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Frequent jumping translocations of chromosomal segments involving the ABL
oncogene alone or in combination with CD3-MLL genes in secondary leukemias
K Tanaka, M Arif, M Eguchi, T Kyo, H Dohy and N Kamada
Department of Cancer Cytogenetics, Hiroshima University, Japan.
Seven secondary leukemia patients were treated for solid tumors or
malignant lymphoma with anticancer drugs or radiation. We studied bone
marrow samples from these patients by fluorescence in situ hybridization
(FISH). Of the seven patients, three had increased signals for the ABL
oncogene (9q34) on interphase nuclei and at metaphase. One of the three
patients also had four signals for the CD3 (MLL) region (11q23). Whole
painting probes revealed that these chromosomal regions were translocated
onto structurally abnormal chromosomes, resulting in partial tri-, tetra-
or penta-somy of these regions. We called this type of translocation
"segmental jumping translocation (SJT)." SJT of the ABL oncogene was not
detected in samples from 15 patients with de novo acute myelocytic leukemia
(AML), 12 with myelodysplastic syndrome (MDS), or 20 with chronic
myelocytic leukemia (CML) at the chronic phase. Furthermore, monosomy 7 was
also found in the patients with the gene amplification. These results
indicate that SJT of ABL and/or CD3 (MLL) genes is associated with the
leukemogenesis of secondary leukemia. The SJT may be one mechanism of gene
amplification.
Volume 89,
Issue 2,
pp. 596-600,
01/15/1997
Copyright © 1997 by The American Society of Hematology
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