|
|
 Previous Article | Table of Contents | Next Article 
Activation of human T cells by major histocompatability complex class II
expressing neutrophils: proliferation in the presence of superantigen, but
not tetanus toxoid
NA Fanger, C Liu, PM Guyre, K Wardwell, J O'Neil, TL Guo, TP Christian, SP Mudzinski and EJ Gosselin
Department of Physiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH,
USA.
The primary function of polymorphonuclear neutrophils (PMN) in the immune
response appears to be acute phagocytic clearance of foreign pathogens and
release of inflammatory mediators. Consistent with their assumed lack of
major histocompatibility complex (MHC) class II expression, PMN have not
been considered to play a role in antigen presentation and T-cell
activation. However, recent reports have shown that human PMN can express
MHC class II molecules both in vitro and in vivo after stimulation with
either granulocyte-macrophage colony- stimulating factor (GM-CSF) or
interferon-gamma (IFN-gamma). Thus, under appropriate conditions, PMN could
play a significant role in immune regulation, including T-cell activation.
In this report, we demonstrate that human class II-expressing PMN can serve
as accessory cells in superantigen (SAg)-mediated T-cell activation. This
accessory activity for SAg presentation was present only after induction of
MHC class II expression, and was especially pronounced following culture of
PMN with GM-CSF plus IFN-gamma, which acted synergistically to induce MHC
class II molecules on PMN. Moreover, the level of MHC class II expression
and the magnitude of SAg-induced T-cell responses were found to be highly
correlated and distinctly donor dependent, with PMN from some donors
repeatedly showing fivefold higher responses than PMN from other donors. On
the other hand, culture of PMN with GM-CSF plus IFN- gamma under conditions
that resulted in optimal MHC class II expression did not enable them to
function as antigen-presenting cells for either intact tetanus toxoid (TT)
or for a TT peptide. These results delineate a new pathway for T-cell
activation by SAg that may play an important role in the severity of
SAg-induced inflammatory responses. They also identify a donor-specific
polymorphism for induction of PMN MHC class II expression which may be of
significance for therapies involving GM- CSF and IFN-gamma.
Volume 89,
Issue 11,
pp. 4128-4135,
06/01/1997
Copyright © 1997 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
C. Iking-Konert, T. Vogl, B. Prior, C. Wagner, O. Sander, E. Bleck, B. Ostendorf, M. Schneider, K. Andrassy, and G. M. Hansch
T lymphocytes in patients with primary vasculitis: expansion of CD8+ T cells with the propensity to activate polymorphonuclear neutrophils
Rheumatology,
May 1, 2008;
47(5):
609 - 616.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. C. Kousis, B. W. Henderson, P. G. Maier, and S. O. Gollnick
Photodynamic Therapy Enhancement of Antitumor Immunity Is Regulated by Neutrophils
Cancer Res.,
November 1, 2007;
67(21):
10501 - 10510.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K.-J. Li, M.-C. Lu, S.-C. Hsieh, C.-H. Wu, H.-S. Yu, C.-Y. Tsai, and C.-L. Yu
Release of surface-expressed lactoferrin from polymorphonuclear neutrophils after contact with CD4+T cells and its modulation on Th1/Th2 cytokine production
J. Leukoc. Biol.,
August 1, 2006;
80(2):
350 - 358.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. A. Whale, T. K. Beskorwayne, L. A. Babiuk, and P. J. Griebel
Bovine polymorphonuclear cells passively acquire membrane lipids and integral membrane proteins from apoptotic and necrotic cells
J. Leukoc. Biol.,
June 1, 2006;
79(6):
1226 - 1233.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. D. Kobayashi, J. M. Voyich, A. R. Whitney, and F. R. DeLeo
Spontaneous neutrophil apoptosis and regulation of cell survival by granulocyte macrophage-colony stimulating factor
J. Leukoc. Biol.,
December 1, 2005;
78(6):
1408 - 1418.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C Iking-Konert, B Ostendorf, O Sander, M Jost, C Wagner, L Joosten, M Schneider, and G M Hansch
Transdifferentiation of polymorphonuclear neutrophils to dendritic-like cells at the site of inflammation in rheumatoid arthritis: evidence for activation by T cells
Ann Rheum Dis,
October 1, 2005;
64(10):
1436 - 1442.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. G. Mordue and L. D. Sibley
A novel population of Gr-1+-activated macrophages induced during acute toxoplasmosis
J. Leukoc. Biol.,
December 1, 2003;
74(6):
1015 - 1025.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. J. Botelho, H. Tapper, W. Furuya, D. Mojdami, and S. Grinstein
Fc{gamma}R-Mediated Phagocytosis Stimulates Localized Pinocytosis in Human Neutrophils
J. Immunol.,
October 15, 2002;
169(8):
4423 - 4429.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Fulton, S. M. Reba, T. D. Martin, and W. H. Boom
Neutrophil-Mediated Mycobacteriocidal Immunity in the Lung during Mycobacterium bovis BCG Infection in C57BL/6 Mice
Infect. Immun.,
September 1, 2002;
70(9):
5322 - 5327.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. S. Potter and C. V. Harding
Neutrophils Process Exogenous Bacteria Via an Alternate Class I MHC Processing Pathway for Presentation of Peptides to T Lymphocytes
J. Immunol.,
September 1, 2001;
167(5):
2538 - 2546.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. K. Bliss, L. C. Gavrilescu, A. Alcaraz, and E. Y. Denkers
Neutrophil Depletion during Toxoplasma gondii Infection Leads to Impaired Immunity and Lethal Systemic Pathology
Infect. Immun.,
August 1, 2001;
69(8):
4898 - 4905.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Lei, J. Altstaedt, M. von der Ohe, T. Proft, U. Gross, and L. Rink
Induction of interleukin-8 in human neutrophils after MHC class II cross-linking with superantigens
J. Leukoc. Biol.,
July 1, 2001;
70(1):
80 - 86.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Yamashiro, H. Kamohara, J.-M. Wang, D. Yang, W.-H. Gong, and T. Yoshimura
Phenotypic and functional change of cytokine-activated neutrophils: inflammatory neutrophils are heterogeneous and enhance adaptive immune responses
J. Leukoc. Biol.,
May 1, 2001;
69(5):
698 - 704.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. Yamashiro, J.-M. Wang, D. Yang, W.-H. Gong, H. Kamohara, and T. Yoshimura
Expression of CCR6 and CD83 by cytokine-activated human neutrophils
Blood,
December 1, 2000;
96(12):
3958 - 3963.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Tacchini-Cottier, C. Zweifel, Y. Belkaid, C. Mukankundiye, M. Vasei, P. Launois, G. Milon, and J. A. Louis
An Immunomodulatory Function for Neutrophils During the Induction of a CD4+ Th2 Response in BALB/c Mice Infected with Leishmania major
J. Immunol.,
September 1, 2000;
165(5):
2628 - 2636.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. M. Halder, M. Bluggel, S. Heinzel, G. Pawelec, H. E. Meyer, and H. Kalbacher
Defensins are dominant HLA-DR-associated self-peptides from CD34- peripheral blood mononuclear cells of different tumor patients (plasmacytoma, chronic myeloid leukemia)
Blood,
May 1, 2000;
95(9):
2890 - 2896.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Oehler, O. Majdic, W. F. Pickl, J. Stockl, E. Riedl, J. Drach, K. Rappersberger, K. Geissler, and W. Knapp
Neutrophil Granulocyte-committed Cells Can Be Driven to Acquire Dendritic Cell Characteristics
J. Exp. Med.,
April 6, 1998;
187(7):
1019 - 1028.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
