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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Koene, H. R. Articles by de Haas, M. Search for Related Content PubMed PubMed Citation Articles by Koene, H. R. Articles by de Haas, M. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  FcRIIIa-158V/F Polymorphism Influences the Binding of IgG by Natural Killer Cell FcRIIIa, Independently of the FcRIIIa-48L/R/H Phenotype Harry R. Koene, Marion Kleijer, Johan Algra, Dirk Roos, Albert E.G.Kr. von dem Borne, and Masja de Haas From the Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Amsterdam; and Academic Medical Centre, Amsterdam, The Netherlands. We analyzed a genetic polymorphism of Fc receptor IIIa (CD16) that is present on position 158 (Phe or Val) in the membrane-proximal, IgG-binding domain. With a polymerase chain reaction-based allele-specific restriction analysis assay we genotyped 87 donors and found gene frequencies of 0.57 and 0.43 for FcRIIIA-158F and -158V, respectively. A clear linkage was observed between the FcRIIIA-158F and -48L genotypes on the one hand and the FcRIIIA-158V and -48H or -48R genotypes on the other hand (2 test; P < .001). To determine the functional consequences of this FcRIIIa-158V/F polymorphism, we performed IgG binding experiments with natural killer (NK) cells from genotyped donors. All donors were also typed for the recently described triallelic FcRIIIa-48L/R/H polymorphism. NK cells were treated with lactic acid to remove cell-associated IgG. FcRIIIaNK158F bound significantly less IgG1, IgG3, and IgG4 than did FcRIIIaNK-158V, irrespective of the FcRIIIa-48 phenotype. Moreover, freshly isolated NK cells from FcRIIIa-158VV individuals carried significantly more cytophilic IgG than did NK cells from FcRIIIa-158FF individuals. In addition, CD16 monoclonal antibody (MoAb) MEM154 bound more strongly to FcRIIIa-158V, compared with -158F, again independently of the FcRIIIa-48 phenotype. The binding of MoAb B73.1 was not influenced by the FcRIIIa-158V/F polymorphism, but proved to depend solely on the amino acid present at position 48 of FcRIIIa. In conclusion, the previously reported differences in IgG binding among the three FcRIIIa-48L/R/H isoforms are a consequence of the linked, biallelic FcRIIIa-158V/F polymorphism at amino-acid position 158. Blood, Vol. 90 No. 3 (August 1), 1997: pp. 1109-1114 © 1997 by The American Society of Hematology. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M M Thabet, T W J Huizinga, R B Marques, G Stoeken-Rijsbergen, A M Bakker, F A Kurreeman, S J White, R E M Toes, and A H M van der Helm-van Mil Contribution of Fc{gamma} receptor IIIA gene 158V/F polymorphism and copy number variation to the risk of ACPA-positive rheumatoid arthritis Ann Rheum Dis, November 1, 2009; 68(11): 1775 - 1780. 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Biol., December 1, 2008; 84(6): 1511 - 1520. [Abstract] [Full Text] [PDF] N. M. Pennell, T. Bhanji, L. Zhang, A. Seth, C. A. Sawka, and N. L. Berinstein Lack of prognostic value of FCGR3A-V158F polymorphism in non-Hodgkin's lymphoma Haematologica, August 1, 2008; 93(8): 1265 - 1267. [Full Text] [PDF] G. Cartron, L. Zhao-Yang, M. Baudard, T. Kanouni, V. Rouille, P. Quittet, B. Klein, and J.-F. Rossi Granulocyte-Macrophage Colony-Stimulating Factor Potentiates Rituximab in Patients With Relapsed Follicular Lymphoma: Results of a Phase II Study J. Clin. Oncol., June 1, 2008; 26(16): 2725 - 2731. [Abstract] [Full Text] [PDF] A. Musolino, N. Naldi, B. Bortesi, D. Pezzuolo, M. Capelletti, G. Missale, D. Laccabue, A. Zerbini, R. Camisa, G. Bisagni, et al. Immunoglobulin G Fragment C Receptor Polymorphisms and Clinical Efficacy of Trastuzumab-Based Therapy in Patients With HER-2/neu-Positive Metastatic Breast Cancer J. Clin. Oncol., April 10, 2008; 26(11): 1789 - 1796. [Abstract] [Full Text] [PDF] N. Congy-Jolivet, A. Bolzec, D. Ternant, M. Ohresser, H. Watier, and G. Thibault Fc{gamma}RIIIa Expression Is Not Increased on Natural Killer Cells Expressing the Fc{gamma}RIIIa-158V Allotype Cancer Res., February 15, 2008; 68(4): 976 - 980. [Abstract] [Full Text] [PDF] W. B. Breunis, E. van Mirre, M. Bruin, J. Geissler, M. de Boer, M. Peters, D. Roos, M. de Haas, H. R. Koene, and T. W. Kuijpers Copy number variation of the activating FCGR2C gene predisposes to idiopathic thrombocytopenic purpura Blood, February 1, 2008; 111(3): 1029 - 1038. [Abstract] [Full Text] [PDF] S. Varchetta, N. Gibelli, B. Oliviero, E. Nardini, R. Gennari, G. Gatti, L. S. Silva, L. Villani, E. Tagliabue, S. Menard, et al. Elements Related to Heterogeneity of Antibody-Dependent Cell Cytotoxicity in Patients Under Trastuzumab Therapy for Primary Operable Breast Cancer Overexpressing Her2 Cancer Res., December 15, 2007; 67(24): 11991 - 11999. [Abstract] [Full Text] [PDF] E. Oflazoglu, I. J. Stone, K. A. Gordon, I. S. Grewal, N. van Rooijen, C.-L. Law, and H.-P. Gerber Macrophages contribute to the antitumor activity of the anti-CD30 antibody SGN-30 Blood, December 15, 2007; 110(13): 4370 - 4372. [Abstract] [Full Text] [PDF] M. C. Ryan, M. Hering, D. Peckham, C. F. McDonagh, L. Brown, K. M. Kim, D. L. Meyer, R. F. Zabinski, I. S. Grewal, and P. J. Carter Antibody targeting of B-cell maturation antigen on malignant plasma cells Mol. Cancer Ther., November 1, 2007; 6(11): 3009 - 3018. [Abstract] [Full Text] [PDF] E. Hatjiharissi, L. Xu, D. D. Santos, Z. R. Hunter, B. T. Ciccarelli, S. Verselis, M. Modica, Y. Cao, R. J. Manning, X. Leleu, et al. Increased natural killer cell expression of CD16, augmented binding and ADCC activity to rituximab among individuals expressing the Fc{gamma}RIIIa-158 V/V and V/F polymorphism Blood, October 1, 2007; 110(7): 2561 - 2564. [Abstract] [Full Text] [PDF] S. E. Strome, E. A. Sausville, and D. Mann A Mechanistic Perspective of Monoclonal Antibodies in Cancer Therapy Beyond Target-Related Effects Oncologist, September 1, 2007; 12(9): 1084 - 1095. [Abstract] [Full Text] [PDF] Z. Mitrovic, I. Aurer, I. Radman, R. Ajdukovic, J. Sertic, and B. Labar FC{gamma}RIIIA and FC{gamma}RIIA polymorphisms are not associated with response to rituximab and CHOP in patients with diffuse large B-cell lymphoma Haematologica, July 1, 2007; 92(7): 998 - 999. [Abstract] [Full Text] [PDF] D. N. Forthal, P. B. Gilbert, G. Landucci, and T. Phan Recombinant gp120 Vaccine-Induced Antibodies Inhibit Clinical Strains of HIV-1 in the Presence of Fc Receptor-Bearing Effector Cells and Correlate Inversely with HIV Infection Rate J. Immunol., May 15, 2007; 178(10): 6596 - 6603. [Abstract] [Full Text] [PDF] S. A. Hammond, R. Lutterbuese, S. Roff, P. Lutterbuese, B. Schlereth, E. Bruckheimer, M. S. Kinch, S. Coats, P. A. Baeuerle, P. Kufer, et al. Selective Targeting and Potent Control of Tumor Growth Using an EphA2/CD3-Bispecific Single-Chain Antibody Construct Cancer Res., April 15, 2007; 67(8): 3927 - 3935. [Abstract] [Full Text] [PDF] E. Suzuki, R. Niwa, S. Saji, M. Muta, M. Hirose, S. Iida, Y. Shiotsu, M. Satoh, K. Shitara, M. Kondo, et al. A Nonfucosylated Anti-HER2 Antibody Augments Antibody-Dependent Cellular Cytotoxicity in Breast Cancer Patients Clin. Cancer Res., March 15, 2007; 13(6): 1875 - 1882. [Abstract] [Full Text] [PDF] E. Shoji-Hosaka, Y. Kobayashi, M. Wakitani, K. Uchida, R. Niwa, K. Nakamura, and K. Shitara Enhanced Fc-Dependent Cellular Cytotoxicity of Fc Fusion Proteins Derived from TNF Receptor II and LFA-3 by Fucose Removal from Asn-Linked Oligosaccharides J. Biochem., December 1, 2006; 140(6): 777 - 783. [Abstract] [Full Text] [PDF] S. Inoges, M. Rodriguez-Calvillo, N. Zabalegui, A. Lopez-Diaz de Cerio, H. Villanueva, E. Soria, L. Suarez, A. Rodriguez-Caballero, F. Pastor, R. Garcia-Munoz, et al. Clinical benefit associated with idiotypic vaccination in patients with follicular lymphoma. J Natl Cancer Inst, September 20, 2006; 98(18): 1292 - 1301. [Abstract] [Full Text] [PDF] W. F. Dall'Acqua, P. A. Kiener, and H. Wu Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn) J. Biol. Chem., August 18, 2006; 281(33): 23514 - 23524. [Abstract] [Full Text] [PDF] W. F. Dall'Acqua, K. E. Cook, M. M. Damschroder, R. M. Woods, and H. Wu Modulation of the Effector Functions of a Human IgG1 through Engineering of Its Hinge Region J. Immunol., July 15, 2006; 177(2): 1129 - 1138. [Abstract] [Full Text] [PDF] N.-K. V. Cheung, R. Sowers, A. J. Vickers, I. Y. Cheung, B. H. Kushner, and R. Gorlick FCGR2A Polymorphism Is Correlated With Clinical Outcome After Immunotherapy of Neuroblastoma With Anti-GD2 Antibody and Granulocyte Macrophage Colony-Stimulating Factor J. Clin. Oncol., June 20, 2006; 24(18): 2885 - 2890. [Abstract] [Full Text] [PDF] B. Clemenceau, N. Congy-Jolivet, G. Gallot, R. Vivien, J. Gaschet, G. Thibault, and H. Vie Antibody-dependent cellular cytotoxicity (ADCC) is mediated by genetically modified antigen-specific human T lymphocytes Blood, June 15, 2006; 107(12): 4669 - 4677. [Abstract] [Full Text] [PDF] C. Ferrara, F. Stuart, P. Sondermann, P. Brunker, and P. Umana The Carbohydrate at Fc{gamma}RIIIa Asn-162: AN ELEMENT REQUIRED FOR HIGH AFFINITY BINDING TO NON-FUCOSYLATED IgG GLYCOFORMS J. Biol. Chem., February 24, 2006; 281(8): 5032 - 5036. [Abstract] [Full Text] [PDF] P. R. Hinton, J. M. Xiong, M. G. Johlfs, M. T. Tang, S. Keller, and N. Tsurushita An Engineered Human IgG1 Antibody with Longer Serum Half-Life J. Immunol., January 1, 2006; 176(1): 346 - 356. [Abstract] [Full Text] [PDF] Y. Tanaka, Y. Suzuki, T. Tsuge, Y. Kanamaru, S. Horikoshi, R. C. Monteiro, and Y. Tomino Fc{gamma}RIIa-131R allele and Fc{gamma}RIIIa-176V/V genotype are risk factors for progression of IgA nephropathy Nephrol. Dial. Transplant., November 1, 2005; 20(11): 2439 - 2445. [Abstract] [Full Text] [PDF] M. I. Vega, A. R. Jazirehi, S. Huerta-Yepez, and B. Bonavida Rituximab-Induced Inhibition of YY1 and Bcl-xL Expression in Ramos Non-Hodgkin's Lymphoma Cell Line via Inhibition of NF-{kappa}B Activity: Role of YY1 and Bcl-xL in Fas Resistance and Chemoresistance, Respectively J. Immunol., August 15, 2005; 175(4): 2174 - 2183. [Abstract] [Full Text] [PDF] C-H Hong, J-S Lee, H-S Lee, S-C Bae, and D-H Yoo The association between FcgRIIIB polymorphisms and systemic lupus erythematosus in Korea Lupus, May 1, 2005; 14(5): 346 - 350. [Abstract] [PDF] P. Carter and C. F. McDonagh Designer Antibody-Based Therapeutics for Oncology Am. Assoc. Cancer Res. Educ. Book, April 1, 2005; 2005(1): 147 - 154. [Full Text] [PDF] R. Niwa, M. Sakurada, Y. Kobayashi, A. Uehara, K. Matsushima, R. Ueda, K. Nakamura, and K. Shitara Enhanced Natural Killer Cell Binding and Activation by Low-Fucose IgG1 Antibody Results in Potent Antibody-Dependent Cellular Cytotoxicity Induction at Lower Antigen Density Clin. Cancer Res., March 15, 2005; 11(6): 2327 - 2336. [Abstract] [Full Text] [PDF] E. E. Brown, M. D. Fallin, J. J. Goedert, R. Chen, D. Whitby, C. B. Foster, C. Lauria, A. J. Alberg, A. Messina, M. Montella, et al. A Common Genetic Variant in FCGR3A-V158F and Risk of Kaposi Sarcoma Herpesvirus Infection and Classic Kaposi Sarcoma Cancer Epidemiol. Biomarkers Prev., March 1, 2005; 14(3): 633 - 637. [Abstract] [Full Text] [PDF] S. P. Treon, M. Hansen, A. R. Branagan, S. Verselis, C. Emmanouilides, E. Kimby, S. R. Frankel, N. Touroutoglou, B. Turnbull, K. C. Anderson, et al. Polymorphisms in Fc{gamma}RIIIA (CD16) Receptor Expression Are Associated With Clinical Response to Rituximab in Waldenstrom's Macroglobulinemia J. Clin. Oncol., January 20, 2005; 23(3): 474 - 481. [Abstract] [Full Text] [PDF] W.-K. Weng, D. Czerwinski, J. Timmerman, F. J. Hsu, and R. Levy Clinical Outcome of Lymphoma Patients After Idiotype Vaccination Is Correlated With Humoral Immune Response and Immunoglobulin G Fc Receptor Genotype J. Clin. Oncol., December 1, 2004; 22(23): 4717 - 4724. [Abstract] [Full Text] [PDF] T. Ishida, S. Iida, Y. Akatsuka, T. Ishii, M. Miyazaki, H. Komatsu, H. Inagaki, N. Okada, T. Fujita, K. Shitara, et al. The CC Chemokine Receptor 4 as a Novel Specific Molecular Target for Immunotherapy in Adult T-Cell Leukemia/Lymphoma Clin. Cancer Res., November 15, 2004; 10(22): 7529 - 7539. [Abstract] [Full Text] [PDF] G. Cartron, H. Watier, J. Golay, and P. Solal-Celigny From the bench to the bedside: ways to improve rituximab efficacy Blood, November 1, 2004; 104(9): 2635 - 2642. [Abstract] [Full Text] [PDF] Y. Gruel, C. Pouplard, D. Lasne, C. Magdelaine-Beuzelin, C. Charroing, and H. Watier The homozygous Fc{gamma}RIIIa-158V genotype is a risk factor for heparin-induced thrombocytopenia in patients with antibodies to heparin-platelet factor 4 complexes Blood, November 1, 2004; 104(9): 2791 - 2793. [Abstract] [Full Text] [PDF] R. Niwa, S. Hatanaka, E. Shoji-Hosaka, M. Sakurada, Y. Kobayashi, A. Uehara, H. Yokoi, K. Nakamura, and K. Shitara Enhancement of the Antibody-Dependent Cellular Cytotoxicity of Low-Fucose IgG1 Is Independent of Fc{gamma}RIIIa Functional Polymorphism Clin. Cancer Res., September 15, 2004; 10(18): 6248 - 6255. [Abstract] [Full Text] [PDF] S. Dall'Ozzo, S. Tartas, G. Paintaud, G. Cartron, P. Colombat, P. Bardos, H. Watier, and G. Thibault Rituximab-Dependent Cytotoxicity by Natural Killer Cells: Influence of FCGR3A Polymorphism on the Concentration-Effect Relationship Cancer Res., July 1, 2004; 64(13): 4664 - 4669. [Abstract] [Full Text] [PDF] S. Miescher, M. O. Spycher, H. Amstutz, M. de Haas, M. Kleijer, U. J. Kalus, H. Radtke, A. Hubsch, I. Andresen, R. M. Martin, et al. A single recombinant anti-RhD IgG prevents RhD immunization: association of RhD-positive red blood cell clearance rate with polymorphisms in the Fc{gamma}RIIA and Fc{gamma}IIIA genes Blood, June 1, 2004; 103(11): 4028 - 4035. [Abstract] [Full Text] [PDF] W. L. Gluck, D. Hurst, A. Yuen, A. M. Levine, M. A. Dayton, J. P. Gockerman, J. Lucas, K. Denis-Mize, B. Tong, D. Navis, et al. Phase I Studies of Interleukin (IL)-2 and Rituximab in B-Cell Non-Hodgkin's Lymphoma: IL-2 Mediated Natural Killer Cell Expansion Correlations with Clinical Response Clin. Cancer Res., April 1, 2004; 10(7): 2253 - 2264. [Abstract] [Full Text] [PDF] S. S. Farag, I. W. Flinn, R. Modali, T. A. Lehman, D. Young, and J. C. Byrd Fc{gamma}RIIIa and Fc{gamma}RIIa polymorphisms do not predict response to rituximab in B-cell chronic lymphocytic leukemia Blood, February 15, 2004; 103(4): 1472 - 1474. [Abstract] [Full Text] [PDF] W. F. Rosse, P. Hillmen, and A. D. Schreiber Immune-Mediated Hemolytic Anemia Hematology, January 1, 2004; 2004(1): 48 - 62. [Abstract] [Full Text] [PDF] W.-K. Weng and R. Levy Two Immunoglobulin G Fragment C Receptor Polymorphisms Independently Predict Response to Rituximab in Patients With Follicular Lymphoma J. Clin. Oncol., November 1, 2003; 21(21): 3940 - 3947. [Abstract] [Full Text] [PDF] A. W. Morgan, V. H. Keyte, S. J. Babbage, J. I. Robinson, F. Ponchel, J. H. Barrett, B. B. Bhakta, S. J. Bingham, M. H. Buch, P. G. Conaghan, et al. Fc{gamma}RIIIA-158V and rheumatoid arthritis: a confirmation study Rheumatology, April 1, 2003; 42(4): 528 - 533. [Abstract] [Full Text] [PDF] K. E. Sullivan, A. F. Jawad, L. M. Piliero, N. Kim, X. Luan, D. Goldman, and M. Petri Analysis of polymorphisms affecting immune complex handling in systemic lupus erythematosus Rheumatology, March 1, 2003; 42(3): 446 - 452. [Abstract] [Full Text] [PDF] A Milicic, R Misra, S Agrawal, A Aggarwal, M A Brown, and B P Wordsworth The F158V polymorphism in Fc{gamma}RIIIA shows disparate associations with rheumatoid arthritis in two genetically distinct populations Ann Rheum Dis, November 1, 2002; 61(11): 1021 - 1023. [Abstract] [Full Text] [PDF] K Manger, R Repp, M Jansen, M Geisselbrecht, R Wassmuth, N A C Westerdaal, A Pfahlberg, B Manger, J R Kalden, and J G J van de Winkel Fc{gamma} receptor IIa, IIIa, and IIIb polymorphisms in German patients with systemic lupus erythematosus: association with clinical symptoms Ann Rheum Dis, September 1, 2002; 61(9): 786 - 792. [Abstract] [Full Text] [PDF] A. L. Rose, B. E. Smith, and D. G. Maloney Glucocorticoids and rituximab in vitro: synergistic direct antiproliferative and apoptotic effects Blood, August 13, 2002; 100(5): 1765 - 1773. [Abstract] [Full Text] [PDF] R. L. Shields, J. Lai, R. Keck, L. Y. O'Connell, K. Hong, Y. G. Meng, S. H. A. Weikert, and L. G. Presta Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human Fcgamma RIII and Antibody-dependent Cellular Toxicity J. Biol. Chem., July 19, 2002; 277(30): 26733 - 26740. [Abstract] [Full Text] [PDF] G. Cartron, L. Dacheux, G. Salles, P. Solal-Celigny, P. Bardos, P. Colombat, and H. Watier Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor Fcgamma RIIIa gene Blood, February 1, 2002; 99(3): 754 - 758. [Abstract] [Full Text] [PDF] T. A. Trikalinos, F. B. Karassa, and J. P. A. Ioannidis Meta-analysis of the association between low-affinity Fcgamma receptor gene polymorphisms and hematologic and autoimmune diseases Blood, September 1, 2001; 98(5): 1634 - 1636. [Full Text] [PDF] T. L. nbecher, C. B. Foster, S. Zhu, D. Venzon, S. M. Steinberg, K. Wyvill, J. A. Metcalf, S. S. Cohen, J. Kovacs, R. Yarchoan, et al. Variant genotypes of Fcgamma RIIIA influence the development of Kaposi's sarcoma in HIV-infected men Blood, April 1, 2000; 95(7): 2386 - 2390. [Abstract] [Full Text] [PDF] T. Lehrnbecher, C. B. Foster, S. Zhu, S. F. Leitman, L. R. Goldin, K. Huppi, and S. J. Chanock Variant Genotypes of the Low-Affinity Fcgamma Receptors in Two Control Populations and a Review of Low-Affinity Fcgamma Receptor Polymorphisms in Control and Disease Populations Blood, December 15, 1999; 94(12): 4220 - 4232. [Abstract] [Full Text] [PDF] R. L. Shields, A. K. Namenuk, K. Hong, Y. G. Meng, J. Rae, J. Briggs, D. Xie, J. Lai, A. Stadlen, B. Li, et al. High Resolution Mapping of the Binding Site on Human IgG1 for Fcgamma RI, Fcgamma RII, Fcgamma RIII, and FcRn and Design of IgG1 Variants with Improved Binding to the Fcgamma R J. Biol. Chem., February 23, 2001; 276(9): 6591 - 6604. [Abstract] [Full Text] [PDF]

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