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RAPID COMMUNICATION
STAT5A-Deficient Mice Demonstrate a Defect in Granulocyte-Macrophage Colony-Stimulating Factor-Induced Proliferation and Gene Expression
Gerald M. Feldman,
Louis A. Rosenthal,
Xiuwen Liu,
Mark P. Hayes,
Anthony Wynshaw-Boris,
Warren J. Leonard,
Lothar Hennighausen, and
David S. Finbloom
From the Division of Cytokine Biology, Center for Biologics Evaluation and Research, Food and Drug Administration; the Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, NIH; the Laboratory of Genetic Disease Research, National Human Genome Research Institute, NIH; and the Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD.
Responses of cells to cytokines typically involve the activation of a family of latent DNA binding proteins, referred to as signal transducers and activators of transcription (STAT) proteins, which are critical for the expression of early response genes. Of the seven known STAT proteins, STAT5 (originally called mammary gland factor) has been shown to be activated by several cytokines, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5, which are known to play important roles in growth and differentiation of hematopoietic precursors. In this report we have used mice that are deficient in STAT5A (one of two homologues of STAT5) to study the role of STAT5A in GM-CSF stimulation of cells. When bone marrow-derived macrophages were generated by differentiation with macrophage-CSF (M-CSF), exposure of cells from wild-type mice to GM-CSF resulted in a typical pattern of assembly of DNA binding proteins specific for the gamma activation sequence (GAS) element within the  -casein promoter. However, in cells from the STAT5A null mouse one of the shifted bands was absent. Immunoblotting analysis in the null mice showed that lack of STAT5A protein resulted in no alteration in activation of STAT5B by tyrosine phosphorylation. Proliferation experiments revealed that, when exposed to increasing concentrations of GM-CSF, cells derived from the null mice grew considerably more slowly than cells derived from the wild-type mice. Moreover, expression of GM-CSF-dependent genes, CIS and A1, was markedly inhibited in cells derived from null mice as compared with those of wild-type mice. The decreased expression observed with A1, a bcl-2 like gene, may account in part for the suppression of growth in cells from the null mice. These data suggest that the presence of STAT5A during the GM-CSF-induced assembly of STAT5 dimers is critical for the formation of competent transcription factors that are required for both gene expression and cell proliferation.
Blood, Vol. 90 No. 5 (September 1), 1997:
pp. 1768-1776
© 1997 by The American Society of Hematology.
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180(2):
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[Abstract]
[Full Text]
[PDF]
|
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110(8):
2880 - 2888.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
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Z. Yao, Y. Kanno, M. Kerenyi, G. Stephens, L. Durant, W. T. Watford, A. Laurence, G. W. Robinson, E. M. Shevach, R. Moriggl, et al.
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May 15, 2007;
109(10):
4368 - 4375.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Harir, C. Pecquet, M. Kerenyi, K. Sonneck, B. Kovacic, R. Nyga, M. Brevet, I. Dhennin, V. Gouilleux-Gruart, H. Beug, et al.
Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias
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February 15, 2007;
109(4):
1678 - 1686.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
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M. Schmerer, I. Torregroza, A. Pascal, M. Umbhauer, and T. Evans
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November 1, 2006;
108(9):
2989 - 2997.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. A. Nelson, S. R. Walker, W. Li, X. S. Liu, and D. A. Frank
Identification of Human STAT5-dependent Gene Regulatory Elements Based on Interspecies Homology
J. Biol. Chem.,
September 8, 2006;
281(36):
26216 - 26224.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Ye, N. Wolff, L. Li, S. Zhang, and R. L. Ilaria Jr
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June 15, 2006;
107(12):
4917 - 4925.
[Abstract]
[Full Text]
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|
|
|
|
|
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|
Y. Sekine, T. Yamamoto, T. Yumioka, K. Sugiyama, S. Tsuji, K. Oritani, K. Shimoda, M. Minoguchi, A. Yoshimura, and T. Matsuda
Physical and Functional Interactions between STAP-2/BKS and STAT5
J. Biol. Chem.,
March 4, 2005;
280(9):
8188 - 8196.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. A. Nelson, S. R. Walker, J. V. Alvarez, and D. A. Frank
Isolation of Unique STAT5 Targets by Chromatin Immunoprecipitation-based Gene Identification
J. Biol. Chem.,
December 24, 2004;
279(52):
54724 - 54730.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
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11(3):
588 - 598.
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|
|
|
|
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December 15, 2003;
23(24):
8934 - 8945.
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[Full Text]
[PDF]
|
|
|
|
|
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77(23):
12630 - 12638.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
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J. W. Snow, N. Abraham, M. C. Ma, B. G. Herndier, A. W. Pastuszak, and M. A. Goldsmith
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171(10):
5042 - 5050.
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[Full Text]
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|
|
|
|
|
|
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|
|
|
|
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101(8):
2940 - 2954.
[Abstract]
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|
|
|
|
|
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133(1):
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[Abstract]
[Full Text]
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|
|
|
|
|
|
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101(1):
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|
|
|
|
|
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169(2):
714 - 721.
[Abstract]
[Full Text]
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|
|
|
|
|
|
|
N. Ghilardi, J. Li, J.-A. Hongo, S. Yi, A. Gurney, and F. J. de Sauvage
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277(19):
16831 - 16836.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Zeng, Y. Aoki, M. Yoshida, K.-i. Arai, and S. Watanabe
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J. Immunol.,
May 1, 2002;
168(9):
4567 - 4575.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Lehtonen, S. Matikainen, M. Miettinen, and I. Julkunen
Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced STAT5 activation and target-gene expression during human monocyte/macrophage differentiation
J. Leukoc. Biol.,
March 1, 2002;
71(3):
511 - 519.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. D. Bunting, H. L. Bradley, T. S. Hawley, R. Moriggl, B. P. Sorrentino, and J. N. Ihle
Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5
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January 15, 2002;
99(2):
479 - 487.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. W. Snow, N. Abraham, M. C. Ma, N. W. Abbey, B. Herndier, and M. A. Goldsmith
STAT5 promotes multilineage hematolymphoid development in vivo through effects on early hematopoietic progenitor cells
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January 1, 2002;
99(1):
95 - 101.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Dif, E. Saunier, B. Demeneix, P. A. Kelly, and M. Edery
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Endocrinology,
December 1, 2001;
142(12):
5286 - 5293.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Socolovsky, H.-s. Nam, M. D. Fleming, V. H. Haase, C. Brugnara, and H. F. Lodish
Ineffective erythropoiesis in Stat5a-/-5b-/- mice due to decreased survival of early erythroblasts
Blood,
December 1, 2001;
98(12):
3261 - 3273.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Horikawa, H. Kaku, H. Nakajima, H. W. Davey, L. Henninghausen, I. Iwamoto, T. Yasue, A. Kariyone, and K. Takatsu
Essential Role of Stat5 for IL-5-Dependent IgH Switch Recombination in Mouse B Cells
J. Immunol.,
November 1, 2001;
167(9):
5018 - 5026.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Bhattacharya, B. A. Stout, M. E. Bates, P. J. Bertics, and J. S. Malter
Granulocyte Macrophage Colony-Stimulating Factor and Interleukin-5 Activate STAT5 and Induce CIS1 mRNA in Human Peripheral Blood Eosinophils
Am. J. Respir. Cell Mol. Biol.,
March 1, 2001;
24(3):
312 - 316.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Watanabe, R. Zeng, Y. Aoki, T. Itoh, and K.-i. Arai
Initiation of polyoma virus origin-dependent DNA replication through STAT5 activation by human granulocyte-macrophage colony-stimulating factor
Blood,
March 1, 2001;
97(5):
1266 - 1273.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. F. Valledor, M. Comalada, J. Xaus, and A. Celada
The Differential Time-course of Extracellular-regulated Kinase Activity Correlates with the Macrophage Response toward Proliferation or Activation
J. Biol. Chem.,
March 15, 2000;
275(10):
7403 - 7409.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-i. Kagami, H. Nakajima, K. Kumano, K. Suzuki, A. Suto, K. Imada, H. W. Davey, Y. Saito, K. Takatsu, W. J. Leonard, et al.
Both Stat5a and Stat5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue
Blood,
February 15, 2000;
95(4):
1370 - 1377.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kieslinger, I. Woldman, R. Moriggl, J. Hofmann, J.-C. Marine, J. N. Ihle, H. Beug, and T. Decker
Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation
Genes & Dev.,
January 15, 2000;
14(2):
232 - 244.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. C. Ward, I. Touw, and A. Yoshimura
The Jak-Stat pathway in normal and perturbed hematopoiesis
Blood,
January 1, 2000;
95(1):
19 - 29.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Matsumoto, Y. Seki, M. Kubo, S. Ohtsuka, A. Suzuki, I. Hayashi, K. Tsuji, T. Nakahata, M. Okabe, S. Yamada, et al.
Suppression of STAT5 Functions in Liver, Mammary Glands, and T Cells in Cytokine-Inducible SH2-Containing Protein 1 Transgenic Mice
Mol. Cell. Biol.,
September 1, 1999;
19(9):
6396 - 6407.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. P. de Groot, J. A.M. Raaijmakers, J.-W. J. Lammers, R. Jove, and L. Koenderman
STAT5 Activation by BCR-Abl Contributes to Transformation of K562 Leukemia Cells
Blood,
August 1, 1999;
94(3):
1108 - 1112.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Tanaka, K. Kaneko, H. Asao, H. Kasai, Y. Endo, T. Fujita, T. Takeshita, and K. Sugamura
Possible Involvement of a Novel STAM-associated Molecule "AMSH" in Intracellular Signal Transduction Mediated by Cytokines
J. Biol. Chem.,
July 2, 1999;
274(27):
19129 - 19135.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. L. Ilaria Jr, R. G. Hawley, and R. A. Van Etten
Dominant Negative Mutants Implicate STAT5 in Myeloid Cell Proliferation and Neutrophil Differentiation
Blood,
June 15, 1999;
93(12):
4154 - 4166.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ji, R. Guan, S. J. Frank, and J. L. Messina
Insulin Inhibits Growth Hormone Signaling via the Growth Hormone Receptor/JAK2/STAT5B Pathway
J. Biol. Chem.,
May 7, 1999;
274(19):
13434 - 13442.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Nieborowska-Skorska, M. A. Wasik, A. Slupianek, P. Salomoni, T. Kitamura, B. Calabretta, and T. Skorski
Signal Transducer and Activator of Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for Leukemogenesis
J. Exp. Med.,
April 19, 1999;
189(8):
1229 - 1242.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Reed, M. Ikegami, E. R. Cianciolo, W. Lu, P. S. Cho, W. Hull, A. H. Jobe, and J. A. Whitsett
Aerosolized GM-CSF ameliorates pulmonary alveolar proteinosis in GM-CSF-deficient mice
Am J Physiol Lung Cell Mol Physiol,
April 1, 1999;
276(4):
L556 - L563.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N.A. NICOLA, S.E. NICHOLSON, D. METCALF, J.-G. ZHANG, M. BACA, A. FARLEY, T.A. WILLSON, R. STARR, W. ALEXANDER, and D.J. HILTON
Negative Regulation of Cytokine Signaling by the SOCS Proteins
Cold Spring Harb Symp Quant Biol,
January 1, 1999;
64(0):
397 - 404.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. Boucheron, S. Dumon, S. C. R. Santos, R. Moriggl, L. Hennighausen, S. Gisselbrecht, and F. Gouilleux
A Single Amino Acid in the DNA Binding Regions of STAT5A and STAT5B Confers Distinct DNA Binding Specificities
J. Biol. Chem.,
December 18, 1998;
273(51):
33936 - 33941.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Dong, X. Liu, J. P. de Koning, I. P. Touw, L. Henninghausen, A. Larner, and P. M. Grimley
Stimulation of Stat5 by Granulocyte Colony-Stimulating Factor (G-CSF) Is Modulated by Two Distinct Cytoplasmic Regions of the G-CSF Receptor
J. Immunol.,
December 15, 1998;
161(12):
6503 - 6509.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Imada, E. T. Bloom, H. Nakajima, J. A. Horvath-Arcidiacono, G. B. Udy, H. W. Davey, and W. J. Leonard
Stat5b Is Essential for Natural Killer Cell-mediated Proliferation and Cytolytic Activity
J. Exp. Med.,
December 7, 1998;
188(11):
2067 - 2074.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. F. Seymour, C. G. Begley, U. Dirksen, J. J. Presneill, N. A. Nicola, P. E. Moore, O. D. Schoch, P. vanAsperen, B. Roth, S. Burdach, et al.
Attenuated Hematopoietic Response to Granulocyte-Macrophage Colony-Stimulating Factor in Patients With Acquired Pulmonary Alveolar Proteinosis
Blood,
October 15, 1998;
92(8):
2657 - 2667.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Verdier, R. Rabionet, F. Gouilleux, C. Beisenherz-Huss, P. Varlet, O. Muller, P. Mayeux, C. Lacombe, S. Gisselbrecht, and S. Chretien
A Sequence of the CIS Gene Promoter Interacts Preferentially with Two Associated STAT5A Dimers: a Distinct Biochemical Difference between STAT5A and STAT5B
Mol. Cell. Biol.,
October 1, 1998;
18(10):
5852 - 5860.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
Y. Okajima, I. Matsumura, T. Nishiura, K. Hashimoto, H. Yoshida, J. Ishikawa, H. Wakao, A. Yoshimura, Y. Kanakura, Y. Tomiyama, et al.
Insulin-like Growth Factor-I Augments Erythropoietin-induced Proliferation through Enhanced Tyrosine Phosphorylation of STAT5
J. Biol. Chem.,
September 4, 1998;
273(36):
22877 - 22883.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Adachi and R. Alam
The mechanism of IL-5 signal transduction
Am J Physiol Cell Physiol,
September 1, 1998;
275(3):
C623 - C633.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. C. Gregory, N. Jiang, K. Todokoro, J. Crouse, R. E. Pacifici, and D. M. Wojchowski
Erythropoietin Receptor and STAT5-Specific Pathways Promote SKT6 Cell Hemoglobinization
Blood,
August 15, 1998;
92(4):
1104 - 1118.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Matsumura, K. Nakajima, H. Wakao, S. Hattori, K. Hashimoto, H. Sugahara, T. Kato, H. Miyazaki, T. Hirano, and Y. Kanakura
Involvement of Prolonged Ras Activation in Thrombopoietin-Induced Megakaryocytic Differentiation of a Human Factor-Dependent Hematopoietic Cell Line
Mol. Cell. Biol.,
July 1, 1998;
18(7):
4282 - 4290.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. C. Mulloy, T.-S. Migone, T. M. Ross, N. Ton, P. L. Green, W. J. Leonard, and G. Franchini
Human and Simian T-Cell Leukemia Viruses Type 2 (HTLV-2 and STLV-2pan-p) Transform T Cells Independently of Jak/STAT Activation
J. Virol.,
May 1, 1998;
72(5):
4408 - 4412.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. B. Ehret, P. Reichenbach, U. Schindler, C. M. Horvath, S. Fritz, M. Nabholz, and P. Bucher
DNA Binding Specificity of Different STAT Proteins. COMPARISON OF IN VITRO SPECIFICITY WITH NATURAL TARGET SITES
J. Biol. Chem.,
February 23, 2001;
276(9):
6675 - 6688.
[Abstract]
[Full Text]
[PDF]
|
|
|
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