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Differential susceptibility to HIV-GP120-sensitized apoptosis in CD4+ T-
cell clones with different T-helper phenotypes: role of CD95/CD95L
interactions
P Accornero, M Radrizzani, D Delia, F Gerosa, R Kurrle and MP Colombo
Division of Experimental Oncology D, Istituto Nazionale Tumori, Milan,
Italy.
The susceptibility of Th1 and Th2 cell clones to apoptosis following
HIV-gp120/CD4 cross-linking and TCR activation was investigated. We show
that only Th1 clones are susceptible to HIV-gp120-sensitized apoptosis,
although both types of clones express similar levels of CD4 and bind
similar amounts of recombinant gp120. Both types of clones, however,
undergo apoptosis induced by CD95 cross-linking with agonistic monoclonal
antibody (MoAb). Apoptosis induced by gp120 in the Th1 clones is inhibited
by either an anti-CD95 neutralizing MoAb or an anti- CD95L neutralizing
MoAb as well as by a specific interleukin-1 beta converting enzyme (ICE)
inhibitor. When triggered to apoptosis by gp120, Th1 but not Th2 clones
express both cell-associated and soluble CD95L. The CD95L produced by Th1
clones induces cell death, inhibitable by anti-CD95 neutralizing MoAb, of
CD95 positive Jurkat cells. These data suggest that, like
activation-induced apoptosis, HIV-gp120 sensitized apoptosis in Th1 clones
occurs via CD95/CD95L interaction and that lack or insufficient production
of CD95L is responsible, at least in part, for the resistance of Th2 clones
to such apoptosis.
Volume 89,
Issue 2,
pp. 558-569,
01/15/1997
Copyright © 1997 by The American Society of Hematology
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