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Specific tolerance induction and transplantation: a single-day protocol
A de Vries-van der Zwan, AC Besseling, LP de Waal and CJ Boog
Department of Transplantation Immunology, Central Laboratory of the
Netherlands Red Cross Blood Transfusion Service, Amsterdam.
Bone marrow transfusion is a well-established method for induction of mixed
hematopoietic chimerism and donor-specific tolerance in animal models. This
procedure, however, is inapplicable in clinical transplantation using
cadaveric donors due to the interval (1 week to 7 months) between tolerance
induction and organ transplantation. For clinical use, it is essential that
allografts be placed at the time of bone marrow transfusion. In the present
study, we performed skin transplantation within 1 hour after a nonlethal
conditioning regimen. Recipient mice were treated with anti-CD3, anti-CD4,
low-dose total body irradiation (3 to 6 Gy TBI) and fully mismatched or
haploidentical donor bone marrow cells. Stable multilineage chimerism and
specific T- cell nonresponsiveness developed. Donor skin grafts were
permanently accepted. These results suggest that this single day protocol
has clear potential for application in both cadaveric and living-related
organ transplantation.
Volume 89,
Issue 7,
pp. 2596-2601,
04/01/1997
Copyright © 1997 by The American Society of Hematology
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