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Role of bcl-2 in the development of lymphoid cells from the hematopoietic
stem cell
Y Matsuzaki, K Nakayama, K Nakayama, T Tomita, M Isoda, DY Loh and H Nakauchi
Department of Immunology, University of Tsukuba, Ibaraki, Japan.
To investigate the role of bcl-2 in lymphohematopoiesis, a long-term bone
marrow reconstitution system was established. Transplantation of 1,000
c-Kit+ Sca-1+ and lineage markers negative cells from bcl-2-l- mouse bone
marrow resulted in long-term reconstitution of nonlymphoid cells. However,
T cells were totally absent and B-lymphocyte development was severely
impaired at a very early stage of differentiation in the chimeric mouse. On
the other hand, transplantation of day 14 fetal liver cells from
bcl-2-l-mice resulted in generation of both T and B cells in the recipient,
albeit transiently. These data suggest that bcl-2 plays a critical role in
the development of lymphoid progenitor cells from the hematopoietic stem
cell (HSC), but is not essential for the development of nonlymphoid cells
and the self-renewal of HSC. In addition, lymphopoiesis from fetal liver
HSC appears to be less dependent on bcl-2 than adult bone marrow HSC.
Volume 89,
Issue 3,
pp. 853-862,
02/01/1997
Copyright © 1997 by The American Society of Hematology
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