|
|
 Previous Article | Table of Contents | Next Article 
Lymphomas in Patients With Sjögren's Syndrome Are Marginal Zone B-Cell Neoplasms, Arise in Diverse Extranodal and Nodal Sites, and Are Not Associated With Viruses
Bruno Royer,
Dominique Cazals-Hatem,
Jean Sibilia,
Felix Agbalika,
Jean-Michel Cayuela,
Thierry Soussi,
Frédéric Maloisel,
Jean-Pierre Clauvel,
Jean-Claude Brouet, and
Xavier Mariette
From the Service d'Immuno-Hématologie, Laboratoire d'Anatomopathologie, Service de Bactério-Virologie, INSERM U 93-Immunogénétique de la transplantation, U301 INSERM-Génétique cellulaire et moléculaire des leucémies-IGM-Hôpital Saint-Louis, Paris, France; and the Service de Rhumatologie and the Service d'Hématologie, Hôpital de Hautepierre, Strasbourg, France.
The occurrence of non-Hodgkin's lymphoma (NHL) is the most serious complication of Sjögren's syndrome (SS). We performed a study of 16 NHLs occurring in patients with an underlying SS. These lymphomas arose not only in salivary glands (7 cases) but also in other mucosal extranodal sites (the stomach [4 cases], the lung [3 cases], the skin [3 cases], the buccal mucosa [1 case], the thymus [1 case]) and in nodal sites (8 cases). Low-grade marginal zone lymphomas (MZL) were diagnosed in 12 of the 16 patients, 9 of mucosa-associated lymphoid tissues (MALT) type in mucosal sites and 3 exclusively nodal. The 4 other patients presented with a high-grade B-cell lymphoma that was probably a histological transformation of an underlying low-grade MZL at least in 3 of the cases involving skin, stomach, and parotid, respectively. A t(14; 18) translocation was detected in 1 of 8 lymphomas tested. We detected serum anti-p53 antibodies in 2 of the 14 studied patients. p53 protein was detected in 1 of 11 lymphomas tested. LMP protein and Eber RNAs of Epstein-Barr virus (EBV) were not detected in the 16 NHL biopsies. Using polymerase chain reaction, EBV was never detected except in 1 of 4 parotid lymphomas. No human T-lymphotropic virus 1 or human herpes virus 8 DNAs were detected in NHL biopsies. None of the patients had hepatitis C virus infection found using serological methods. Chemotherapy was usually efficient. In conclusion, lymphomas occurring in patients with an underlying SS are in most cases MZL. These lymphomas are not associated with viruses known to be present in other types of lymphomas. Some of the translocations or mutations of oncogenes or antioncogenes described in other lymphomas are detected in SS-associated lymphomas.
Blood, Vol. 90 No. 2 (July 15), 1997:
pp. 766-775
© 1997 by The American Society of Hematology.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. Colombat, H. Mal, C. Copie-Bergman, J. Diebold, D. Damotte, P. Callard, M. Fournier, J.-P. Farcet, M. Stern, and M.-H. Delfau-Larue
Primary cystic lung light chain deposition disease: a clinicopathologic entity derived from unmutated B cells with a stereotyped IGHV4-34/IGKV1 receptor
Blood,
September 1, 2008;
112(5):
2004 - 2012.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Korst
Primary Lymphoma of the Subglottic Airway in a Patient With Sjogren's Syndrome Mimicking High Laryngotracheal Stenosis
Ann. Thorac. Surg.,
November 1, 2007;
84(5):
1756 - 1758.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Bombardieri, F. Barone, F. Humby, S. Kelly, M. McGurk, P. Morgan, S. Challacombe, S. De Vita, G. Valesini, J. Spencer, et al.
Activation-Induced Cytidine Deaminase Expression in Follicular Dendritic Cell Networks and Interfollicular Large B Cells Supports Functionality of Ectopic Lymphoid Neogenesis in Autoimmune Sialoadenitis and MALT Lymphoma in Sjogren's Syndrome
J. Immunol.,
October 1, 2007;
179(7):
4929 - 4938.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. E. Smedby, E. Baecklund, and J. Askling
Malignant Lymphomas in Autoimmunity and Inflammation: A Review of Risks, Risk Factors, and Lymphoma Characteristics.
Cancer Epidemiol. Biomarkers Prev.,
November 1, 2006;
15(11):
2069 - 2077.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Suarez, O. Lortholary, O. Hermine, and M. Lecuit
Infection-associated lymphomas derived from marginal zone B cells: a model of antigen-driven lymphoproliferation
Blood,
April 15, 2006;
107(8):
3034 - 3044.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-E. Gottenberg, N. Cagnard, C. Lucchesi, F. Letourneur, S. Mistou, T. Lazure, S. Jacques, N. Ba, M. Ittah, C. Lepajolec, et al.
Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjogren's syndrome
PNAS,
February 21, 2006;
103(8):
2770 - 2775.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. A. Engels, J. R. Cerhan, M. S. Linet, W. Cozen, J. S. Colt, S. Davis, G. Gridley, R. K. Severson, and P. Hartge
Immune-Related Conditions and Immune-Modulating Medications as Risk Factors for Non-Hodgkin's Lymphoma: A Case-Control Study
Am. J. Epidemiol.,
December 15, 2005;
162(12):
1153 - 1161.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. J. Novak, D. M. Grote, M. Stenson, S. C. Ziesmer, T. E. Witzig, T. M. Habermann, B. Harder, K. M. Ristow, R. J. Bram, D. F. Jelinek, et al.
Expression of BLyS and its receptors in B-cell non-Hodgkin lymphoma: correlation with disease activity and patient outcome
Blood,
October 15, 2004;
104(8):
2247 - 2253.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Streubel, D. Huber, S. Wohrer, A. Chott, and M. Raderer
Frequency of Chromosomal Aberrations Involving MALT1 in Mucosa-Associated Lymphoid Tissue Lymphoma in Patients with Sjogren's Syndrome
Clin. Cancer Res.,
January 15, 2004;
10(2):
476 - 480.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. D. Aljurf, T. W. Owaidah, A. Ezzat, E. Ibrahim, and A. Tbakhi
Antigen- and/or immune-driven lymphoproliferative disorders
Ann. Onc.,
November 1, 2003;
14(11):
1595 - 1606.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Okabe, H. Inagaki, K. Ohshima, T. Yoshino, C. Li, T. Eimoto, R. Ueda, and S. Nakamura
API2-MALT1 Fusion Defines a Distinctive Clinicopathologic Subtype in Pulmonary Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue
Am. J. Pathol.,
April 1, 2003;
162(4):
1113 - 1122.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Zucca, A. Conconi, E. Pedrinis, S. Cortelazzo, T. Motta, M. K. Gospodarowicz, B. J. Patterson, A. J. M. Ferreri, M. Ponzoni, L. Devizzi, et al.
Nongastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue
Blood,
April 1, 2003;
101(7):
2489 - 2495.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. J. Novak, R. J. Bram, N. E. Kay, and D. F. Jelinek
Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukemia cells: a mechanism for survival
Blood,
September 26, 2002;
100(8):
2973 - 2979.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Tonami, M. Matoba, H. Yokota, K. Higashi, I. Yamamoto, and S. Sugai
Mucosa-Associated Lymphoid Tissue Lymphoma in Sjogren's Syndrome: Initial and Follow-Up Imaging Features
Am. J. Roentgenol.,
August 1, 2002;
179(2):
485 - 489.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Mariette, D. Cazals-Hatem, J. Warszawki, F. Liote, N. Balandraud, and J. Sibilia
Lymphomas in rheumatoid arthritis patients treated with methotrexate: a 3-year prospective study in France
Blood,
May 13, 2002;
99(11):
3909 - 3915.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Inagaki, J. K. C. Chan, J. W. M. Ng, M. Okabe, T. Yoshino, M. Okamoto, H. Ogawa, H. Matsushita, T. Yokose, Y. Matsuno, et al.
Primary Thymic Extranodal Marginal-Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type Exhibits Distinctive Clinicopathological and Molecular Features
Am. J. Pathol.,
April 1, 2002;
160(4):
1435 - 1443.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X Mariette
Lymphomas complicating Sjogren's syndrome and hepatitis C virus infection may share a common pathogenesis: chronic stimulation of rheumatoid factor B cells
Ann Rheum Dis,
November 1, 2001;
60(11):
1007 - 1011.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Miklos, S. H. Swerdlow, and D. W. Bahler
Salivary gland mucosa-associated lymphoid tissue lymphoma immunoglobulin VH genes show frequent use of V1-69 with distinctive CDR3 features
Blood,
June 15, 2000;
95(12):
3878 - 3884.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Soussi
p53 Antibodies in the Sera of Patients with Various Types of Cancer: A Review
Cancer Res.,
April 1, 2000;
60(7):
1777 - 1788.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
E. D. Remstein, C. D. James, and P. J. Kurtin
Incidence and Subtype Specificity of API2-MALT1 Fusion Translocations in Extranodal, Nodal, and Splenic Marginal Zone Lymphomas
Am. J. Pathol.,
April 1, 2000;
156(4):
1183 - 1188.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Aiello, M.-Q. Du, T. C. Diss, H.-Z. Peng, F. Pezzella, D. Papini, R. Giardini, S. Pilotti, L.-X. Pan, and P. G. Isaacson
Simultaneous Phenotypically Distinct but Clonally Identical Mucosa-Associated Lymphoid Tissue and Follicular Lymphoma in a Patient With Sjogren's Syndrome
Blood,
October 1, 1999;
94(7):
2247 - 2251.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
