|
|
 Previous Article | Table of Contents | Next Article 
The t(11;16)(q23;p13) translocation in myelodysplastic syndrome fuses the
MLL gene to the CBP gene
T Taki, M Sako, M Tsuchida and Y Hayashi
Department of Pediatrics, Faculty of Medicine, University of Tokyo,
Bunkyo-ku, Japan.
The recurrent translocation t(11;16)(q23;p13) has been reported to be
associated with therapy-related acute leukemia. The MLL gene involved in
other 11q23 abnormalities was also rearranged by this translocation. We
analyzed two patients with myelodysplastic syndrome with t(11;16) and
showed that the MLL gene on 11q23 was fused with CREB-binding protein (CBP)
gene on 16p13 in these patients. The CBP gene encodes a transcriptional
adaptor/coactivator protein and it is mutated in patients with
Rubinstein-Taybi syndrome. The CBP gene is also involved in acute myeloid
leukemia (AML) with t(8;16)(p11;p13). In-frame MLL-CBP fusion transcripts
combine the MLL AT-hook motifs and DNA methyltransferase homology region
with a largely intact CBP. Our results combined with the finding of the
MOZ-CBP fusion in t(8;16)-AML suggest that the CBP gene may be associated
with leukemogenesis through translocations.
Volume 89,
Issue 11,
pp. 3945-3950,
06/01/1997
Copyright © 1997 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
O. M. Odenike, S. Alkan, D. Sher, J. E. Godwin, D. Huo, S. J. Brandt, M. Green, J. Xie, Y. Zhang, D. H. Vesole, et al.
Histone Deacetylase Inhibitor Romidepsin Has Differential Activity in Core Binding Factor Acute Myeloid Leukemia
Clin. Cancer Res.,
November 1, 2008;
14(21):
7095 - 7101.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Strehl, K. Nebral, M. Konig, J. Harbott, H. Strobl, R. Ratei, S. Struski, B. Bielorai, M. Lessard, M. Zimmermann, et al.
ETV6-NCOA2: A Novel Fusion Gene in Acute Leukemia Associated with Coexpression of T-Lymphoid and Myeloid Markers and Frequent NOTCH1 Mutations
Clin. Cancer Res.,
February 15, 2008;
14(4):
977 - 983.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. A. Nguyen, P. P. Pandolfi, Y. Aikawa, Y. Tagata, M. Ohki, and I. Kitabayashi
Physical and functional link of the leukemia-associated factors AML1 and PML
Blood,
January 1, 2005;
105(1):
292 - 300.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-J. Yang
The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases
Nucleic Acids Res.,
February 11, 2004;
32(3):
959 - 976.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. B. Glassman and K. J. Hayes
Translocation (11;16)(q23;p13) Acute Myelogenous Leukemia and Myelodysplastic Syndrome
Ann. Clin. Lab. Sci.,
July 1, 2003;
33(3):
285 - 288.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Hirai
Molecular Mechanisms of Myelodysplastic Syndrome
Jpn. J. Clin. Oncol.,
April 1, 2003;
33(4):
153 - 160.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. W. So and M. L. Cleary
MLL-AFX Requires the Transcriptional Effector Domains of AFX To Transform Myeloid Progenitors and Transdominantly Interfere with Forkhead Protein Function
Mol. Cell. Biol.,
September 15, 2002;
22(18):
6542 - 6552.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Ono, T. Taki, T. Taketani, M. Taniwaki, H. Kobayashi, and Y. Hayashi
LCX, Leukemia-associated Protein with a CXXC Domain, Is Fused to MLL in Acute Myeloid Leukemia with Trilineage Dysplasia Having t(10;11)(q22;q23)
Cancer Res.,
July 15, 2002;
62(14):
4075 - 4080.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. B. Dash, I. R. Williams, J. L. Kutok, M. H. Tomasson, E. Anastasiadou, K. Lindahl, S. Li, R. A. Van Etten, J. Borrow, D. Housman, et al.
A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9
PNAS,
May 28, 2002;
99(11):
7622 - 7627.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. F. DiMartino, P. M. Ayton, E. H. Chen, C. C. Naftzger, B. D. Young, and M. L. Cleary
The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10
Blood,
May 15, 2002;
99(10):
3780 - 3785.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. A. Blobel
CBP and p300: versatile coregulators with important roles in hematopoietic gene expression
J. Leukoc. Biol.,
April 1, 2002;
71(4):
545 - 556.
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Murata, R. Kurokawa, A. Krones, K. Tatsumi, M. Ishii, T. Taki, M. Masuno, H. Ohashi, M. Yanagisawa, M. G. Rosenfeld, et al.
Defect of histone acetyltransferase activity of the nuclear transcriptional coactivator CBP in Rubinstein-Taybi syndrome
Hum. Mol. Genet.,
May 1, 2001;
10(10):
1071 - 1076.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Ernst, J. Wang, M. Huang, R. H. Goodman, and S. J. Korsmeyer
MLL and CREB Bind Cooperatively to the Nuclear Coactivator CREB-Binding Protein
Mol. Cell. Biol.,
April 1, 2001;
21(7):
2249 - 2258.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
I. Panagopoulos, T. Fioretos, M. Isaksson, U. Samuelsson, R. Billstrom, B. Strombeck, F. Mitelman, and B. Johansson
Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13)
Hum. Mol. Genet.,
February 1, 2001;
10(4):
395 - 404.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. E. Sterner and S. L. Berger
Acetylation of Histones and Transcription-Related Factors
Microbiol. Mol. Biol. Rev.,
June 1, 2000;
64(2):
435 - 459.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. M. Pao, R. Janknecht, H. Ruffner, T. Hunter, and I. M. Verma
CBP/p300 interact with and function as transcriptional coactivators of BRCA1
PNAS,
February 1, 2000;
97(3):
1020 - 1025.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Hayashi, Y. Honma, N. Niitsu, T. Taki, F. Bessho, M. Sako, T. Mori, M. Yanagisawa, K. Tsuji, and T. Nakahata
SN-1, A Novel Leukemic Cell Line with t(11;16)(q23;p13): Myeloid Characteristics and Resistance to Retinoids and Vitamin D3
Cancer Res.,
February 1, 2000;
60(4):
1139 - 1145.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
G. A. Blobel
CREB-binding protein and p300: molecular integrators of hematopoietic transcription
Blood,
February 1, 2000;
95(3):
745 - 755.
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Taki, H. Kano, M. Taniwaki, M. Sako, M. Yanagisawa, and Y. Hayashi
AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)
PNAS,
December 7, 1999;
96(25):
14535 - 14540.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. T. Adler, R. Chinery, D. Y. Wu, S. J. Kussick, J. M. Payne, A. J. Fornace Jr., and D. C. Tkachuk
Leukemic HRX Fusion Proteins Inhibit GADD34-Induced Apoptosis and Associate with the GADD34 and hSNF5/INI1 Proteins
Mol. Cell. Biol.,
October 1, 1999;
19(10):
7050 - 7060.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Champagne, N. R. Bertos, N. Pelletier, A. H. Wang, M. Vezmar, Y. Yang, H. H. Heng, and X.-J. Yang
Identification of a Human Histone Acetyltransferase Related to Monocytic Leukemia Zinc Finger Protein
J. Biol. Chem.,
October 1, 1999;
274(40):
28528 - 28536.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Taki, H. Ohnishi, K. Shinohara, M. Sako, F. Bessho, M. Yanagisawa, and Y. Hayashi
AF17q25, a Putative Septin Family Gene, Fuses the MLL Gene in Acute Myeloid Leukemia with t(11;17)(q23;q25)
Cancer Res.,
September 1, 1999;
59(17):
4261 - 4265.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. L. Redner, J. Wang, and J. M. Liu
Chromatin Remodeling and Leukemia: New Therapeutic Paradigms
Blood,
July 15, 1999;
94(2):
417 - 428.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Felix and B. J. Lange
Leukemia in Infants
Oncologist,
June 1, 1999;
4(3):
225 - 240.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. Osaka, J. D. Rowley, and N. J. Zeleznik-Le
MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)
PNAS,
May 25, 1999;
96(11):
6428 - 6433.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Maki, K. Mitani, T. Yamagata, M. Kurokawa, Y. Kanda, Y. Yazaki, and H. Hirai
Transcriptional Inhibition of p53 by the MLL/MEN Chimeric Protein Found in Myeloid Leukemia
Blood,
May 15, 1999;
93(10):
3216 - 3224.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. H. Kasper, P. K. Brindle, C. A. Schnabel, C. E. J. Pritchard, M. L. Cleary, and J. M. A. van Deursen
CREB Binding Protein Interacts with Nucleoporin-Specific FG Repeats That Activate Transcription and Mediate NUP98-HOXA9 Oncogenicity
Mol. Cell. Biol.,
January 1, 1999;
19(1):
764 - 776.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Taki, N. Shibuya, M. Taniwaki, R. Hanada, K. Morishita, F. Bessho, M. Yanagisawa, and Y. Hayashi
ABI-1, a Human Homolog to Mouse Abl-Interactor 1, Fuses the MLL Gene in Acute Myeloid Leukemia With t(10;11)(p11.2;q23)
Blood,
August 15, 1998;
92(4):
1125 - 1130.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. D. Megonigal, E. F. Rappaport, D. H. Jones, T. M. Williams, B. D. Lovett, K. M. Kelly, P. H. Lerou, T. Moulton, M. L. Budarf, and C. A. Felix
t(11;22)(q23;q11.2) in acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes
PNAS,
May 26, 1998;
95(11):
6413 - 6418.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Carapeti, R. C.T. Aguiar, J. M. Goldman, and N. C.P. Cross
A Novel Fusion Between MOZ and the Nuclear Receptor Coactivator TIF2 in Acute Myeloid Leukemia
Blood,
May 1, 1998;
91(9):
3127 - 3133.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Guidez, S. Ivins, J. Zhu, M. Soderstrom, S. Waxman, and A. Zelent
Reduced Retinoic Acid-Sensitivities of Nuclear Receptor Corepressor Binding to PML- and PLZF-RARalpha Underlie Molecular Pathogenesis and Treatment of Acute Promyelocytic Leukemia
Blood,
April 15, 1998;
91(8):
2634 - 2642.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. K. Slany, C. Lavau, and M. L. Cleary
The Oncogenic Capacity of HRX-ENL Requires the Transcriptional Transactivation Activity of ENL and the DNA Binding Motifs of HRX
Mol. Cell. Biol.,
January 1, 1998;
18(1):
122 - 129.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R.J. LIN, H.-Y. KAO, P. ORDENTLICH, and R.M. EVANS
The Transcriptional Basis of Steroid Physiology
Cold Spring Harb Symp Quant Biol,
January 1, 1998;
63(0):
577 - 586.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. Dowell, J. E. Ishmael, D. Avram, V. J. Peterson, D. J. Nevrivy, and M. Leid
p300 Functions as a Coactivator for the Peroxisome Proliferator-activated Receptor alpha
J. Biol. Chem.,
December 26, 1997;
272(52):
33435 - 33443.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Ida, I. Kitabayashi, T. Taki, M. Taniwaki, K. Noro, M. Yamamoto, M. Ohki, and Y. Hayashi
Adenoviral E1A-Associated Protein p300 Is Involved in Acute Myeloid Leukemia With t(11; 22)(q23; q13)
Blood,
December 15, 1997;
90(12):
4699 - 4704.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H. Kersey
Fifty Years of Studies of the Biology and Therapy of Childhood Leukemia
Blood,
December 1, 1997;
90(11):
4243 - 4251.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. T. Adler, F. S. Nallaseth, G. Walter, and D. C. Tkachuk
HRX Leukemic Fusion Proteins Form a Heterocomplex with the Leukemia-associated Protein SET and Protein Phosphatase 2A
J. Biol. Chem.,
November 7, 1997;
272(45):
28407 - 28414.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. M. Sobulo, J. Borrow, R. Tomek, S. Reshmi, A. Harden, B. Schlegelberger, D. Housman, N. A. Doggett, J. D. Rowley, and N. J. Zeleznik-Le
MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)
PNAS,
August 5, 1997;
94(16):
8732 - 8737.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. J. Kourlas, M. P. Strout, B. Becknell, M. L. Veronese, C. M. Croce, K. S. Theil, R. Krahe, T. Ruutu, S. Knuutila, C. D. Bloomfield, et al.
Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: Evidence for its fusion with MLL in acute myeloid leukemia
PNAS,
February 29, 2000;
97(5):
2145 - 2150.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
