|
|
 Previous Article | Table of Contents | Next Article 
Predominant Expression of Murine Bmx Tyrosine Kinase in the Granulo-Monocytic Lineage
Dominique Weil,
Mary-Anne Power,
Shirley I. Smith, and
Chung Leung Li
From the Leukaemia Foundation of Queensland Daikyo Research Unit, Queensland Institute of Medical Research, Queensland, Australia.
In the course of systematic cloning of protein tyrosine kinases (PTKs) expressed in hematopoietic stem and progenitor cells, we have identified the murine homologue of human Bmx. It encodes a protein containing the five domains characteristic of the Tec family of cytoplasmic src-related PTKs: pleckstrin homology (PH), Tec homology (TH), src homology 3 and 2 (SH3 and SH2), and tyrosine kinase (TK). In adults, Bmx expression was found primarily in bone marrow and at a lower level in lung and heart. During fetal development it was also found in the spleen at late stage of gestation and in neonates. Analysis of bone marrow subpopulations showed that Bmx was expressed in the progenitor cell population and maturing hematopoietic cells of the granulo/monocytic lineage where expression increased with maturation and differentiation. At the periphery, a high level of Bmx expression was also found in neutrophils and monocytes/macrophages. Bmx expression was not detected in the primitive hematopoietic stem cell population, and cells of the B-, T-, and erythroid-lineages. It was also not detected in most of the cell lines examined. Our results indicate that Bmx is another member of the Btk/Itk/Tec PTK family, which is predominantly expressed in the granulo-monocytic lineage within the hematopoietic system.
Blood, Vol. 90 No. 11 (December 1), 1997:
pp. 4332-4340
© 1997 by The American Society of Hematology.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J. Jongstra-Bilen, A. Puig Cano, M. Hasija, H. Xiao, C. I. E. Smith, and M. I. Cybulsky
Dual Functions of Bruton's Tyrosine Kinase and Tec Kinase during Fc{gamma} Receptor-Induced Signaling and Phagocytosis
J. Immunol.,
July 1, 2008;
181(1):
288 - 298.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Melcher, B. Unger, U. Schmidt, I. A. Rajantie, K. Alitalo, and W. Ellmeier
Essential Roles for the Tec Family Kinases Tec and Btk in M-CSF Receptor Signaling Pathways That Regulate Macrophage Survival
J. Immunol.,
June 15, 2008;
180(12):
8048 - 8056.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Paavonen, N. Ekman, M. Wirzenius, I. Rajantie, M. Poutanen, and K. Alitalo
Bmx Tyrosine Kinase Transgene Induces Skin Hyperplasia, Inflammatory Angiogenesis, and Accelerated Wound Healing
Mol. Biol. Cell,
September 1, 2004;
15(9):
4226 - 4233.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Ghannam, A. Takeda, T. Camarata, M. A. Moore, A. Viale, and N. R. Yaseen
The Oncogene Nup98-HOXA9 Induces Gene Transcription in Myeloid Cells
J. Biol. Chem.,
January 9, 2004;
279(2):
866 - 875.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C.I. Karlsson, R. Guinamard, S. Bolland, M. Sankala, R. M. Steinman, and J. V. Ravetch
Macrophages Control the Retention and Trafficking of B Lymphocytes in the Splenic Marginal Zone
J. Exp. Med.,
July 21, 2003;
198(2):
333 - 340.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Lachance, S. Levasseur, and P. H. Naccache
Chemotactic Factor-induced Recruitment and Activation of Tec Family Kinases in Human Neutrophils. IMPLICATION OF PHOSPHATIDYLINOSITOL 3-KINASES
J. Biol. Chem.,
June 7, 2002;
277(24):
21537 - 21541.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Rajantie, N. Ekman, K. Iljin, E. Arighi, Y. Gunji, J. Kaukonen, A. Palotie, M. Dewerchin, P. Carmeliet, and K. Alitalo
Bmx Tyrosine Kinase Has a Redundant Function Downstream of Angiopoietin and Vascular Endothelial Growth Factor Receptors in Arterial Endothelium
Mol. Cell. Biol.,
July 15, 2001;
21(14):
4647 - 4655.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. S. Cooney, H. Phee, A. Jacob, and K. M. Coggeshall
Signal Transduction by Human-Restricted Fc{{gamma}}RIIa Involves Three Distinct Cytoplasmic Kinase Families Leading to Phagocytosis
J. Immunol.,
July 15, 2001;
167(2):
844 - 854.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-T. Tsai, Y.-H. Su, S.-S. Fang, T.-N. Huang, Y. Qiu, Y.-S. Jou, H.-m. Shih, H.-J. Kung, and R.-H. Chen
Etk, a Btk Family Tyrosine Kinase, Mediates Cellular Transformation by Linking Src to STAT3 Activation
Mol. Cell. Biol.,
March 15, 2000;
20(6):
2043 - 2054.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
X. Wen, H. H. Lin, H.-M. Shih, H.-J. Kung, and D. K. Ann
Kinase Activation of the Non-receptor Tyrosine Kinase Etk/BMX Alone Is Sufficient to Transactivate STAT-mediated Gene Expression in Salivary and Lung Epithelial Cells
J. Biol. Chem.,
December 31, 1999;
274(53):
38204 - 38210.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. G. Tomlinson, T. Kurosaki, A. E. Berson, G. H. Fujii, J. A. Johnston, and J. B. Bolen
Reconstitution of Btk Signaling by the Atypical Tec Family Tyrosine Kinases Bmx and Txk
J. Biol. Chem.,
May 7, 1999;
274(19):
13577 - 13585.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. Corey and S. M. Anderson
Src-Related Protein Tyrosine Kinases in Hematopoiesis
Blood,
January 1, 1999;
93(1):
1 - 14.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-Y. Jui, R.-J. Tseng, X. Wen, H.-I Fang, L.-M. Huang, K.-Y. Chen, H.-J. Kung, D. K. Ann, and H.-M. Shih
Protein-tyrosine Phosphatase D1, a Potential Regulator and Effector for Tec Family Kinases
J. Biol. Chem.,
December 22, 2000;
275(52):
41124 - 41132.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-M. Wu, C.-L. Huang, H.-J. Kung, and C.-Y. F. Huang
Proteolytic Activation of Etk/Bmx Tyrosine Kinase by Caspases
J. Biol. Chem.,
May 18, 2001;
276(21):
17672 - 17678.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
