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Generation of Plasma Cells From Peripheral Blood Memory B Cells:
Synergistic Effect of Interleukin-10 and CD27/CD70 Interaction
Kazunaga Agematsu,
Haruo Nagumo,
Yumiko Oguchi,
Takayuki Nakazawa,
Keitaro Fukushima,
Kozo Yasui,
Susumu Ito,
Tetsuji Kobata,
Chikao Morimoto, and
Atsushi Komiyama
From the Departments of Pediatrics and Blood Transfusion,
Shinshu University School of Medicine, Matsumoto;
Department of Immunology, Juntendo University School of Medicine,
Tokyo, Japan; and Division of Tumor Immunology, Dana-Farber Cancer
Institute, Harvard Medical School, Boston, MA.
B cells can differentiate into the antibody-secreting cells, plasma
cells, whereas the crucial signals that positively control the entry
into the pathway to plasma cells have been unclear. Triggering via CD27
by CD27 ligand (CD70) on purified peripheral blood B cells yielded an
increase in the number of plasma cells in the presence of
interleukin-10 (IL-10). Differentiation into plasma cells by a
combination of IL-10 and CD70 transfectants occurred in
CD27+ B cells but not in CD27 B cells.
Moreover, addition of IL-2 to the IL-10 and CD70-transfect activation
system greatly induced differentiation into plasma cells. In the
presence of only IL-2, IL-4, or IL-6, CD70 transfectants did not
promote differentiation into plasma cells. On the other hand, CD40
signaling increased the expansion of a B-cell pool from peripheral
blood B cells primarily activated by IL-2, IL-10, and anti-CD40
monoclonal antibody (MoAb). Finally, CD27 signaling also rescued B
cells from IL-10-mediated apoptosis. These data demonstrate that CD27
ligand (CD70) is a key molecule to prevent the IL-10-mediated
promotion of apoptosis and to direct the differentiation of
CD27+ memory B cells toward plasma cells in cooperation
with IL-10.
Blood, Vol. 91 No. 1 (January 1), 1998:
pp. 173-180
© 1998 by The American Society of Hematology.
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