|
|
 Previous Article | Table of Contents | Next Article 
AF6q21, a Novel Partner of the MLL Gene in t(6; 11)(q21; q23), Defines a Forkhead Transcriptional Factor Subfamily
Josette Hillion,
Maryvonne Le Coniat,
Philippe Jonveaux,
Roland Berger, and
O.A. Bernard
From Unité Institut National de la Santé et de la Recherche Médicale (INSERM) U301 and Structure d' Intervention (SD) 401 No. 301 Centre National de la Recherche Scientifique (CNRS), Institut de Génétique Moléculaire, Paris; and Laboratoire de Génétique, Centre Hospitalier Universitaire (CHU), Hôpitaux de Brabois, Vandoeuvre, France.
Fusion genes implicating the MLL gene have been recently demonstrated in various 11q23 chromosomal abnormalities in human hematopoietic malignancies. We analyzed a t(6; 11)(q21; q23) translocation detected in a secondary acute myeloblastic leukemia. This translocation results in fusion of the MLL gene on 11q23 to a previously unknown gene on chromosome 6 that differs from the previously reported MLL partner gene AF6q. The novel gene, named AF6q21, encodes a forkhead (FH) protein with strong similarities to the two FH family members whose genes are already known to be involved in chromosomal translocations of human malignancies, AFX and FKHR. Strikingly, in these translocations the breakpoints are located at the same position within the FH domains. Therefore, AF6q21, AFX, and FKHR could define a new FH subfamily particularly involved in human malignancies.
Blood, Vol. 90 No. 9 (November 1), 1997:
pp. 3714-3719
© 1997 by The American Society of Hematology.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
C. J. Lau, Z. Koty, and J. Nalbantoglu
Differential Response of Glioma Cells to FOXO1-Directed Therapy
Cancer Res.,
July 1, 2009;
69(13):
5433 - 5440.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Huang and D. J. Tindall
Dynamic FoxO transcription factors
J. Cell Sci.,
August 1, 2007;
120(15):
2479 - 2487.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A Glauser and W. Schlegel
The emerging role of FOXO transcription factors in pancreatic {beta} cells
J. Endocrinol.,
May 1, 2007;
193(2):
195 - 207.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Shore, P. C. White, R. C.-Y. Hui, A. Essafi, E. W.-F. Lam, M. Rowe, and P. Brennan
Epstein-Barr Virus Represses the FoxO1 Transcription Factor through Latent Membrane Protein 1 and Latent Membrane Protein 2A
J. Virol.,
November 15, 2006;
80(22):
11191 - 11199.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Sagaert, P. de Paepe, L. Libbrecht, V. Vanhentenrijk, G. Verhoef, J. Thomas, I. Wlodarska, and C. De Wolf-Peeters
Forkhead Box Protein P1 Expression in Mucosa-Associated Lymphoid Tissue Lymphomas Predicts Poor Prognosis and Transformation to Diffuse Large B-Cell Lymphoma
J. Clin. Oncol.,
June 1, 2006;
24(16):
2490 - 2497.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. P. Treon, Z. R. Hunter, A. Aggarwal, E. P. Ewen, S. Masota, C. Lee, D. D. Santos, E. Hatjiharissi, L. Xu, X. Leleu, et al.
Characterization of familial Waldenstrom's macroglobulinemia
Ann. Onc.,
March 1, 2006;
17(3):
488 - 494.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Liu, S. Wang, S. Wei, L. Sun, and X. Feng
Receptor Activator of NF-{kappa}B (RANK) Cytoplasmic Motif, 369PFQEP373, Plays a Predominant Role in Osteoclast Survival in Part by Activating Akt/PKB and Its Downstream Effector AFX/FOXO4
J. Biol. Chem.,
December 30, 2005;
280(52):
43064 - 43072.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Perrot and M. M. Rechler
The Coactivator p300 Directly Acetylates the Forkhead Transcription Factor Foxo1 and Stimulates Foxo1-Induced Transcription
Mol. Endocrinol.,
September 1, 2005;
19(9):
2283 - 2298.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Libura, D. J. Slater, C. A. Felix, and C. Richardson
Therapy-related acute myeloid leukemia-like MLL rearrangements are induced by etoposide in primary human CD34+ cells and remain stable after clonal expansion
Blood,
March 1, 2005;
105(5):
2124 - 2131.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Arimoto-Ishida, M. Ohmichi, S. Mabuchi, T. Takahashi, C. Ohshima, J. Hayakawa, A. Kimura, K. Takahashi, Y. Nishio, M. Sakata, et al.
Inhibition of Phosphorylation of a Forkhead Transcription Factor Sensitizes Human Ovarian Cancer Cells to Cisplatin
Endocrinology,
April 1, 2004;
145(4):
2014 - 2022.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Wang, L. Chen, T. J. Maures, J. Herrington, and C. Carter-Su
SH2-B Is a Positive Regulator of Nerve Growth Factor-mediated Activation of the Akt/Forkhead Pathway in PC12 Cells
J. Biol. Chem.,
January 2, 2004;
279(1):
133 - 141.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. M. T. Burgering and R. H. Medema
Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty
J. Leukoc. Biol.,
June 1, 2003;
73(6):
689 - 701.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Komatsu, T. Watanabe, M. Uchida, M. Mori, K. Kirito, S. Kikuchi, Q. Liu, T. Tauchi, K. Miyazawa, H. Endo, et al.
A Member of Forkhead Transcription Factor FKHRL1 Is a Downstream Effector of STI571-induced Cell Cycle Arrest in BCR-ABL-expressing Cells
J. Biol. Chem.,
February 14, 2003;
278(8):
6411 - 6419.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Zhang and C. Wang
PAX3-FKHR Transformation Increases 26 S Proteasome-dependent Degradation of p27Kip1, a Potential Role for Elevated Skp2 Expression
J. Biol. Chem.,
January 3, 2003;
278(1):
27 - 36.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. W. So and M. L. Cleary
MLL-AFX Requires the Transcriptional Effector Domains of AFX To Transform Myeloid Progenitors and Transdominantly Interfere with Forkhead Protein Function
Mol. Cell. Biol.,
September 15, 2002;
22(18):
6542 - 6552.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Lin, C. T. Miller, J. I. Contreras, M. S. Prescott, S. L. Dagenais, R. Wu, J. Yee, M. B. Orringer, D. E. Misek, S. M. Hanash, et al.
The Hepatocyte Nuclear Factor 3 {alpha} Gene, HNF3{alpha} (FOXA1), on Chromosome Band 14q13 Is Amplified and Overexpressed in Esophageal and Lung Adenocarcinomas
Cancer Res.,
September 15, 2002;
62(18):
5273 - 5279.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Furukawa-Hibi, K. Yoshida-Araki, T. Ohta, K. Ikeda, and N. Motoyama
FOXO Forkhead Transcription Factors Induce G2-M Checkpoint in Response to Oxidative Stress
J. Biol. Chem.,
July 19, 2002;
277(30):
26729 - 26732.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. H. Banham, N. Beasley, E. Campo, P. L. Fernandez, C. Fidler, K. Gatter, M. Jones, D. Y. Mason, J. E. Prime, P. Trougouboff, et al.
The FOXP1 Winged Helix Transcription Factor Is a Novel Candidate Tumor Suppressor Gene on Chromosome 3p
Cancer Res.,
December 1, 2001;
61(24):
8820 - 8829.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. N. Finegold, M. A. Kimak, E. C. Lawrence, K. L. Levinson, E. M. Cherniske, B. R. Pober, J. W. Dunlap, and R. E. Ferrell
Truncating mutations in FOXC2 cause multiple lymphedema syndromes
Hum. Mol. Genet.,
May 1, 2001;
10(11):
1185 - 1189.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. W. Johnstone, M. Gerber, T. Landewe, A. Tollefson, W. S. Wold, and A. Shilatifard
Functional Analysis of the Leukemia Protein ELL: Evidence for a Role in the Regulation of Cell Growth and Survival
Mol. Cell. Biol.,
March 1, 2001;
21(5):
1672 - 1681.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
D. J. Price, T. Miralem, S. Jiang, R. Steinberg, and H. Avraham
Role of Vascular Endothelial Growth Factor in the Stimulation of Cellular Invasion and Signaling of Breast Cancer Cells
Cell Growth Differ.,
March 1, 2001;
12(3):
129 - 135.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. Jackson, P. Carrara, V. Duke, P. Sinclair, M. Papaioannou, C. J. Harrison, and L. Foroni
Deletion of 6q16-q21 in Human Lymphoid Malignancies: A Mapping and Deletion Analysis
Cancer Res.,
June 1, 2000;
60(11):
2775 - 2779.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Tsao, X. Zhang, K. Fowlkes, and F. G. Haluska
Relative Reciprocity of NRAS and PTEN/MMAC1 Alterations in Cutaneous Melanoma Cell Lines
Cancer Res.,
April 1, 2000;
60(7):
1800 - 1804.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
Y. Cao and C. Wang
The COOH-terminal Transactivation Domain Plays a Key Role in Regulating the in Vitro and in Vivo Function of Pax3 Homeodomain
J. Biol. Chem.,
March 24, 2000;
275(13):
9854 - 9862.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Tomizawa, A. Kumar, V. Perrot, J. Nakae, D. Accili, and M. M. Rechler
Insulin Inhibits the Activation of Transcription by a C-terminal Fragment of the Forkhead Transcription Factor FKHR. A MECHANISM FOR INSULIN INHIBITION OF INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-1 TRANSCRIPTION
J. Biol. Chem.,
March 15, 2000;
275(10):
7289 - 7295.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. R. Datta, A. Brunet, and M. E. Greenberg
Cellular survival: a play in three Akts
Genes & Dev.,
November 15, 1999;
13(22):
2905 - 2927.
[Full Text]
|
|
|
|
|
|
|
H. Takaishi, H. Konishi, H. Matsuzaki, Y. Ono, Y. Shirai, N. Saito, T. Kitamura, W. Ogawa, M. Kasuga, U. Kikkawa, et al.
Regulation of nuclear translocation of Forkhead transcription factor AFX by protein kinase B
PNAS,
October 12, 1999;
96(21):
11836 - 11841.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. T. Adler, R. Chinery, D. Y. Wu, S. J. Kussick, J. M. Payne, A. J. Fornace Jr., and D. C. Tkachuk
Leukemic HRX Fusion Proteins Inhibit GADD34-Induced Apoptosis and Associate with the GADD34 and hSNF5/INI1 Proteins
Mol. Cell. Biol.,
October 1, 1999;
19(10):
7050 - 7060.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Taki, H. Ohnishi, K. Shinohara, M. Sako, F. Bessho, M. Yanagisawa, and Y. Hayashi
AF17q25, a Putative Septin Family Gene, Fuses the MLL Gene in Acute Myeloid Leukemia with t(11;17)(q23;q25)
Cancer Res.,
September 1, 1999;
59(17):
4261 - 4265.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. H. Biggs III, J. Meisenhelder, T. Hunter, W. K. Cavenee, and K. C. Arden
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
PNAS,
June 22, 1999;
96(13):
7421 - 7426.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Rena, S. Guo, S. C. Cichy, T. G. Unterman, and P. Cohen
Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B
J. Biol. Chem.,
June 11, 1999;
274(24):
17179 - 17183.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Guo, G. Rena, S. Cichy, X. He, P. Cohen, and T. Unterman
Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence
J. Biol. Chem.,
June 11, 1999;
274(24):
17184 - 17192.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Osaka, J. D. Rowley, and N. J. Zeleznik-Le
MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)
PNAS,
May 25, 1999;
96(11):
6428 - 6433.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. L. Strissel, R. Strick, J. D. Rowley, and N. J. Zeleznik-Le
An In Vivo Topoisomerase II Cleavage Site and a DNase I Hypersensitive Site Colocalize Near Exon 9 in the MLL Breakpoint Cluster Region
Blood,
November 15, 1998;
92(10):
3793 - 3803.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W.-H. Zheng, S. Kar, and R. Quirion
Insulin-like Growth Factor-1-induced Phosphorylation of the Forkhead Family Transcription Factor FKHRL1 Is Mediated by Akt Kinase in PC12 Cells
J. Biol. Chem.,
December 8, 2000;
275(50):
39152 - 39158.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Tanaka, K. Kirito, Y. Kashii, M. Uchida, T. Watanabe, H. Endo, T. Endoh, K.-i. Sawada, K. Ozawa, and N. Komatsu
Forkhead Family Transcription Factor FKHRL1 Is Expressed in Human Megakaryocytes. REGULATION OF CELL CYCLING AS A DOWNSTREAM MOLECULE OF THROMBOPOIETIN SIGNALING
J. Biol. Chem.,
April 27, 2001;
276(18):
15082 - 15089.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Brodbeck, M. M. Hill, and B. A. Hemmings
Two Splice Variants of Protein Kinase Bgamma Have Different Regulatory Capacity Depending on the Presence or Absence of the Regulatory Phosphorylation Site Serine 472 in the Carboxyl-terminal Hydrophobic Domain
J. Biol. Chem.,
July 27, 2001;
276(31):
29550 - 29558.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. J. Kourlas, M. P. Strout, B. Becknell, M. L. Veronese, C. M. Croce, K. S. Theil, R. Krahe, T. Ruutu, S. Knuutila, C. D. Bloomfield, et al.
Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: Evidence for its fusion with MLL in acute myeloid leukemia
PNAS,
February 29, 2000;
97(5):
2145 - 2150.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
