|
|
 Previous Article | Table of Contents | Next Article 
Differential effects of interleukin-13 on cytomegalovirus and human
immunodeficiency virus infection in human alveolar macrophages
WC Hatch, AR Freedman, DM Boldt-Houle, JE Groopman and EF Terwilliger
Division of Experimental Medicine, Beth Israel Deaconess Medical Center,
Harvard Medical School, Boston, MA 02215, USA.
Alveolar macrophages, which form a principal line of defense against a
variety of pulmonary pathogens, may themselves be infected by viruses like
human immunodeficiency virus-1 (HIV-1), which impair their defensive
functions. Interleukin-13 (IL-13), a multifunctional cytokine, has been
considered for therapeutic use based on its potent inhibition of HIV-1 in
these cells. We have further examined the effects of IL-13 on alveolar
macrophages under conditions that reflect those seen in acquired immune
deficiency syndrome, where this cell type is often infected by the
opportunistic pathogen human cytomegalovirus (HCMV). Alveolar macrophages
exposed to both HCMV and HIV-1 consistently exhibited higher levels of
HIV-1 replication than cells exposed to HIV-1 alone. HIV-1 production was
strongly suppressed in alveolar macrophages treated with IL-13 regardless
of whether or not the cultures were coinfected with HCMV. However, IL-13
treatment markedly enhanced the expression of HCMV in otherwise latently
infected macrophages in a dose dependent manner. These unexpected
differential effects of IL-13 on host-virus interactions are important
considerations in guiding its potential therapeutic applications.
Volume 89,
Issue 9,
pp. 3443-3450,
05/01/1997
Copyright © 1997 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
E. Papasavvas, J. Sun, Q. Luo, E. C. Moore, B. Thiel, R. R. MacGregor, A. Minty, K. Mounzer, J. R. Kostman, and L. J. Montaner
IL-13 Acutely Augments HIV-Specific and Recall Responses from HIV-1-Infected Subjects In Vitro by Modulating Monocytes
J. Immunol.,
October 15, 2005;
175(8):
5532 - 5540.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. D. Chen, A. E. Fraire, I. Joris, R. M. Welsh, and L. K. Selin
Specific History of Heterologous Virus Infections Determines Anti-Viral Immunity and Immunopathology in the Lung
Am. J. Pathol.,
October 1, 2003;
163(4):
1341 - 1355.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Komuro, Y. Yokota, S. Yasuda, A. Iwamoto, and K. S. Kagawa
CSF-induced and HIV-1-mediated Distinct Regulation of Hck and C/EBP{beta} Represent a Heterogeneous Susceptibility of Monocyte-derived Macrophages to M-tropic HIV-1 Infection
J. Exp. Med.,
August 4, 2003;
198(3):
443 - 453.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Soderberg-Naucler, D. N. Streblow, K. N. Fish, J. Allan-Yorke, P. P. Smith, and J. A. Nelson
Reactivation of Latent Human Cytomegalovirus in CD14+ Monocytes Is Differentiation Dependent
J. Virol.,
August 15, 2001;
75(16):
7543 - 7554.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-M. Yang, W. C. Hatch, Z.-Y. Liu, B. Du, and J. E. Groopman
{beta}-Chemokine Induction of Activation Protein-1 and Cyclic AMP Responsive Element Activation in Human Myeloid Cells
Cell Growth Differ.,
April 1, 2001;
12(4):
211 - 221.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
Y. S Boriskin, M. Sharland, R. Dalton, G. duMont, and J. C Booth
Viral loads in dual infection with HIV-1 and cytomegalovirus
Arch. Dis. Child.,
February 1, 1999;
80(2):
132 - 136.
[Abstract]
[Full Text]
|
|
|
|
|
