|
|
 Previous Article | Table of Contents | Next Article 
Vascular endothelial growth factor, a possible paracrine growth factor in
human acute myeloid leukemia
W Fiedler, U Graeven, S Ergun, S Verago, N Kilic, M Stockschlader and DK Hossfeld
Department of Hematology/Oncology, University Hospital Eppendorf, Hamburg,
Germany.
Vascular endothelial growth factor (VEGF) is a multifunctional cytokine
involved in angiogenesis, inflammation, and wound healing. It is secreted
by a variety of tumor cell lines, including hematopoietic lines. Therefore,
we investigated expression of VEGF and its receptors on fresh leukemic
blasts. VEGF-specific transcripts were detected by polymerase chain
reaction (PCR) in 20 of 28 patients with de novo acute myeloid leukemia
(AML) and in 3 of 5 patients with secondary AML. Using immunocytochemistry,
we found VEGF protein in 2 leukemic cell lines and in 8 AML patients, in
concordance with PCR results. Supernatants of fresh leukemic cells from 24
AML patients contained significantly more VEGF than supernatants from bone
marrow cells of 9 normal donors or of CD34-enriched cells from 3 normal
volunteer donors as determined by an enzyme-linked immunosorbent assay.
VEGF possesses two high-affinity receptors, KDR and FLT1. Using a sensitive
nested PCR assay, we detected expression of FLT1 in 10 of 20 patients with
de novo AML and 3 of 5 patients with secondary AML. KDR was expressed in 4
of 22 patients with de novo AML and 1 of 4 with secondary AML. To study
possible paracrine growth stimulation of AML blasts, endothelial cells from
human umbilical cords were incubated with increasing concentrations of
VEGF. A dose-dependent increase of granulocyte-macrophage colony-
stimulating factor secretion from endothelial cells was identified.
Volume 89,
Issue 6,
pp. 1870-1875,
03/15/1997
Copyright © 1997 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
D. H. Kim, W. Xu, S. Kamel-Reid, X. Liu, C. W. Jung, S. Kim, and J. H. Lipton
Clinical relevance of vascular endothelial growth factor (VEGFA) and VEGF receptor (VEGFR2) gene polymorphism on the treatment outcome following imatinib therapy
Ann. Onc.,
October 29, 2009;
(2009)
mdp452v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Rahimi, T. E. Golde, and R. D. Meyer
Identification of Ligand-Induced Proteolytic Cleavage and Ectodomain Shedding of VEGFR-1/FLT1 in Leukemic Cancer Cells
Cancer Res.,
March 15, 2009;
69(6):
2607 - 2614.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Kumpers, C. Koenecke, H. Hecker, J. Hellpap, R. Horn, W. Verhagen, S. Buchholz, B. Hertenstein, J. Krauter, M. Eder, et al.
Angiopoietin-2 predicts disease-free survival after allogeneic stem cell transplantation in patients with high-risk myeloid malignancies
Blood,
September 1, 2008;
112(5):
2139 - 2148.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. D. Jani, N. Singh, C. Jenkins, S. Raghava, Y. Mo, S. Amin, U. B. Kompella, and B. K. Ambati
Nanoparticles Sustain Expression of Flt Intraceptors in the Cornea and Inhibit Injury-Induced Corneal Angiogenesis
Invest. Ophthalmol. Vis. Sci.,
May 1, 2007;
48(5):
2030 - 2036.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Kulimova, E. Oelmann, G. Bisping, J. Kienast, R. M. Mesters, J. Schwable, F. Hilberg, G. J. Roth, G. Munzert, M. Stefanic, et al.
Growth inhibition and induction of apoptosis in acute myeloid leukemia cells by new indolinone derivatives targeting fibroblast growth factor, platelet-derived growth factor, and vascular endothelial growth factor receptors
Mol. Cancer Ther.,
December 1, 2006;
5(12):
3105 - 3112.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Singh, P. D. Jani, T. Suthar, S. Amin, and B. K. Ambati
Flt-1 Intraceptor Induces the Unfolded Protein Response, Apoptotic Factors, and Regression of Murine Injury-Induced Corneal Neovascularization
Invest. Ophthalmol. Vis. Sci.,
November 1, 2006;
47(11):
4787 - 4793.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Indraccolo, L. Stievano, S. Minuzzo, V. Tosello, G. Esposito, E. Piovan, R. Zamarchi, L. Chieco-Bianchi, and A. Amadori
Interruption of tumor dormancy by a transient angiogenic burst within the tumor microenvironment.
PNAS,
March 14, 2006;
103(11):
4216 - 4221.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Larrivee, I. Pollet, and A. Karsan
Activation of Vascular Endothelial Growth Factor Receptor-2 in Bone Marrow Leads to Accumulation of Myeloid Cells: Role of Granulocyte-Macrophage Colony-Stimulating Factor
J. Immunol.,
September 1, 2005;
175(5):
3015 - 3024.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Chavez-MacGregor, A. Aviles-Salas, D. Green, A. Fuentes-Alburo, C. Gomez-Ruiz, and A. Aguayo
Angiogenesis in the Bone Marrow of Patients with Breast Cancer
Clin. Cancer Res.,
August 1, 2005;
11(15):
5396 - 5400.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Singh, S. Amin, E. Richter, S. Rashid, V. Scoglietti, P. D. Jani, J. Wang, R. Kaur, J. Ambati, Z. Dong, et al.
Flt-1 Intraceptors Inhibit Hypoxia-Induced VEGF Expression In Vitro and Corneal Neovascularization In Vivo
Invest. Ophthalmol. Vis. Sci.,
May 1, 2005;
46(5):
1647 - 1652.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Loges, G. Heil, M. Bruweleit, V. Schoder, M. Butzal, U. Fischer, U. M. Gehling, G. Schuch, D. K. Hossfeld, and W. Fiedler
Analysis of Concerted Expression of Angiogenic Growth Factors in Acute Myeloid Leukemia: Expression of Angiopoietin-2 Represents an Independent Prognostic Factor for Overall Survival
J. Clin. Oncol.,
February 20, 2005;
23(6):
1109 - 1117.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Podar and K. C. Anderson
The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications
Blood,
February 15, 2005;
105(4):
1383 - 1395.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Fiedler, H. Serve, H. Dohner, M. Schwittay, O. G. Ottmann, A.-M. O'Farrell, C. L. Bello, R. Allred, W. C. Manning, J. M. Cherrington, et al.
A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease
Blood,
February 1, 2005;
105(3):
986 - 993.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. LeCouter, C. Zlot, M. Tejada, F. Peale, and N. Ferrara
Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization
PNAS,
November 30, 2004;
101(48):
16813 - 16818.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. K. Lee, N. D. Bone, A. K. Strege, T. D. Shanafelt, D. F. Jelinek, and N. E. Kay
VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia
Blood,
August 1, 2004;
104(3):
788 - 794.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. E. Karp, I. Gojo, R. Pili, C. D. Gocke, J. Greer, C. Guo, D. Qian, L. Morris, M. Tidwell, H. Chen, et al.
Targeting Vascular Endothelial Growth Factor for Relapsed and Refractory Adult Acute Myelogenous Leukemias: Therapy with Sequential 1-{beta}-D-Arabinofuranosylcytosine, Mitoxantrone, and Bevacizumab
Clin. Cancer Res.,
June 1, 2004;
10(11):
3577 - 3585.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Bompais, J. Chagraoui, X. Canron, M. Crisan, X. H. Liu, A. Anjo, C. Tolla-Le Port, M. Leboeuf, P. Charbord, A. Bikfalvi, et al.
Human endothelial cells derived from circulating progenitors display specific functional properties compared with mature vessel wall endothelial cells
Blood,
April 1, 2004;
103(7):
2577 - 2584.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. E. Lancet and J. E. Karp
Farnesyltransferase inhibitors in hematologic malignancies: new horizons in therapy
Blood,
December 1, 2003;
102(12):
3880 - 3889.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Meshinchi, D. L. Stirewalt, T. A. Alonzo, Q. Zhang, D. A. Sweetser, W. G. Woods, I. D. Bernstein, R. J. Arceci, and J. P. Radich
Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia
Blood,
August 15, 2003;
102(4):
1474 - 1479.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. J. Giles, A. T. Stopeck, L. R. Silverman, J. E. Lancet, M. A. Cooper, A. L. Hannah, J. M. Cherrington, A.-M. O'Farrell, H. A. Yuen, S. G. Louie, et al.
SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes
Blood,
August 1, 2003;
102(3):
795 - 801.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Wachsberger, R. Burd, and A. P. Dicker
Tumor Response to Ionizing Radiation Combined with Antiangiogenesis or Vascular Targeting Agents: Exploring Mechanisms of Interaction
Clin. Cancer Res.,
June 1, 2003;
9(6):
1957 - 1971.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-J. YIN, Z. SALAH, M. MAOZ, S. C. E. RAM, S. OCHAYON, G. NEUFELD, S. KATZAV, and R. BAR-SHAVIT
Oncogenic transformation induces tumor angiogenesis: a role for PAR1 activation
FASEB J,
February 1, 2003;
17(2):
163 - 174.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Schuch, M. Machluf, G. Bartsch Jr, M. Nomi, H. Richard, A. Atala, and S. Soker
In vivo administration of vascular endothelial growth factor (VEGF) and its antagonist, soluble neuropilin-1, predicts a role of VEGF in the progression of acute myeloid leukemia in vivo
Blood,
December 15, 2002;
100(13):
4622 - 4628.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. M. Stone
The Difficult Problem of Acute Myeloid Leukemia in the Older Adult
CA Cancer J Clin,
November 1, 2002;
52(6):
363 - 371.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. S. J. M. de Bont, V. Fidler, T. Meeuwsen, F. Scherpen, K. Hahlen, and W. A. Kamps
Vascular Endothelial Growth Factor Secretion Is an Independent Prognostic Factor for Relapse-free Survival in Pediatric Acute Myeloid Leukemia Patients
Clin. Cancer Res.,
September 1, 2002;
8(9):
2856 - 2861.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. M. Rimsza, K. P. Ahrens, J. K. Massey, K. M. Pastos, M. G. Mainwaring, and R. C. Braylan
AML, angiogenesis, and prognostic variables
Blood,
July 30, 2002;
100(4):
1517 - 1518.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Dias, S. V. Shmelkov, G. Lam, and S. Rafii
VEGF165 promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition
Blood,
April 1, 2002;
99(7):
2532 - 2540.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Dias, M. Choy, K. Alitalo, and S. Rafii
Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy
Blood,
March 15, 2002;
99(6):
2179 - 2184.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Verstovsek, H. Kantarjian, T. Manshouri, J. Cortes, F. J. Giles, A. Rogers, and M. Albitar
Prognostic significance of cellular vascular endothelial growth factor expression in chronic phase chronic myeloid leukemia
Blood,
March 15, 2002;
99(6):
2265 - 2267.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. B. Steins, T. Padro, R. Bieker, S. Ruiz, M. Kropff, J. Kienast, T. Kessler, T. Buechner, W. E. Berdel, and R. M. Mesters
Efficacy and safety of thalidomide in patients with acute myeloid leukemia
Blood,
February 1, 2002;
99(3):
834 - 839.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. F. List, K. J. Kopecky, C. L. Willman, D. R. Head, D. L. Persons, M. L. Slovak, R. Dorr, C. Karanes, H. E. Hynes, J. H. Doroshow, et al.
Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study
Blood,
December 1, 2001;
98(12):
3212 - 3220.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Koomagi, F. Zintl, A. Sauerbrey, and M. Volm
Vascular Endothelial Growth Factor in Newly Diagnosed and Recurrent Childhood Acute Lymphoblastic Leukemia as Measured by Real-Time Quantitative Polymerase Chain Reaction
Clin. Cancer Res.,
November 1, 2001;
7(11):
3381 - 3384.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. F. List
Vascular Endothelial Growth Factor Signaling Pathway as an Emerging Target in Hematologic Malignancies
Oncologist,
October 1, 2001;
6(2008):
24 - 31.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. J. Giles
The Vascular Endothelial Growth Factor (VEGF) Signaling Pathway: A Therapeutic Target in Patients with Hematologic Malignancies
Oncologist,
October 1, 2001;
6(2008):
32 - 39.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Dias, K. Hattori, B. Heissig, Z. Zhu, Y. Wu, L. Witte, D. J. Hicklin, M. Tateno, P. Bohlen, M. A. S. Moore, et al.
Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias
PNAS,
September 11, 2001;
98(19):
10857 - 10862.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Hayashibara, Y. Yamada, T. Miyanishi, H. Mori, T. Joh, T. Maeda, N. Mori, T. Maita, S. Kamihira, and M. Tomonaga
Vascular Endothelial Growth Factor and Cellular Chemotaxis: A Possible Autocrine Pathway in Adult T-Cell Leukemia Cell Invasion
Clin. Cancer Res.,
September 1, 2001;
7(9):
2719 - 2726.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. H. Mangi, W. T. Bellamy, T. M. Grogan, and A. F. List
Misleading information about ALIP and VEGF in myelodysplasia
Blood,
August 15, 2001;
98(4):
1272 - 1273.
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Podar, Y.-T. Tai, F. E. Davies, S. Lentzsch, M. Sattler, T. Hideshima, B. K. Lin, D. Gupta, Y. Shima, D. Chauhan, et al.
Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration
Blood,
July 15, 2001;
98(2):
428 - 435.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. M. Mesters, T. Padro, R. Bieker, M. Steins, M. Kreuter, M. Goner, S. Kelsey, P. Scigalla, W. Fiedler, T. Buchner, et al.
Stable remission after administration of the receptor tyrosine kinase inhibitor SU5416 in a patient with refractory acute myeloid leukemia
Blood,
July 1, 2001;
98(1):
241 - 243.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. Kini, L. C. Peterson, M. S. Tallman, and M. W. Lingen
Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid
Blood,
June 15, 2001;
97(12):
3919 - 3924.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Majka, A. Janowska-Wieczorek, J. Ratajczak, K. Ehrenman, Z. Pietrzkowski, M. A. Kowalska, A. M. Gewirtz, S. G. Emerson, and M. Z. Ratajczak
Numerous growth factors, cytokines, and chemokines are secreted by human CD34+ cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner
Blood,
May 15, 2001;
97(10):
3075 - 3085.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Wellmann, T. Taube, K. Paal, H. Graf v. Einsiedel, W. Geilen, G. Seifert, C. Eckert, G. Henze, and K. Seeger
Specific Reverse Transcription-PCR Quantification of Vascular Endothelial Growth Factor (VEGF) Splice Variants by LightCycler Technology
Clin. Chem.,
April 1, 2001;
47(4):
654 - 660.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Ferrajoli, T. Manshouri, Z. Estrov, M. J. Keating, S. O’Brien, S. Lerner, M. Beran, H. M. Kantarjian, E. J. Freireich, and M. Albitar
High Levels of Vascular Endothelial Growth Factor Receptor-2 Correlate with Shortened Survival in Chronic Lymphocytic Leukemia
Clin. Cancer Res.,
April 1, 2001;
7(4):
795 - 799.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
B. D. Smolich, H. A. Yuen, K. A. West, F. J. Giles, M. Albitar, and J. M. Cherrington
The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts
Blood,
March 1, 2001;
97(5):
1413 - 1421.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. T. Bellamy, L. Richter, D. Sirjani, C. Roxas, B. Glinsmann-Gibson, Y. Frutiger, T. M. Grogan, and A. F. List
Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes
Blood,
March 1, 2001;
97(5):
1427 - 1434.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Klasa, A. F. List, and B. D. Cheson
Rational Approaches to Design of Therapeutics Targeting Molecular Markers
Hematology,
January 1, 2001;
2001(1):
443 - 462.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Aguayo, H. Kantarjian, T. Manshouri, C. Gidel, E. Estey, D. Thomas, C. Koller, Z. Estrov, S. O'Brien, M. Keating, et al.
Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes
Blood,
September 15, 2000;
96(6):
2240 - 2245.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. J. Roboz, S. Dias, G. Lam, W. J. Lane, S. L. Soignet, R. P. Warrell Jr, and S. Rafii
Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis
Blood,
August 15, 2000;
96(4):
1525 - 1530.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Aguayo, S. O'Brien, M. Keating, T. Manshouri, C. Gidel, B. Barlogie, M. Beran, C. Koller, H. Kantarjian, and M. Albitar
Clinical relevance of intracellular vascular endothelial growth factor levels in B-cell chronic lymphocytic leukemia
Blood,
July 15, 2000;
96(2):
768 - 770.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. W. Griffioen and G. Molema
Angiogenesis: Potentials for Pharmacologic Intervention in the Treatment of Cancer, Cardiovascular Diseases, and Chronic Inflammation
Pharmacol. Rev.,
June 1, 2000;
52(2):
237 - 268.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Fusetti, G. Pruneri, A. Gobbi, C. Rabascio, N. Carboni, F. Peccatori, G. Martinelli, and F. Bertolini
Human Myeloid and Lymphoid Malignancies in the Non-Obese Diabetic/Severe Combined Immunodeficiency Mouse Model: Frequency of Apoptotic Cells in Solid Tumors and Efficiency and Speed of Engraftment Correlate with Vascular Endothelial Growth Factor Production
Cancer Res.,
May 1, 2000;
60(9):
2527 - 2534.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
B. Dankbar, T. Padro, R. Leo, B. Feldmann, M. Kropff, R. M. Mesters, H. Serve, W. E. Berdel, and J. Kienast
Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma
Blood,
April 15, 2000;
95(8):
2630 - 2636.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Padro, S. Ruiz, R. Bieker, H. Burger, M. Steins, J. Kienast, T. Buchner, W. E. Berdel, and R. M. Mesters
Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia
Blood,
April 15, 2000;
95(8):
2637 - 2644.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Veikkola, M. Karkkainen, L. Claesson-Welsh, and K. Alitalo
Regulation of Angiogenesis via Vascular Endothelial Growth Factor Receptors
Cancer Res.,
January 1, 2000;
60(2):
203 - 212.
[Full Text]
|
|
|
|
|
|
|
J. W. Hussong, G. M. Rodgers, and P. J. Shami
Evidence of increased angiogenesis in patients with acute myeloid leukemia
Blood,
January 1, 2000;
95(1):
309 - 313.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Aguayo, E. Estey, H. Kantarjian, T. Mansouri, C. Gidel, M. Keating, F. Giles, Z. Estrov, B. Barlogie, and M. Albitar
Cellular Vascular Endothelial Growth Factor Is a Predictor of Outcome in Patients With Acute Myeloid Leukemia
Blood,
December 1, 1999;
94(11):
3717 - 3721.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. G.S. Chirivi, G. Taraboletti, M. R. Bani, L. Barra, G. Piccinini, M. Giacca, F. Bussolino, and R. Giavazzi
Human Immunodeficiency Virus-1 (HIV-1)-Tat Protein Promotes Migration of Acquired Immunodeficiency Syndrome-Related Lymphoma Cells and Enhances Their Adhesion to Endothelial Cells
Blood,
September 1, 1999;
94(5):
1747 - 1754.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Vinante, A. Rigo, E. Papini, M. A. Cassatella, and G. Pizzolo
Heparin-Binding Epidermal Growth Factor-Like Growth Factor/Diphtheria Toxin Receptor Expression by Acute Myeloid Leukemia Cells
Blood,
March 1, 1999;
93(5):
1715 - 1723.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. T. Bellamy, L. Richter, Y. Frutiger, and T. M. Grogan
Expression of Vascular Endothelial Growth Factor and Its Receptors in Hematopoietic Malignancies
Cancer Res.,
February 1, 1999;
59(3):
728 - 733.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Shirafuji, S. Takahashi, S. Matsuda, and S. Asano
Mitochondrial Antisense RNA for Cytochrome C Oxidase (MARCO) Can Induce Morphologic Changes and Cell Death in Human Hematopoietic Cell Lines
Blood,
December 1, 1997;
90(11):
4567 - 4577.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
