|
|
 Previous Article | Table of Contents | Next Article 
A new subtype of large B-cell lymphoma expressing the ALK kinase and
lacking the 2; 5 translocation
G Delsol, L Lamant, B Mariame, K Pulford, N Dastugue, P Brousset, F Rigal- Huguet, T al Saati, DP Cerretti, SW Morris and DY Mason
Department of Pathology, CHU Purpan, Toulouse, France.
Seven cases of large B-cell lymphoma which define a previously unrecognized
subgroup are reported. Morphologically they are comprised of monomorphic
large immunoblast-like cells, containing large central nucleoli, which tend
to invade lymphatic sinuses. Superficially they resemble anaplastic large
cell lymphoma (ALCL) but they lack CD30. These lymphomas express epithelial
membrane antigen (as do ALCL), but also contain intracytoplasmic IgA of a
single light chain type (five cases) and an endoplasmic
reticulum-associated marker detected by antibody VS38. They lack
lineage-associated leukocyte antigens with the exception of CD4 (5 of 5
cases) and CD57 (5 of 7 cases). They are labeled by antibodies detecting
both the intracytoplasmic and extracellular regions of the ALK receptor
kinase, suggesting that they express the full-length form of this molecule.
This was confirmed by Western blotting (in the one case tested) which
showed a band of 200 kD in tumor cell lysates, and by polymerase chain
reaction (PCR) amplification of mRNA encoding intracellular and
extracellular ALK sequences (in the two cases tested). There was no
evidence by cytogenetics (one case analyzed) or reverse transcriptase-PCR
(three cases tested) of the 2; 5 translocation or the resultant NPM-ALK
gene, as is commonly found in ALCL. All but one of the patients were male
and all but one were adults, and in all but the latter case the disease
followed an aggressive course.
Volume 89,
Issue 5,
pp. 1483-1490,
03/01/1997
Copyright © 1997 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J. K. C. Chan, L. Lamant, E. Algar, G. Delsol, W. Y. W. Tsang, K. C. Lee, K. Tiedemann, and C. W. Chow
ALK+ histiocytosis: a novel type of systemic histiocytic proliferative disorder of early infancy
Blood,
October 1, 2008;
112(7):
2965 - 2968.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Prakash and S. H Swerdlow
Nodal aggressive B-cell lymphomas: a diagnostic approach
J. Clin. Pathol.,
October 1, 2007;
60(10):
1076 - 1085.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. M. Amin and R. Lai
Pathobiology of ALK+ anaplastic large-cell lymphoma
Blood,
October 1, 2007;
110(7):
2259 - 2267.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Wan, M. S. Albom, L. Lu, M. R. Quail, N. C. Becknell, L. R. Weinberg, D. R. Reddy, B. P. Holskin, T. S. Angeles, T. L. Underiner, et al.
Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells
Blood,
February 15, 2006;
107(4):
1617 - 1623.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Teruya-Feldstein, E. Chiao, D. A. Filippa, O. Lin, R. Comenzo, M. Coleman, C. Portlock, and A. Noy
CD20-negative large-cell lymphoma with plasmablastic features: a clinically heterogenous spectrum in both HIV-positive and -negative patients
Ann. Onc.,
November 1, 2004;
15(11):
1673 - 1679.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Cussac, C. Greenland, S. Roche, R.-Y. Bai, J. Duyster, S. W. Morris, G. Delsol, M. Allouche, and B. Payrastre
Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity
Blood,
February 15, 2004;
103(4):
1464 - 1471.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. W. Morris
ALK in NHL: To B (cell) or not to B (cell)? Characterization of the entity "ALK+ DLBCL"
Blood,
October 1, 2003;
102(7):
2316 - 2317.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. D. Gascoyne, L. Lamant, J. I. Martin-Subero, V. S. Lestou, N. L. Harris, H.-K. Muller-Hermelink, J. F. Seymour, L. J. Campbell, D. E. Horsman, I. Auvigne, et al.
ALK-positive diffuse large B-cell lymphoma is associated with Clathrin-ALK rearrangements: report of 6 cases
Blood,
October 1, 2003;
102(7):
2568 - 2573.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. De Paepe, M. Baens, H. van Krieken, B. Verhasselt, M. Stul, A. Simons, B. Poppe, G. Laureys, P. Brons, P. Vandenberghe, et al.
ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma
Blood,
October 1, 2003;
102(7):
2638 - 2641.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Chiarle, J. Z. Gong, I. Guasparri, A. Pesci, J. Cai, J. Liu, W. J. Simmons, G. Dhall, J. Howes, R. Piva, et al.
NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors
Blood,
March 1, 2003;
101(5):
1919 - 1927.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V Costes-Martineau, C Delfour, S Obled, L Lamant, G-P Pageaux, P Baldet, P Blanc, and G Delsol
Anaplastic lymphoma kinase (ALK) protein expressing lymphoma after liver transplantation: case report and literature review
J. Clin. Pathol.,
November 1, 2002;
55(11):
868 - 871.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Kutok and J. C. Aster
Molecular Biology of Anaplastic Lymphoma Kinase-Positive Anaplastic Large-Cell Lymphoma
J. Clin. Oncol.,
September 1, 2002;
20(17):
3691 - 3702.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Inagaki, J. K. C. Chan, J. W. M. Ng, M. Okabe, T. Yoshino, M. Okamoto, H. Ogawa, H. Matsushita, T. Yokose, Y. Matsuno, et al.
Primary Thymic Extranodal Marginal-Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type Exhibits Distinctive Clinicopathological and Molecular Features
Am. J. Pathol.,
April 1, 2002;
160(4):
1435 - 1443.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Gouble, S. Grazide, F. Meggetto, P. Mercier, G. Delsol, and D. Morello
A New Player in Oncogenesis: AUF1/hnRNPD Overexpression Leads to Tumorigenesis in Transgenic Mice
Cancer Res.,
March 1, 2002;
62(5):
1489 - 1495.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Falini and D. Y. Mason
Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry
Blood,
January 15, 2002;
99(2):
409 - 426.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. Zhang, P. N. Raghunath, L. Xue, M. Majewski, D. F. Carpentieri, N. Odum, S. Morris, T. Skorski, and M. A. Wasik
Multilevel Dysregulation of STAT3 Activation in Anaplastic Lymphoma Kinase-Positive T/Null-Cell Lymphoma
J. Immunol.,
January 1, 2002;
168(1):
466 - 474.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Stein, H.-D. Foss, H. Durkop, T. Marafioti, G. Delsol, K. Pulford, S. Pileri, and B. Falini
CD30+ anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features
Blood,
December 1, 2000;
96(12):
3681 - 3695.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Lamant, K. Pulford, D. Bischof, S. W. Morris, D. Y. Mason, G. Delsol, and B. Mariame
Expression of the ALK Tyrosine Kinase Gene in Neuroblastoma
Am. J. Pathol.,
May 1, 2000;
156(5):
1711 - 1721.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Falini, K. Pulford, A. Pucciarini, A. Carbone, C. De Wolf-Peeters, J. Cordell, M. Fizzotti, A. Santucci, P.-G. Pelicci, S. Pileri, et al.
Lymphomas Expressing ALK Fusion Protein(s) Other Than NPM-ALK
Blood,
November 15, 1999;
94(10):
3509 - 3515.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. D. Gascoyne, P. Aoun, D. Wu, M. Chhanabhai, B. F. Skinnider, T. C. Greiner, S. W. Morris, J. M. Connors, J. M. Vose, D. S. Viswanatha, et al.
Prognostic Significance of Anaplastic Lymphoma Kinase (ALK) Protein Expression in Adults With Anaplastic Large Cell Lymphoma
Blood,
June 1, 1999;
93(11):
3913 - 3921.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Falini, S. Pileri, P. L. Zinzani, A. Carbone, V. Zagonel, C. Wolf-Peeters, G. Verhoef, F. Menestrina, G. Todeschini, M. Paulli, et al.
ALK+ Lymphoma: Clinico-Pathological Findings and Outcome
Blood,
April 15, 1999;
93(8):
2697 - 2706.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Cordell, K. A.F. Pulford, B. Bigerna, G. Roncador, A. Banham, E. Colombo, P.-G. Pelicci, D. Y. Mason, and B. Falini
Detection of Normal and Chimeric Nucleophosmin in Human Cells
Blood,
January 15, 1999;
93(2):
632 - 642.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Falini, B. Bigerna, M. Fizzotti, K. Pulford, S. A. Pileri, G. Delsol, A. Carbone, M. Paulli, U. Magrini, F. Menestrina, et al.
ALK Expression Defines a Distinct Group of T/Null Lymphomas (""ALK Lymphomas"") with a Wide Morphological Spectrum
Am. J. Pathol.,
September 1, 1998;
153(3):
875 - 886.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Beylot-Barry, A. Groppi, B. Vergier, K. Pulford, J.P. Merlio, and t. French Study Group of Cutaneous Lymphoma
Characterization of t(2;5) Reciprocal Transcripts and Genomic Breakpoints in CD30+ Cutaneous Lymphoproliferations
Blood,
June 15, 1998;
91(12):
4668 - 4676.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Benharroch, Z. Meguerian-Bedoyan, L. Lamant, C. Amin, L. Brugieres, M.-J. Terrier-Lacombe, E. Haralambieva, K. Pulford, S. Pileri, S. W. Morris, et al.
ALK-Positive Lymphoma: A Single Disease With a Broad Spectrum of Morphology
Blood,
March 15, 1998;
91(6):
2076 - 2084.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
