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Cellular expression of antiapoptotic BCL-2 oncoprotein in newly diagnosed
childhood acute lymphoblastic leukemia: a Children's Cancer Group Study
FM Uckun, Z Yang, H Sather, P Steinherz, J Nachman, B Bostrom, L Crotty, M Sarquis, O Ek, T Zeren, D Tubergen, G Reaman and P Gaynon
Biotherapy Institute, University of Minnesota, Roseville 55113, USA.
We found a marked variation in BCL-2 oncoprotein expression levels of
primary leukemic cells from 338 children with newly diagnosed acute
lymphoblastic leukemia (ALL). None of the high-risk features predictive of
poor treatment outcome in childhood ALL, such as older age, high white
blood cell (WBC) count, organomegaly, T-lineage immunophenotype, ability of
leukemic cells to cause overt leukemia in severe combined immunodeficient
(SCID) mice, presence of MLL-AF4, and BCR-ABL fusion transcripts were
associated with high levels of BCL-2 expression. Overall, high BCL-2 levels
were not associated with slow early response, failure to achieve complete
remission, or poor event-free survival. High BCL-2 levels in primary
leukemic cells predicted slow early response only in T-lineage ALL
patients, which comprised approximately 15% of the total patient
population. Even for this small subset of patients, the level of BCL-2
expression did not have a significant impact on the short-term event-free
survival.
Volume 89,
Issue 10,
pp. 3769-3777,
05/15/1997
Copyright © 1997 by The American Society of Hematology
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