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In Vivo Removal of Malaria Parasites From Red Blood Cells Without Their Destruction in Acute Falciparum Malaria
Brian J. Angus,
Kesinee Chotivanich,
Rachanee Udomsangpetch, and
Nicholas J. White
From the Faculty of Tropical Medicine and Faculty of Science, Department of Pathobiology, Mahidol University, Bangkok, Thailand; and the Center for Tropical Medicine and Infectious Diseases, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford University, Oxford, UK.
During acute falciparum malaria infection, red blood cells (RBC) containing abundant ring-infected erythrocyte surface antigen (Pf 155 or RESA), but no intracellular parasites, are present in the circulation. These RESA-positive parasite negative RBC are not seen in parasite cultures in vitro. This indicates that in acute falciparum malaria there is active removal of intraerythrocytic parasites by a host mechanism in vivo (probably the spleen) without destruction of the parasitized RBC. This may explain the observed disparity between the drop in hematocrit and decrease in parasite count in some hyperparasitemic patients. The fate of these "once-parasitized" RBC in vivo is not known.
Blood, Vol. 90 No. 5 (September 1), 1997:
pp. 2037-2040
© 1997 by The American Society of Hematology.
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