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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kim, C. H. Articles by Broxmeyer, H. E. Search for Related Content PubMed PubMed Citation Articles by Kim, C. H. Articles by Broxmeyer, H. E. Related Collections Hematopoiesis and Stem Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  In Vitro Behavior of Hematopoietic Progenitor Cells Under the Influence of Chemoattractants: Stromal Cell-Derived Factor-1, Steel Factor, and the Bone Marrow Environment Chang H. Kim and Hal E. Broxmeyer From the Departments of Microbiology/Immunology, Medicine and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis; and the Walther Cancer Institute, Indianapolis, IN. How multiple chemoattractants cooperate in directing the migration of hematopoietic progenitor cells (HPC) for homing and peripheral blood mobilization has not yet been established. We report here the behavior of HPC under the influence of two different chemoattractants, stromal cell-derived factor (SDF)-1 and steel factor (SLF), and the chemotactic nature of the bone marrow (BM) environment using a two-chamber in vitro migration system. Various formulae were adopted to quantitate these effects. Based on these quantitations, SDF-1 showed only chemotactic activity, while SLF showed both chemotactic and chemokinetic activities on factor-dependent MO7e cells. SLF, like SDF-1, attracted human HPC from a population of CD34+ cells and induced actin polymerization in MO7e cells. SLF and SDF-1 cooperated in attracting MO7e cells, as well as cord blood (CB) and BM CD34+ cells. A negative concentration gradient of SLF and SDF-1, formed by the presence of chemoattractants in the upper chamber, showed potent inhibitory effects on MO7e cell migration induced by either of these chemoattractants in the lower chamber, and SDF-1 and SLF were synergistic in mobilizing cells to the lower chamber from this negative chemoattractant gradient. Plasma obtained from BM aspirates, but not CB or peripheral blood, showed strong chemotactic effects on BM and CB CD34+ cells, and an inhibitory effect in a negative gradient on SDF-1-dependent CD34+ cell migration. These in vitro migration experiments suggest that chemoattractants such as SDF-1 and SLF with other unidentified BM chemoattractants may be involved cooperatively in the migration of HPC to the BM and in preventing spontaneous mobilization of HPC out of the BM. Blood, Vol. 91 No. 1 (January 1), 1998: pp. 100-110 © 1998 by The American Society of Hematology. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. K. Kim, H.-N. Pak, J. H. Park, K. J. Ko, J. S. Lee, J. I. Choi, D. H. Choi, and Y.-H. Kim Clinical and serological predictors for the recurrence of atrial fibrillation after electrical cardioversion Europace, December 1, 2009; 11(12): 1632 - 1638. [Abstract] [Full Text] [PDF] S. K. Kim, H.-N. Pak, J. H. Park, J. I. Choi, M.-H. Nam, Y. Jo, and Y.-H. Kim Non-ischaemic titrated cardiac injury caused by radiofrequency catheter ablation of atrial fibrillation mobilizes CD34-positive mononuclear cells by non-stromal cell-derived factor-1{alpha} mechanism Europace, August 1, 2009; 11(8): 1024 - 1031. [Abstract] [Full Text] [PDF] J. Grassinger, D. N. Haylock, M. J. Storan, G. O. Haines, B. Williams, G. A. Whitty, A. R. Vinson, C. L. Be, S. Li, E. S. 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[Abstract] [Full Text] [PDF] A. Foudi, P. Jarrier, Y. Zhang, M. Wittner, J.-F. Geay, Y. Lecluse, T. Nagasawa, W. Vainchenker, and F. Louache Reduced retention of radioprotective hematopoietic cells within the bone marrow microenvironment in CXCR4-/- chimeric mice Blood, March 15, 2006; 107(6): 2243 - 2251. [Abstract] [Full Text] [PDF] M. Rosu-Myles, E. Stewart, J. Trowbridge, C. Y. Ito, P. Zandstra, and M. Bhatia A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte growth factor/c-met axis J. Cell Sci., October 1, 2005; 118(19): 4343 - 4352. [Abstract] [Full Text] [PDF] Y. J. Woo, T. J. Grand, M. F. Berry, P. Atluri, M. A. Moise, V. M. Hsu, J. Cohen, O. Fisher, J. Burdick, M. Taylor, et al. Stromal cell-derived factor and granulocyte-monocyte colony-stimulating factor form a combined neovasculogenic therapy for ischemic cardiomyopathy J. Thorac. Cardiovasc. Surg., August 1, 2005; 130(2): 321 - 329. [Abstract] [Full Text] [PDF] E. Dalakas, P. N. Newsome, D. J. Harrison, and J. N. Plevris Hematopoietic stem cell trafficking in liver injury FASEB J, August 1, 2005; 19(10): 1225 - 1231. [Abstract] [Full Text] [PDF] S. Basu and H. E. Broxmeyer Transforming growth factor-{beta}1 modulates responses of CD34+ cord blood cells to stromal cell-derived factor-1/CXCL12 Blood, July 15, 2005; 106(2): 485 - 493. [Abstract] [Full Text] [PDF] M. Xu, E. Bruno, J. Chao, S. Huang, G. Finazzi, S. M. Fruchtman, U. Popat, J. T. Prchal, G. Barosi, R. Hoffman, et al. Constitutive mobilization of CD34+ cells into the peripheral blood in idiopathic myelofibrosis may be due to the action of a number of proteases Blood, June 1, 2005; 105(11): 4508 - 4515. [Abstract] [Full Text] [PDF] H. E. Broxmeyer, C. M. Orschell, D. W. Clapp, G. Hangoc, S. Cooper, P. A. Plett, W. C. Liles, X. Li, B. Graham-Evans, T. B. Campbell, et al. Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist J. Exp. Med., April 18, 2005; 201(8): 1307 - 1318. [Abstract] [Full Text] [PDF] S. Fukuda, H. E. Broxmeyer, and L. M. Pelus Flt3 ligand and the Flt3 receptor regulate hematopoietic cell migration by modulating the SDF-1{alpha}(CXCL12)/CXCR4 axis Blood, April 15, 2005; 105(8): 3117 - 3126. [Abstract] [Full Text] [PDF] J.-F. Geay, D. Buet, Y. Zhang, A. Foudi, P. Jarrier, M. Berthebaud, A. G. Turhan, W. Vainchenker, and F. Louache p210BCR-ABL inhibits SDF-1 Chemotactic Response via Alteration of CXCR4 Signaling and Down-regulation of CXCR4 Expression Cancer Res., April 1, 2005; 65(7): 2676 - 2683. [Abstract] [Full Text] [PDF] H. B. Kwak, S. W. Lee, H. M. Jin, H. Ha, S. H. Lee, S. Takeshita, S. Tanaka, H.-M. Kim, H.-H. Kim, and Z. H. Lee Monokine induced by interferon-{gamma} is induced by receptor activator of nuclear factor {kappa}B ligand and is involved in osteoclast adhesion and migration Blood, April 1, 2005; 105(7): 2963 - 2969. [Abstract] [Full Text] [PDF] I. Kryczek, A. Lange, P. Mottram, X. Alvarez, P. Cheng, M. Hogan, L. Moons, S. Wei, L. Zou, V. Machelon, et al. CXCL12 and Vascular Endothelial Growth Factor Synergistically Induce Neoangiogenesis in Human Ovarian Cancers Cancer Res., January 15, 2005; 65(2): 465 - 472. [Abstract] [Full Text] [PDF] S. Okabe, S. Fukuda, Y.-J. Kim, M. Niki, L. M. Pelus, K. Ohyashiki, P. P. Pandolfi, and H. E. Broxmeyer Stromal cell-derived factor-1{alpha}/CXCL12-induced chemotaxis of T cells involves activation of the RasGAP-associated docking protein p62Dok-1 Blood, January 15, 2005; 105(2): 474 - 480. [Abstract] [Full Text] [PDF] B. Giebel, D. Corbeil, J. Beckmann, J. Hohn, D. Freund, K. Giesen, J. Fischer, G. Kogler, and P. Wernet Segregation of lipid raft markers including CD133 in polarized human hematopoietic stem and progenitor cells Blood, October 15, 2004; 104(8): 2332 - 2338. [Abstract] [Full Text] [PDF] E. Monfardini, V. Van Merris, M. Paape, L. Duchateau, and C. Burvenich L-Selectin and Chemotaxis Throughout Bone Marrow Granulocyte Maturation in the Bovine J Dairy Sci, October 1, 2004; 87(10): 3350 - 3357. [Abstract] [Full Text] [PDF] K. W. Christopherson II, G. Hangoc, C. R. Mantel, and H. E. Broxmeyer Modulation of Hematopoietic Stem Cell Homing and Engraftment by CD26 Science, August 13, 2004; 305(5686): 1000 - 1003. [Abstract] [Full Text] [PDF] E. J. C. Rombouts, B. Pavic, B. Lowenberg, and R. E. Ploemacher Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia Blood, July 15, 2004; 104(2): 550 - 557. [Abstract] [Full Text] [PDF] B. T. Suratt, J. M. Petty, S. K. Young, K. C. Malcolm, J. G. Lieber, J. A. Nick, J.-A. Gonzalo, P. M. Henson, and G. S. Worthen Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis Blood, July 15, 2004; 104(2): 565 - 571. [Abstract] [Full Text] [PDF] T. Kimura, A. M. Boehmler, G. Seitz, S. Kuci, T. Wiesner, V. Brinkmann, L. Kanz, and R. Mohle The sphingosine 1-phosphate receptor agonist FTY720 supports CXCR4-dependent migration and bone marrow homing of human CD34+ progenitor cells Blood, June 15, 2004; 103(12): 4478 - 4486. [Abstract] [Full Text] [PDF] C. A. Evans, R. Tonge, D. Blinco, A. Pierce, J. Shaw, Y. Lu, H. G. Hamzah, A. Gray, C. P. Downes, S. J. Gaskell, et al. Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility Blood, May 15, 2004; 103(10): 3751 - 3759. [Abstract] [Full Text] [PDF] Y. Ueda, K. Yang, S. J. Foster, M. Kondo, and G. Kelsoe Inflammation Controls B Lymphopoiesis by Regulating Chemokine CXCL12 Expression J. Exp. Med., January 5, 2004; 199(1): 47 - 58. [Abstract] [Full Text] [PDF] L. M. Pelus, H. Bian, A. G. King, and S. Fukuda Neutrophil-derived MMP-9 mediates synergistic mobilization of hematopoietic stem and progenitor cells by the combination of G-CSF and the chemokines GRO{beta}/CXCL2 and GRO{beta}T /CXCL2{Delta}4 Blood, January 1, 2004; 103(1): 110 - 119. [Abstract] [Full Text] [PDF] A. G. Kayali, K. Van Gunst, I. L. Campbell, A. Stotland, M. Kritzik, G. Liu, M. Flodstrom-Tullberg, Y.-Q. Zhang, and N. Sarvetnick The stromal cell-derived factor-1{alpha}/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas J. Cell Biol., November 24, 2003; 163(4): 859 - 869. [Abstract] [Full Text] [PDF] S. Villalba, O. Salvucci, Y. Aoki, M. D. L. L. Sierra, G. Gupta, D. Davis, K. Wyvill, R. Little, R. Yarchoan, and G. Tosato Serum inactivation contributes to the failure of stromal-derived factor-1 to block HIV-I infection in vivo J. Leukoc. Biol., November 1, 2003; 74(5): 880 - 888. [Abstract] [Full Text] [PDF] W. C. Liles, H. E. Broxmeyer, E. Rodger, B. Wood, K. Hubel, S. Cooper, G. Hangoc, G. J. Bridger, G. W. Henson, G. Calandra, et al. Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist Blood, October 15, 2003; 102(8): 2728 - 2730. [Abstract] [Full Text] [PDF] A. D. Whetton, Y. Lu, A. Pierce, L. Carney, and E. Spooncer Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1 Blood, October 15, 2003; 102(8): 2798 - 2802. [Abstract] [Full Text] [PDF] N. Wright, T. L. de Lera, C. Garcia-Moruja, R. Lillo, F. Garcia-Sanchez, A. Caruz, and J. Teixido Transforming growth factor-{beta}1 down-regulates expression of chemokine stromal cell-derived factor-1: functional consequences in cell migration and adhesion Blood, September 15, 2003; 102(6): 1978 - 1984. [Abstract] [Full Text] [PDF] J. D. van Buul, C. Voermans, J. van Gelderen, E. C. Anthony, C. E. van der Schoot, and P. L. Hordijk Leukocyte-Endothelium Interaction Promotes SDF-1-dependent Polarization of CXCR4 J. Biol. Chem., August 8, 2003; 278(32): 30302 - 30310. [Abstract] [Full Text] [PDF] K. W. Christopherson II, S. Cooper, and H. E. Broxmeyer Cell surface peptidase CD26/DPPIV mediates G-CSF mobilization of mouse progenitor cells Blood, June 15, 2003; 101(12): 4680 - 4686. [Abstract] [Full Text] [PDF] T. Papayannopoulou, G. V. Priestley, H. Bonig, and B. Nakamoto The role of G-protein signaling in hematopoietic stem/progenitor cell mobilization Blood, June 15, 2003; 101(12): 4739 - 4747. [Abstract] [Full Text] [PDF] H. E. Broxmeyer, S. Cooper, L. Kohli, G. Hangoc, Y. Lee, C. Mantel, D. W. Clapp, and C. H. Kim Transgenic Expression of Stromal Cell-Derived Factor-1/CXC Chemokine Ligand 12 Enhances Myeloid Progenitor Cell Survival/Antiapoptosis In Vitro in Response to Growth Factor Withdrawal and Enhances Myelopoiesis In Vivo J. Immunol., January 1, 2003; 170(1): 421 - 429. [Abstract] [Full Text] [PDF] A. D. Cristillo, M. J. Macri, and B. E. Bierer Differential chemokine expression profiles in human peripheral blood T lymphocytes: dependence on T-cell coreceptor and calcineurin signaling Blood, January 1, 2003; 101(1): 216 - 225. [Abstract] [Full Text] [PDF] K. W. Christopherson II, G. Hangoc, and H. E. Broxmeyer Cell Surface Peptidase CD26/Dipeptidylpeptidase IV Regulates CXCL12/Stromal Cell-Derived Factor-1{alpha}-Mediated Chemotaxis of Human Cord Blood CD34+ Progenitor Cells J. Immunol., December 15, 2002; 169(12): 7000 - 7008. [Abstract] [Full Text] [PDF] T. Kijima, G. Maulik, P. C. Ma, E. V. Tibaldi, R. E. Turner, B. Rollins, M. Sattler, B. E. Johnson, and R. Salgia Regulation of Cellular Proliferation, Cytoskeletal Function, and Signal Transduction through CXCR4 and c-Kit in Small Cell Lung Cancer Cells Cancer Res., November 1, 2002; 62(21): 6304 - 6311. [Abstract] [Full Text] [PDF] G. Bug, T. Rossmanith, R. Henschler, L.A. Kunz-Schughart, B. Schroder, M. Kampfmann, M. Kreutz, D. Hoelzer, and O. G. Ottmann Rho family small GTPases control migration of hematopoietic progenitor cells into multicellular spheroids of bone marrow stroma cells J. Leukoc. Biol., October 1, 2002; 72(4): 837 - 845. [Abstract] [Full Text] [PDF] A. Ptasznik, E. Urbanowska, S. Chinta, M. A. Costa, B. A. Katz, M. A. Stanislaus, G. Demir, D. Linnekin, Z. K. Pan, and A. M. Gewirtz Crosstalk Between BCR/ABL Oncoprotein and CXCR4 Signaling through a Src Family Kinase in Human Leukemia Cells J. Exp. Med., September 2, 2002; 196(5): 667 - 678. [Abstract] [Full Text] [PDF] T. Netelenbos, S. Zuijderduijn, J. van den Born, F. L. Kessler, S. Zweegman, P. C. Huijgens, and A. M. Drager Proteoglycans guide SDF-1-induced migration of hematopoietic progenitor cells J. Leukoc. Biol., August 1, 2002; 72(2): 353 - 362. [Abstract] [Full Text] [PDF] Y. Lee, A. Gotoh, H.-J. Kwon, M. You, L. Kohli, C. Mantel, S. Cooper, G. Hangoc, K. Miyazawa, K. Ohyashiki, et al. Enhancement of intracellular signaling associated with hematopoietic progenitor cell survival in response to SDF-1/CXCL12 in synergy with other cytokines Blood, May 29, 2002; 99(12): 4307 - 4317. [Abstract] [Full Text] [PDF] I. B. Mazo, E. J. Quackenbush, J. B. Lowe, and U. H. von Andrian Total body irradiation causes profound changes in endothelial traffic molecules for hematopoietic progenitor cell recruitment to bone marrow Blood, May 13, 2002; 99(11): 4182 - 4191. [Abstract] [Full Text] [PDF] S. Ueda, M. Mizuki, H. Ikeda, T. Tsujimura, I. Matsumura, K. Nakano, H. Daino, Z.-i. Honda, J. Sonoyama, H. Shibayama, et al. Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis: contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration Blood, May 1, 2002; 99(9): 3342 - 3349. [Abstract] [Full Text] [PDF] O. Salvucci, L. Yao, S. Villalba, A. Sajewicz, S. Pittaluga, and G. Tosato Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1 Blood, April 15, 2002; 99(8): 2703 - 2711. [Abstract] [Full Text] [PDF] A. D. CRISTILLO, H. C. HIGHBARGER, R. L. DEWAR, D. S. DIMITROV, H. GOLDING, and B. E. BIERER Up-regulation of HIV coreceptor CXCR4 expression in human T lymphocytes is mediated in part by a cAMP-responsive element FASEB J, March 1, 2002; 16(3): 354 - 364. [Abstract] [Full Text] [PDF] J.-J. Lataillade, D. Clay, P. Bourin, F. Herodin, C. Dupuy, C. Jasmin, and M.-C. Le Bousse-Kerdiles Stromal cell-derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G0/G1 transition in CD34+ cells: evidence for an autocrine/paracrine mechanism Blood, February 15, 2002; 99(4): 1117 - 1129. [Abstract] [Full Text] [PDF] J. D. van Buul, C. Voermans, V. van den Berg, E. C. Anthony, F. P. J. Mul, S. van Wetering, C. E. van der Schoot, and P. L. Hordijk Migration of Human Hematopoietic Progenitor Cells Across Bone Marrow Endothelium Is Regulated by Vascular Endothelial Cadherin J. Immunol., January 15, 2002; 168(2): 588 - 596. [Abstract] [Full Text] [PDF] K. Balabanian, A. Foussat, L. Bouchet-Delbos, J. Couderc, R. Krzysiek, A. Amara, F. Baleux, A. Portier, P. Galanaud, and D. Emilie Interleukin-10 modulates the sensitivity of peritoneal B lymphocytes to chemokines with opposite effects on stromal cell-derived factor-1 and B-lymphocyte chemoattractant Blood, January 15, 2002; 99(2): 427 - 436. [Abstract] [Full Text] [PDF] T. Jinquan, L. Anting, H. H. Jacobi, C. Glue, C. Jing, L. P. Ryder, H. O. Madsen, A. Svejgaard, P. S. Skov, H.-J. Malling, et al. CXCR3 Expression on CD34+ Hemopoietic Progenitors Induced by Granulocyte-Macrophage Colony-Stimulating Factor: II. Signaling Pathways Involved J. Immunol., October 15, 2001; 167(8): 4405 - 4413. [Abstract] [Full Text] [PDF] B. Dubois, C. Massacrier, and C. Caux Selective attraction of naive and memory B cells by dendritic cells J. Leukoc. Biol., October 1, 2001; 70(4): 633 - 641. [Abstract] [Full Text] [PDF] K. Hattori, B. Heissig, K. Tashiro, T. Honjo, M. Tateno, J.-H. Shieh, N. R. Hackett, M. S. Quitoriano, R. G. Crystal, S. Rafii, et al. Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells Blood, June 1, 2001; 97(11): 3354 - 3360. [Abstract] [Full Text] [PDF] F. Bautz, C. Denzlinger, L. Kanz, and R. Mohle Chemotaxis and transendothelial migration of CD34+ hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1 Blood, June 1, 2001; 97(11): 3433 - 3440. [Abstract] [Full Text] [PDF] J. R. Chan, S. J. Hyduk, and M. I. Cybulsky Chemoattractants Induce a Rapid and Transient Upregulation of Monocyte {alpha}4 Integrin Affinity for Vascular Cell Adhesion Molecule 1 Which Mediates Arrest: An Early Step in the Process of Emigration J. Exp. Med., May 21, 2001; 193(10): 1149 - 1158. [Abstract] [Full Text] [PDF] Y. Nagata, M. Oda, H. Nakata, Y. Shozaki, T. Kozasa, and K. Todokoro A novel regulator of G-protein signaling bearing GAP activity for G{alpha}i and G{alpha}q in megakaryocytes Blood, May 15, 2001; 97(10): 3051 - 3060. [Abstract] [Full Text] [PDF] O. Kollet, A. Spiegel, A. Peled, I. Petit, T. Byk, R. Hershkoviz, E. Guetta, G. Barkai, A. Nagler, and T. Lapidot Rapid and efficient homing of human CD34+CD38{-}/lowCXCR4+ stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2mnull mice Blood, May 15, 2001; 97(10): 3283 - 3291. [Abstract] [Full Text] [PDF] E. R. Fedyk, D. Jones, H. O. D. Critchley, R. P. Phipps, T. M. Blieden, and T. A. Springer Expression of Stromal-Derived Factor-1 Is Decreased by IL-1 and TNF and in Dermal Wound Healing J. Immunol., May 1, 2001; 166(9): 5749 - 5754. [Abstract] [Full Text] [PDF] R. Kapur, R. Cooper, L. Zhang, and D. A. Williams Cross-talk between {alpha}4{beta}1/{alpha}5{beta}1 and c-Kit results in opposing effect on growth and survival of hematopoietic cells via the activation of focal adhesion kinase, mitogen-activated protein kinase, and Akt signaling pathways Blood, April 1, 2001; 97(7): 1975 - 1981. [Abstract] [Full Text] [PDF] C. Voermans, M. L. K. Kooi, S. Rodenhuis, H. van der Lelie, C. E. van der Schoot, and W. R. Gerritsen In vitro migratory capacity of CD34+ cells is related to hematopoietic recovery after autologous stem cell transplantation Blood, February 1, 2001; 97(3): 799 - 804. [Abstract] [Full Text] [PDF] F. Sanz-Rodriguez, A. Hidalgo, and J. Teixido Chemokine stromal cell-derived factor-1{alpha} modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1 Blood, January 15, 2001; 97(2): 346 - 351. [Abstract] [Full Text] [PDF] H. Dorge, T. Neumann, M. Behrends, A. Skyschally, R. Schulz, C. Kasper, R. Erbel, and G. Heusch Perfusion-contraction mismatch with coronary microvascular obstruction: role of inflammation Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H2587 - H2592. [Abstract] [Full Text] [PDF] S. Yayoshi-Yamamoto, I. Taniuchi, and T. Watanabe FRL, a Novel Formin-Related Protein, Binds to Rac and Regulates Cell Motility and Survival of Macrophages Mol. Cell. Biol., September 15, 2000; 20(18): 6872 - 6881. [Abstract] [Full Text] M. Brandes, D. F. Legler, B. Spoerri, P. Schaerli, and B. Moser Activation-dependent modulation of B lymphocyte migration to chemokines Int. Immunol., September 1, 2000; 12(9): 1285 - 1292. [Abstract] [Full Text] [PDF] T. Jinquan, S. Quan, H. H. Jacobi, C. Jing, A. Millner, B. Jensen, H. O. Madsen, L. P. Ryder, A. Svejgaard, H.-J. Malling, et al. CXC chemokine receptor 3 expression on CD34+ hematopoietic progenitors from human cord blood induced by granulocyte-macrophage colony-stimulating factor: chemotaxis and adhesion induced by its ligands, interferon gamma -inducible protein 10 and monokine induced by interferon gamma Blood, August 15, 2000; 96(4): 1230 - 1238. [Abstract] [Full Text] [PDF] N. Yanai, N. Matsui, T. Furusawa, T. Okubo, and M. Obinata Sphingosine-1-phosphate and lysophosphatidic acid trigger invasion of primitive hematopoietic cells into stromal cell layers Blood, July 1, 2000; 96(1): 139 - 144. [Abstract] [Full Text] [PDF] H. Tagaya, T. Kunisada, H. Yamazaki, T. Yamane, T. Tokuhisa, E. F. Wagner, T. Sudo, L. D. Shultz, and S.-I. Hayashi Intramedullary and extramedullary B lymphopoiesis in osteopetrotic mice Blood, June 1, 2000; 95(11): 3363 - 3370. [Abstract] [Full Text] [PDF] J.-F. Wang, I.-W. Park, and J. E. Groopman Stromal cell-derived factor-1alpha stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C Blood, April 15, 2000; 95(8): 2505 - 2513. [Abstract] [Full Text] [PDF] J.-J. Lataillade, D. Clay, C. Dupuy, S. Rigal, C. Jasmin, P. Bourin, and M.-C. L. Bousse-Kerdiles Chemokine SDF-1 enhances circulating CD34+ cell proliferation in synergy with cytokines: possible role in progenitor survival Blood, February 1, 2000; 95(3): 756 - 768. [Abstract] [Full Text] [PDF] K. Hodohara, N. Fujii, N. Yamamoto, and K. Kaushansky Stromal cell-derived factor-1 (SDF-1) acts together with thrombopoietin to enhance the development of megakaryocytic progenitor cells (CFU-MK) Blood, February 1, 2000; 95(3): 769 - 775. [Abstract] [Full Text] [PDF] A.-S. Charbonnier, N. Kohrgruber, E. Kriehuber, G. Stingl, A. Rot, and D. Maurer Macrophage Inflammatory Protein 3{alpha} Is Involved in the Constitutive Trafficking of Epidermal Langerhans Cells J. Exp. Med., December 20, 1999; 190(12): 1755 - 1768. [Abstract] [Full Text] [PDF] A. J. Naiyer, D.-Y. Jo, J. Ahn, R. Mohle, M. Peichev, G. Lam, R. L. Silverstein, M. A.S. Moore, and S. Rafii Stromal Derived Factor-1-Induced Chemokinesis of Cord Blood CD34+ Cells (Long-Term Culture-Initiating Cells) Through Endothelial Cells Is Mediated by E-Selectin Blood, December 15, 1999; 94(12): 4011 - 4019. [Abstract] [Full Text] [PDF] R. Salgia, E. Quackenbush, J. Lin, N. Souchkova, M. Sattler, D. S. Ewaniuk, K. M. Klucher, G. Q. Daley, S. K. Kraeft, R. Sackstein, et al. The BCR/ABL Oncogene Alters the Chemotactic Response to Stromal-Derived Factor-1alpha Blood, December 15, 1999; 94(12): 4233 - 4246. [Abstract] [Full Text] [PDF] M. Honczarenko, R. S. Douglas, C. Mathias, B. Lee, M. Z. Ratajczak, and L. E. Silberstein SDF-1 Responsiveness Does Not Correlate With CXCR4 Expression Levels of Developing Human Bone Marrow B Cells Blood, November 1, 1999; 94(9): 2990 - 2998. [Abstract] [Full Text] [PDF] T. Ishii, M. Nishihara, F. Ma, Y. Ebihara, K. Tsuji, S. Asano, T. Nakahata, and T. Maekawa Expression of Stromal Cell-Derived Factor-1/Pre-B Cell Growth-Stimulating Factor Receptor, CXC Chemokine Receptor 4, on CD34+ Human Bone Marrow Cells Is a Phenotypic Alteration for Committed Lymphoid Progenitors J. Immunol., October 1, 1999; 163(7): 3612 - 3620. [Abstract] [Full Text] [PDF] R. Tordjman, N. Ortega, L. Coulombel, J. Plouet, P.-H. Romeo, and V. Lemarchandel Neuropilin-1 Is Expressed on Bone Marrow Stromal Cells: A Novel Interaction With Hematopoietic Cells? Blood, October 1, 1999; 94(7): 2301 - 2309. [Abstract] [Full Text] [PDF] V. C. Broudy, N. L. Lin, W. C. Liles, S. J. Corey, B. O'Laughlin, S. Mou, and D. Linnekin Signaling via Src Family Kinases Is Required for Normal Internalization of the Receptor c-Kit Blood, September 15, 1999; 94(6): 1979 - 1986. [Abstract] [Full Text] [PDF] C. H. Kim, C.-K. Qu, G. Hangoc, S. Cooper, N. Anzai, G.-S. Feng, and H. E. Broxmeyer Abnormal Chemokine-Induced Responses of Immature and Mature Hematopoietic Cells from Motheaten Mice Implicate the Protein Tyrosine Phosphatase Shp-1 in Chemokine Responses J. Exp. Med., September 6, 1999; 190(5): 681 - 690. [Abstract] [Full Text] [PDF] T. Kinoshita, T. Sekiguchi, M.-j. Xu, Y. Ito, A. Kamiya, K.-i. Tsuji, T. Nakahata, and A. Miyajima Hepatic differentiation induced by oncostatin M attenuates fetal liver hematopoiesis PNAS, June 22, 1999; 96(13): 7265 - 7270. [Abstract] [Full Text] [PDF] K. Kawabata, M. Ujikawa, T. Egawa, H. Kawamoto, K. Tachibana, H. Iizasa, Y. Katsura, T. Kishimoto, and T. Nagasawa A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution PNAS, May 11, 1999; 96(10): 5663 - 5667. [Abstract] [Full Text] [PDF] S. Reid, A. Ritchie, L. Boring, J. Gosling, S. Cooper, G. Hangoc, I. F. Charo, and H. E. Broxmeyer Enhanced Myeloid Progenitor Cell Cycling and Apoptosis in Mice Lacking the Chemokine Receptor, CCR2 Blood, March 1, 1999; 93(5): 1524 - 1533. [Abstract] [Full Text] [PDF] A. Peled, I. Petit, O. Kollet, M. Magid, T. Ponomaryov, T. Byk, A. Nagler, H. Ben-Hur, A. Many, L. Shultz, et al. Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4 Science, February 5, 1999; 283(5403): 845 - 848. [Abstract] [Full Text] S. W. Cole, B. D. Jamieson, and J. A. Zack cAMP Up-Regulates Cell Surface Expression of Lymphocyte CXCR4: Implications for Chemotaxis and HIV-1 Infection J. Immunol., February 1, 1999; 162(3): 1392 - 1400. [Abstract] [Full Text] [PDF] D. Parichy, J. Rawls, S. Pratt, T. Whitfield, and S. Johnson Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development Development, January 8, 1999; 126(15): 3425 - 3436. [Abstract] [PDF] P. Dutt, J.-F. Wang, and J. E. Groopman Stromal Cell-Derived Factor-1{alpha} and Stem Cell Factor/kit Ligand Share Signaling Pathways in Hemopoietic Progenitors: A Potential Mechanism for Cooperative Induction of Chemotaxis J. Immunol., October 1, 1998; 161(7): 3652 - 3658. [Abstract] [Full Text] [PDF] C. H. Kim, L. M. Pelus, J. R. White, and H. E. Broxmeyer Macrophage-Inflammatory Protein-3{beta}/EBI1-Ligand Chemokine/CK{beta}-11, a CC Chemokine, Is a Chemoattractant with a Specificity for Macrophage Progenitors Among Myeloid Progenitor Cells J. Immunol., September 1, 1998; 161(5): 2580 - 2585. [Abstract] [Full Text] [PDF] T. Hamada, R. Mohle, J. Hesselgesser, J. Hoxie, R. L. Nachman, M. A.S. Moore, and S. Rafii Transendothelial Migration of Megakaryocytes in Response to Stromal Cell-derived Factor 1 (SDF-1) Enhances Platelet Formation J. Exp. Med., August 3, 1998; 188(3): 539 - 548. [Abstract] [Full Text] [PDF] J.-F. Wang, Z.-Y. Liu, and J. E. Groopman The alpha -Chemokine Receptor CXCR4 Is Expressed on the Megakaryocytic Lineage From Progenitor to Platelets and Modulates Migration and Adhesion Blood, August 1, 1998; 92(3): 756 - 764. [Abstract] [Full Text] [PDF] C. H. Kim, L. M. Pelus, J. R. White, and H. E. Broxmeyer Differential Chemotactic Behavior of Developing T Cells in Response to Thymic Chemokines Blood, June 15, 1998; 91(12): 4434 - 4443. [Abstract] [Full Text] [PDF] C. H. Kim, L. M. Pelus, J. R. White, E. Applebaum, K. Johanson, and H. E. Broxmeyer CK{beta}-11/Macrophage Inflammatory Protein-3{beta}/EBI1-Ligand Chemokine Is an Efficacious Chemoattractant for T and B Cells J. Immunol., March 1, 1998; 160(5): 2418 - 2424. [Abstract] [Full Text] [PDF]

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