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p53 is not required for regulation of apoptosis or radioprotection by
interleukin-3
A Silva, A Wyllie and MK Collins
CRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories,
London, UK.
Primary interleukin-3 (IL-3)-dependent mast cell cultures from bone marrow
of p53-null mice and littermate controls were established. Both p53-null
and wild-type cells entered apoptosis on IL-3 removal, showing that p53 is
not required for entry into apoptosis after factor deprivation. After
X-irradiation, a lower proportion of the p53-null than wild-type cells
underwent G2 arrest, but their radiosensitivity was similar. An
IL-3-dependent cell line expressing wild-type p53 was used to show that
cells die at a fixed time after X-irradiation rather than from a specific
cell cycle point.
Volume 89,
Issue 8,
pp. 2717-2722,
04/15/1997
Copyright © 1997 by The American Society of Hematology
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