNAS, January 27, 2004; 101(4): 980 - 985. [Abstract] [Full Text] [PDF] S. Gurbuxani, P. Vyas, and J. D. Crispino Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome Blood, January 15, 2004; 103(2): 399 - 406. [Abstract] [Full Text] [PDF] Y. Fujiwara, A. N. Chang, A. M. Williams, and S. H. Orkin Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development Blood, January 15, 2004; 103(2): 583 - 585. [Abstract] [Full Text] [PDF] S. G. Katz, A. Williams, J. Yang, Y. Fujiwara, A. P. Tsang, J. A. Epstein, and S. H. Orkin Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development PNAS, November 25, 2003; 100(24): 14030 - 14035. [Abstract] [Full Text] [PDF] M. E. Lasbury, X. Tang, P. J. Durant, and C.-H. Lee Effect of Transcription Factor GATA-2 on Phagocytic Activity of Alveolar Macrophages from Pneumocystis carinii-Infected Hosts Infect. Immun., September 1, 2003; 71(9): 4943 - 4952. [Abstract] [Full Text] [PDF] N. Minegishi, N. Suzuki, T. Yokomizo, X. Pan, T. Fujimoto, S. Takahashi, T. Hara, A. Miyajima, S.-i. Nishikawa, and M. Yamamoto Expression and domain-specific function of GATA-2 during differentiation of the hematopoietic precursor cells in midgestation mouse embryos Blood, August 1, 2003; 102(3): 896 - 905. [Abstract] [Full Text] [PDF] J. A. Grass, M. E. Boyer, S. Pal, J. Wu, M. J. Weiss, and E. H. Bresnick GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling PNAS, July 22, 2003; 100(15): 8811 - 8816. [Abstract] [Full Text] [PDF] Y. J. Suzuki, R. M. Day, C. C. Tan, T. H. Sandven, Q. Liang, J. D. Molkentin, and B. L. Fanburg Activation of GATA-4 by Serotonin in Pulmonary Artery Smooth Muscle Cells J. Biol. Chem., May 2, 2003; 278(19): 17525 - 17531. [Abstract] [Full Text] [PDF] M. E. Lasbury, P. J. Durant, M. S. Bartlett, J. W. Smith, and C.-H. Lee Correlation of Organism Burden and Alveolar Macrophage Counts during Infection with Pneumocystis carinii and Recovery Clin. Vaccine Immunol., March 1, 2003; 10(2): 293 - 302. [Abstract] [Full Text] [PDF] A. R. Migliaccio, R. A. Rana, M. Sanchez, R. Lorenzini, L. Centurione, L. Bianchi, A. M. Vannucchi, G. Migliaccio, and S. H. Orkin GATA-1 as a Regulator of Mast Cell Differentiation Revealed by the Phenotype of the GATA-1low Mouse Mutant J. Exp. Med., February 3, 2003; 197(3): 281 - 296. [Abstract] [Full Text] [PDF] Y. Kim, A.-G. Ma, K. Kitta, S. N. Fitch, T. Ikeda, Y. Ihara, A. R. Simon, T. Evans, and Y. J. Suzuki Anthracycline-Induced Suppression of GATA-4 Transcription Factor: Implication in the Regulation of Cardiac Myocyte Apoptosis Mol. Pharmacol., February 1, 2003; 63(2): 368 - 377. [Abstract] [Full Text] [PDF] B. Liu, Y. Sun, F. Jiang, S. Zhang, Y. Wu, Y. Lan, X. Yang, and N. Mao Disruption of Smad5 gene leads to enhanced proliferation of high-proliferative potential precursors during embryonic hematopoiesis Blood, January 1, 2003; 101(1): 124 - 133. [Abstract] [Full Text] [PDF] S. Ezoe, I. Matsumura, S. Nakata, K. Gale, K. Ishihara, N. Minegishi, T. Machii, T. Kitamura, M. Yamamoto, T. Enver, et al. GATA-2/estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21WAF1 and p27Kip1 proteins Blood, November 15, 2002; 100(10): 3512 - 3520. [Abstract] [Full Text] [PDF] Y.-L. Yu, Y.-J. Chiang, and J. J. Y. Yen GATA Factors Are Essential for Transcription of the Survival Gene E4bp4 and the Viability Response of Interleukin-3 in Ba/F3 Hematopoietic Cells J. Biol. Chem., July 19, 2002; 277(30): 27144 - 27153. [Abstract] [Full Text] [PDF] A. N. Chang, A. B. Cantor, Y. Fujiwara, M. B. Lodish, S. Droho, J. D. Crispino, and S. H. Orkin GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis PNAS, July 9, 2002; 99(14): 9237 - 9242. [Abstract] [Full Text] [PDF] A. B. Cantor, S. G. Katz, and S. H. Orkin Distinct Domains of the GATA-1 Cofactor FOG-1 Differentially Influence Erythroid versus Megakaryocytic Maturation Mol. Cell. Biol., June 15, 2002; 22(12): 4268 - 4279. [Abstract] [Full Text] [PDF] K. McNagny and T. Graf Making Eosinophils Through Subtle Shifts in Transcription Factor Expression J. Exp. Med., June 3, 2002; 195(11): F43 - F47. [Full Text] [PDF] S. Ghatpande, A. Ghatpande, J. Sher, M. H. Zile, and T. Evans Retinoid signaling regulates primitive (yolk sac) hematopoiesis Blood, April 1, 2002; 99(7): 2379 - 2386. [Abstract] [Full Text] [PDF] S. J. Morrison, D. Qian, L. Jerabek, B. A. Thiel, I.-K. Park, P. S. Ford, M. J. Kiel, N. J. Schork, I. L. Weissman, and M. F. Clarke A Genetic Determinant That Specifically Regulates the Frequency of Hematopoietic Stem Cells J. Immunol., January 15, 2002; 168(2): 635 - 642. [Abstract] [Full Text] [PDF] Y. Ozawa, M. Towatari, S. Tsuzuki, F. Hayakawa, T. Maeda, Y. Miyata, M. Tanimoto, and H. Saito Histone deacetylase 3 associates with and represses the transcription factor GATA-2 Blood, October 1, 2001; 98(7): 2116 - 2123. [Abstract] [Full Text] [PDF] A. M. Vannucchi, L. Bianchi, C. Cellai, F. Paoletti, V. Carrai, A. Calzolari, L. Centurione, R. Lorenzini, C. Carta, E. Alfani, et al. Accentuated response to phenylhydrazine and erythropoietin in mice genetically impaired for their GATA-1 expression (GATA-1low mice) Blood, May 15, 2001; 97(10): 3040 - 3050. [Abstract] [Full Text] [PDF] B. D. Car and V. M. Eng Special Considerations in the Evaluation of the Hematology and Hemostasis of Mutant Mice Vet. Pathol., January 1, 2001; 38(1): 20 - 30. [Abstract] [Full Text] [PDF] E. E. Morrisey GATA-6: The Proliferation Stops Here : Cell Proliferation in Glomerular Mesangial and Vascular Smooth Muscle Cells Circ. Res., October 13, 2000; 87(8): 638 - 640. [Full Text] [PDF] T.-X. Liu, J.-W. Zhang, J. Tao, R.-B. Zhang, Q.-H. Zhang, C.-J. Zhao, J.-H. Tong, M. Lanotte, S. Waxman, S.-J. Chen, et al. Gene expression networks underlying retinoic acid-induced differentiation of acute promyelocytic leukemia cells Blood, August 15, 2000; 96(4): 1496 - 1504. [Abstract] [Full Text] [PDF] A. E. Deconinck, P. E. Mead, S. G. Tevosian, J. D. Crispino, S. G. Katz, L. I. Zon, and S. H. Orkin FOG acts as a repressor of red blood cell development in Xenopus Development, May 15, 2000; 127(10): 2031 - 2040. [Abstract] [PDF] T. Lebestky, T. Chang, V. Hartenstein, and U. Banerjee Specification of Drosophila Hematopoietic Lineage by Conserved Transcription Factors Science, April 7, 2000; 288(5463): 146 - 149. [Abstract] [Full Text] S. Delassus, I. Titley, and T. Enver Functional and Molecular Analysis of Hematopoietic Progenitors Derived From the Aorta-Gonad-Mesonephros Region of the Mouse Embryo Blood, September 1, 1999; 94(5): 1495 - 1503. [Abstract] [Full Text] [PDF] M. Holmes, J. Turner, A. Fox, O. Chisholm, M. Crossley, and B. Chong hFOG-2, a Novel Zinc Finger Protein, Binds the Co-repressor mCtBP2 and Modulates GATA-mediated Activation J. Biol. Chem., August 13, 1999; 274(33): 23491 - 23498. [Abstract] [Full Text] [PDF] C. Heyworth, K. Gale, M. Dexter, G. May, and T. Enver A GATA-2/estrogen receptor chimera functions as a ligand-dependent negative regulator of self-renewal Genes & Dev., July 15, 1999; 13(14): 1847 - 1860. [Abstract] [Full Text] D. A. Persons, J. A. Allay, E. R. Allay, R. A. Ashmun, D. Orlic, S. M. Jane, J. M. Cunningham, and A. W. Nienhuis Enforced Expression of the GATA-2 Transcription Factor Blocks Normal Hematopoiesis Blood, January 15, 1999; 93(2): 488 - 499. [Abstract] [Full Text] [PDF] M.-C. Labastie, F. Cortes, P.-H. Romeo, C. Dulac, and B. Peault Molecular Identity of Hematopoietic Precursor Cells Emerging in the Human Embryo Blood, November 15, 1998; 92(10): 3624 - 3635. [Abstract] [Full Text] [PDF] Z. Wang and S. Melmed Functional Map of a Placenta-specific Enhancer of the Human Leukemia Inhibitory Factor Receptor Gene J. Biol. Chem., October 2, 1998; 273(40): 26069 - 26077. [Abstract] [Full Text] [PDF] R. L. Orford, C. Robinson, J. M. Haydon, R. K. Patient, and M. J. Guille The Maternal CCAAT Box Transcription Factor Which Controls GATA-2 Expression Is Novel and Developmentally Regulated and Contains a Double-Stranded-RNA-Binding Subunit Mol. Cell. Biol., September 1, 1998; 18(9): 5557 - 5566. [Abstract] [Full Text] A. P. Tsang, Y. Fujiwara, D. B. Hom, and S. H. Orkin Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG Genes & Dev., April 15, 1998; 12(8): 1176 - 1188. [Abstract] [Full Text] P. Mead, C. Kelley, P. Hahn, O Piedad, and L. Zon SCL specifies hematopoietic mesoderm in Xenopus embryos Development, January 7, 1998; 125(14): 2611 - 2620. [Abstract] [PDF] C. Lancrin, E. Schneider, F. Lambolez, M.-L. Arcangeli, C. Garcia-Cordier, B. Rocha, and S. Ezine Major T Cell Progenitor Activity in Bone Marrow-derived Spleen Colonies J. Exp. Med., April 1, 2002; 195(7): 919 - 929. [Abstract] [Full Text] [PDF]

	Copyright © 1997 by American Society of Hematology         Online ISSN: 1528-0020