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BCR-ABL Transcripts in Bone Marrow Aspirates of Philadelphia-Negative Essential Thrombocythemia Patients: Clinical Presentation
Dorit Blickstein,
Adina Aviram,
Jacob Luboshitz,
Miron Prokocimer,
Pinhas Stark,
Osnat Bairey,
Jaqueline Sulkes, and
Mati Shaklai
From the Division of Hematology and Epidemiology Unit, Rabin Medical Center, Beilinson Campus, Petah-Tikva, Israel.
One of the diagnostic criteria of essential thrombocythemia (ET) is the absence of the Philadelphia chromosome (Ph-neg). On the molecular level, Ph-neg ET patients may carry BCR-ABL transcript. The natural history of BCR-ABL positive Ph-neg ET patients is undetermined. We examined the BCR-ABL status by reverse transcriptase two-step nested polymerase chain reaction in bone marrow aspirates of 25 Ph-neg ET patients. We found 12 BCR-ABL positive and 13 BCR-ABL negative patients in the study group. The comparison showed that the two groups had similar clinical and laboratory characteristics, except for a significant increased patients' age and decreased polymorphonuclear cell count in the BCR-ABL positive group. During a median follow-up of 20 and 22.5 months for the BCR-ABL negative and positive groups, respectively, there was neither blastic transformation nor unrelated death in both groups. We conclude that it is important to look for BCR-ABL transcript in Ph-neg ET patients and to follow them closely to investigate the nature of this translocation in this group of patients.
Blood, Vol. 90 No. 7 (October 1), 1997:
pp. 2768-2771
© 1997 by The American Society of Hematology.
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