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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Machii, T. Articles by Kitani, T. Search for Related Content PubMed PubMed Citation Articles by Machii, T. Articles by Kitani, T. Related Collections Neoplasia Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Polyclonal B-cell lymphocytosis with features resembling hairy cell leukemia-Japanese variant T Machii, M Yamaguchi, R Inoue, Y Tokumine, H Kuratsune, H Nagai, S Fukuda, K Furuyama, O Yamada, Y Yahata and T Kitani Department of Hematology and Oncology, Osaka University Medical School, Japan. Polyclonal B lymphocytosis was found in four patients having clinical and hematologic features resembling those of hairy cell leukemia (HCL). All four patients were women between 37 and 67 years of age. Three patients had splenomegaly. Lymphadenopthy was absent or slight. Persistent lymphocytosis was seen in all the patients, and anemia and/or thrombopenia was observed in three of the patients. Abnormal lymphocytes have long microvilli and prominent membranous ruffles on their surfaces. Bone marrow aspirates and biopsy specimens showed increased numbers of abnormal lymphocytes with round nuclei and abundant pale cytoplasm. Although these findings were similar to those of HCL, studies of Ig gene rearrangements and expression showed the polyclonal proliferation of B cells. We called this new disease hairy B- cell lymphoproliferative disorder (HBLD). All four patients exhibited a polyclonal increase in serum IgG. The morphology of the cells in HBLD was more similar to that of leukemia cells of a variant form of HCL (HCL-Japanese variant) than to typical HCL cells. The surface IgG+, CD5- , CD11c+, CD22+, CD24-, CD25- phenotype and the weak tartrate-resistant acid phosphatase activity in the cells were identical to those of HCL cells of the Japanese variant. Our findings suggest that the B cells in HBLD are the nonmalignant counterpart of leukemic B cells in HCL- Japanese variant. Volume 89, Issue 6, pp. 2008-2014, 03/15/1997 Copyright © 1997 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: X. Troussard, H. Mossafa, G. Flandrin;, T. Machii, M. Yamaguchi, R. Inoue, Y. Tokumine, H. Kuratsune AUTHOR=Hiroshi Nagai, S. Fukuda AUTHOR=Kazumichi Furuyama A, and Y. Yawata AUTHOR=Teruo Kitani Identity Between Hairy B-Cell Lymphoproliferative Disorder and Persistent Polyclonal B Lymphocytosis? Blood, September 1, 1997; 90(5): 2110 - 2113. [Full Text] [PDF]

	Copyright © 1997 by American Society of Hematology         Online ISSN: 1528-0020