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Primitive human hematopoietic cells are enriched in cord blood compared
with adult bone marrow or mobilized peripheral blood as measured by the
quantitative in vivo SCID-repopulating cell assay
JC Wang, M Doedens and JE Dick
Department of Genetics, Research Institute, Hospital for Sick Children,
University of Toronto, Canada.
We have previously reported the development of in vivo functional assays
for primitive human hematopoietic cells based on their ability to
repopulate the bone marrow (BM) of severe combined immunodeficient (SCID)
and nonobese diabetic/SCID (NOD/SCID) mice following intravenous
transplantation. Accumulated data from gene marking and cell purification
experiments indicate that the engrafting cells (defined as
SCID-repopulating cells or SRC) are biologically distinct from and more
primitive than most cells that can be assayed in vitro. Here we demonstrate
through limiting dilution analysis that the NOD/SCID xenotransplant model
provides a quantitative assay for SRC. Using this assay, the frequency of
SRC in cord blood (CB) was found to be 1 in 9.3 x 10(5) cells. This was
significantly higher than the frequency of 1 SRC in 3.0 x 10(6) adult BM
cells or 1 in 6.0 x 10(6) mobilized peripheral blood (PB) cells from normal
donors. Mice transplanted with limiting numbers of SRC were engrafted with
both lymphoid and multilineage myeloid human cells. This functional assay
is currently the only available method for quantitative analysis of human
hematopoietic cells with repopulating capacity. Both CB and mobilized PB
are increasingly being used as alternative sources of hematopoietic stem
cells in allogeneic transplantation. Thus, the findings reported here will
have important clinical as well as biologic implications.
Volume 89,
Issue 11,
pp. 3919-3924,
06/01/1997
Copyright © 1997 by The American Society of Hematology
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D. Dunon, N. Allioli, O. Vainio, C. Ody, and B.A. Imhof
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J. D. Cashman and C. J. Eaves
Human Growth Factor-Enhanced Regeneration of Transplantable Human Hematopoietic Stem Cells in Nonobese Diabetic/Severe Combined Immunodeficient Mice
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J. C.M. van der Loo, H. Hanenberg, R. J. Cooper, F.-Y. Luo, E. N. Lazaridis, and D. A. Williams
Nonobese Diabetic/Severe Combined Immunodeficiency (NOD/SCID) Mouse as a Model System to Study the Engraftment and Mobilization of Human Peripheral Blood Stem Cells
Blood,
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[Abstract]
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J.F. Tisdale, Y. Hanazono, S.E. Sellers, B.A. Agricola, M.E. Metzger, R.E. Donahue, and C.E. Dunbar
Ex Vivo Expansion of Genetically Marked Rhesus Peripheral Blood Progenitor Cells Results in Diminished Long-Term Repopulating Ability
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F. Dazzi, D. Capelli, R. Hasserjian, F. Cotter, M. Corbo, A. Poletti, W. Chinswangwatanakul, J. M. Goldman, and M. Y. Gordon
The Kinetics and Extent of Engraftment of Chronic Myelogenous Leukemia Cells in Non-Obese Diabetic/Severe Combined Immunodeficiency Mice Reflect the Phase of the Donor's Disease: An In Vivo Model of Chronic Myelogenous Leukemia Biology
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D. Orlic, L. J. Girard, S. M. Anderson, L. C. Pyle, M. C. Yoder, H. E. Broxmeyer, and D. M. Bodine
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[Abstract]
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J. L. Abkowitz, M. Taboada, G. H. Shelton, S. N. Catlin, P. Guttorp, and J. V. Kiklevich
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M. M.A. Verstegen, P. B. van Hennik, W. Terpstra, C. van den Bos, J. J. Wielenga, N. van Rooijen, R. E. Ploemacher, G. Wagemaker, and A. W. Wognum
Transplantation of Human Umbilical Cord Blood Cells in Macrophage-Depleted SCID Mice: Evidence for Accessory Cell Involvement in Expansion of Immature CD34+CD38- Cells
Blood,
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[Abstract]
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M. A. Dao, A. J. Shah, G. M. Crooks, and J. A. Nolta
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M. Bhatia, D. Bonnet, U. Kapp, J. C.Y. Wang, B. Murdoch, and J. E. Dick
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