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Allogeneic Peripheral Blood Stem Cell Transplantation May Be Associated With a High Risk of Chronic Graft-Versus-Host Disease
Jan Storek,
Ted Gooley,
Muriel Siadak,
William I. Bensinger,
David G. Maloney,
Thomas R. Chauncey,
Mary Flowers,
Keith M. Sullivan,
Robert P. Witherspoon,
Scott D. Rowley,
John A. Hansen,
Rainer Storb, and
Frederick R. Appelbaum
From the Fred Hutchinson Cancer Research Center and Department of Medicine, University of Washington, Seattle, WA.
Chronic graft-versus-host disease (GVHD) is likely caused by donor T lymphocytes. Because unmodified blood stem cell grafts contain one log more T lymphocytes than unmodified marrow grafts, we evaluated the incidence of chronic GVHD in previously reported 37 blood stem cell recipients and 37 computer-matched historical control marrow recipients (Bensinger et al, Blood 88:2794, 1996). All patients have been followed until death, relapse, or occurrence of chronic GVHD or for a minimum of 2 years. In a univariable proportional hazards regression model, the relative risk of developing clinical chronic GVHD (includes clinical limited and clinical extensive disease) by 2 years posttransplant among the peripheral blood stem cell recipients compared with the marrow recipients was 2.22 (95% confidence interval, 1.04 to 4.74; P = .039). For clinical extensive chronic GVHD, the relative risk was 2.37 (95% confidence interval, 1.07 to 5.29; P = .035). In multivariable analyses, considering also the covariables of patient age, patient cytomegalovirus serostatus, and donor cytomegalovirus serostatus, the relative risks of clinical chronic GVHD and clinical extensive chronic GVHD were also greater than 2 (P < .05). We conclude that the transplantation of unmanipulated filgrastim-mobilized blood stem cells may result in a relatively high incidence of chronic GVHD.
Blood, Vol. 90 No. 12 (December 15), 1997:
pp. 4705-4709
© 1997 by The American Society of Hematology.
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110(8):
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175(11):
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|
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|
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T. Banovic, K. P. A. MacDonald, E. S. Morris, V. Rowe, R. Kuns, A. Don, J. Kelly, S. Ledbetter, A. D. Clouston, and G. R. Hill
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106(6):
2206 - 2214.
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|
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|
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128(1):
153 - 161.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Eapen, M. M. Horowitz, J. P. Klein, R. E. Champlin, F. R. Loberiza Jr, O. Ringden, and J. E. Wagner
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22(24):
4872 - 4880.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R.M. Nagler and A. Nagler
The Molecular Basis of Salivary Gland Involvement in Graft-vs.-Host Disease
Journal of Dental Research,
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83(2):
98 - 103.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Franzke, W. Piao, J. Lauber, P. Gatzlaff, C. Konecke, W. Hansen, A. Schmitt-Thomsen, B. Hertenstein, J. Buer, and A. Ganser
G-CSF as immune regulator in T cells expressing the G-CSF receptor: implications for transplantation and autoimmune diseases
Blood,
July 15, 2003;
102(2):
734 - 739.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Ringden, M. Labopin, A. Bacigalupo, W. Arcese, U.W. Schaefer, R. Willemze, H. Koc, D. Bunjes, E. Gluckman, V. Rocha, et al.
Transplantation of Peripheral Blood Stem Cells as Compared With Bone Marrow From HLA-Identical Siblings in Adult Patients With Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia
J. Clin. Oncol.,
December 15, 2002;
20(24):
4655 - 4664.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Yamamoto, B. Wang, S. Fukuhara, S. Ikehara, and R. A. Good
Mixed peripheral blood stem cell transplantation for autoimmune disease in BXSB/MpJ mice
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August 13, 2002;
100(5):
1886 - 1893.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Couban, D. R. Simpson, M. J. Barnett, C. Bredeson, L. Hubesch, K. Howson-Jan, T. B. Shore, I. R. Walker, P. Browett, H. A. Messner, et al.
A randomized multicenter comparison of bone marrow and peripheral blood in recipients of matched sibling allogeneic transplants for myeloid malignancies
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August 13, 2002;
100(5):
1525 - 1531.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. Lee, J. P. Klein, A. J. Barrett, O. Ringden, J. H. Antin, J.-Y. Cahn, M. H. Carabasi, R. P. Gale, S. Giralt, G. A. Hale, et al.
Severity of chronic graft-versus-host disease: association with treatment-related mortality and relapse
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June 28, 2002;
100(2):
406 - 414.
[Abstract]
[Full Text]
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|
|
|
|
|
|
|
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May 29, 2002;
99(12):
4370 - 4378.
[Abstract]
[Full Text]
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|
|
|
|
|
|
|
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J. Clin. Oncol.,
January 15, 2002;
20(2):
603 - 606.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Morton, C. Hutchins, and S. Durrant
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December 1, 2001;
98(12):
3186 - 3191.
[Abstract]
[Full Text]
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|
|
|
|
|
|
|
D. Przepiorka, P. Anderlini, R. Saliba, K. Cleary, R. Mehra, I. Khouri, Y. O. Huh, S. Giralt, I. Braunschweig, K. van Besien, et al.
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September 15, 2001;
98(6):
1695 - 1700.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Remberger, O. Ringden, I.-W. Blau, H. Ottinger, B. Kremens, M. G. Kiehl, J. Aschan, D. W. Beelen, N. Basara, G. Kumlien, et al.
No difference in graft-versus-host disease, relapse, and survival comparing peripheral stem cells to bone marrow using unrelated donors
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September 15, 2001;
98(6):
1739 - 1745.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Cutler, S. Giri, S. Jeyapalan, D. Paniagua, A. Viswanathan, and J. H. Antin
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August 15, 2001;
19(16):
3685 - 3691.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. D. Rowley, G. Donaldson, K. Lilleby, W. I. Bensinger, and F. R. Appelbaum
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May 1, 2001;
97(9):
2541 - 2548.
[Abstract]
[Full Text]
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|
|
|
|
|
|
|
V. Lapierre, N. Oubouzar, A. Auperin, D. Tramalloni, H. Tayebi, E. Robinet, M. Kuentz, D. Blaise, O. Hartmann, P. Herve, et al.
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May 1, 2001;
97(9):
2580 - 2586.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. I. Bensinger, P. J. Martin, B. Storer, R. Clift, S. J. Forman, R. Negrin, A. Kashyap, M. E.D. Flowers, K. Lilleby, T. R. Chauncey, et al.
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N. Engl. J. Med.,
January 18, 2001;
344(3):
175 - 181.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Matsubara, A. Makimoto, J. Takayama, T. Higa, T. Saito, Y. Kanda, R. Tanosaki, S. Mineishi, M. Ohira, and Y. Takaue
Possible Clinical Benefits of the Use of Peripheral Blood Stem Cells Over Bone Marrow in the Allogeneic Transplantation Setting for the Treatment of Childhood Leukemia
Jpn. J. Clin. Oncol.,
January 1, 2001;
31(1):
30 - 34.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Ozer, J. O. Armitage, C. L. Bennett, J. Crawford, G. D. Demetri, P. A. Pizzo, C. A. Schiffer, T. J. Smith, G. Somlo, J. C. Wade, et al.
2000 Update of Recommendations for the Use of Hematopoietic Colony-Stimulating Factors: Evidence-Based, Clinical Practice Guidelines
J. Clin. Oncol.,
October 20, 2000;
18(20):
3558 - 3585.
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Ratanatharathorn, E. Carson, C. Reynolds, L. J. Ayash, J. Levine, G. Yanik, S. M. Silver, J. L.M. Ferrara, and J. P. Uberti
Anti-CD20 Chimeric Monoclonal Antibody Treatment of Refractory Immune-Mediated Thrombocytopenia in a Patient with Chronic Graft-versus-Host Disease
Ann Intern Med,
August 15, 2000;
133(4):
275 - 279.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. E. Champlin, N. Schmitz, M. M. Horowitz, B. Chapuis, R. Chopra, J. J. Cornelissen, R. P. Gale, J. M. Goldman, F. R. Loberiza Jr, B. Hertenstein, et al.
Blood stem cells compared with bone marrow as a source of hematopoietic cells for allogeneic transplantation
Blood,
June 15, 2000;
95(12):
3702 - 3709.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Arpinati, C. L. Green, S. Heimfeld, J. E. Heuser, and C. Anasetti
Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells
Blood,
April 15, 2000;
95(8):
2484 - 2490.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Siena, R. Schiavo, P. Pedrazzoli, and C. Carlo-Stella
Therapeutic Relevance of CD34 Cell Dose in Blood Cell Transplantation for Cancer Therapy
J. Clin. Oncol.,
March 13, 2000;
18(6):
1360 - 1377.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Blaise, M. Kuentz, C. Fortanier, J. H. Bourhis, N. Milpied, L. Sutton, J.-P. Jouet, M. Attal, P. Bordigoni, J.-Y. Cahn, et al.
Randomized Trial of Bone Marrow Versus Lenograstim-Primed Blood Cell Allogeneic Transplantation in Patients With Early-Stage Leukemia: A Report From the Societe Francaise de Greffe de Moelle
J. Clin. Oncol.,
February 1, 2000;
18(3):
537 - 537.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. R. Appelbaum
Choosing the Source of Stem Cells for Allogeneic Transplantation: No Longer a Peripheral Issue
Blood,
July 15, 1999;
94(2):
381 - 383.
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Ringden, M. Remberger, V. Runde, M. Bornhauser, I.W. Blau, N. Basara, K. Holig, D.W. Beelen, H. Hagglund, O. Basu, et al.
Peripheral Blood Stem Cell Transplantation From Unrelated Donors: A Comparison With Marrow Transplantation
Blood,
July 15, 1999;
94(2):
455 - 464.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Engelhardt, H. Bertz, M. Afting, C. F. Waller, and J. Finke
High- Versus Standard-Dose Filgrastim (rhG-CSF) for Mobilization of Peripheral-Blood Progenitor Cells From Allogeneic Donors and CD34+ Immunoselection
J. Clin. Oncol.,
July 1, 1999;
17(7):
2160 - 2160.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Pan, T. Teshima, G. R. Hill, D. Bungard, Y. S. Brinson, V. S. Reddy, K. R. Cooke, and J. L.M. Ferrara
Granulocyte Colony-Stimulating Factor-Mobilized Allogeneic Stem Cell Transplantation Maintains Graft-Versus-Leukemia Effects Through a Perforin-Dependent Pathway While Preventing Graft-Versus-Host Disease
Blood,
June 15, 1999;
93(12):
4071 - 4078.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. K. Burt
Clinical Utility in Maximizing CD34+ Cell Count in Stem Cell Grafts
Oncologist,
June 1, 1999;
4(3):
265 - 268.
[Full Text]
|
|
|
|
|
|
|
M. N. Yenerel, D. Sargin, and Y. Tangun
High Risk of Chronic Graft-Versus-Host Disease in Unmanipulated Allogeneic Peripheral Blood Stem Cell Transplantation
Blood,
October 15, 1998;
92(8):
2973 - 2975.
[Full Text]
[PDF]
|
|
|
|
|
