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Clinical Value of Soluble IgG Fc Receptor Type III in Plasma From
Patients With Chronic Idiopathic Neutropenia
Harry R. Koene,
Masja de Haas,
Marion Kleijer,
Tom W.J. Huizinga,
Dirk Roos, and
Albert E.G.Kr. von dem Borne
From the Central Laboratory of the Netherlands Red Cross Blood
Transfusion Service and Laboratory for Experimental and Clinical
Immunology, and Department of Hematology, Academic Medical Centre,
University of Amsterdam, Amsterdam, The Netherlands; and the Department
of Rheumatology, University Hospital Leiden, Leiden, The
Netherlands.
Previous studies have shown that the plasma level of soluble IgG Fc
receptor type III (sFc RIII) is a measure of the total body
neutrophil mass. The aim of this study was to determine whether the
plasma level sFcRIII is associated with the risk of contracting bacterial infections in patients with neutropenia. We collected blood
from 66 patients suffering from acquired idiopathic neutropenia, whose
blood was sent to our laboratory for diagnostic evaluation of
neutropenia (neutrophil count <1,500 cells/µL). Soluble FcRIII levels were measured in plasma. Genotype distibutions of FcR polymorphisms were determined. Clinical data were obtained from the
patient files. Patients were assessed as to whether or not they had
suffered from a bacterial infection 3 months before to 3 months after a
single sFcRIII measurement. In addition, longitudinal data were
obtained from 21 patients. Of the 66 neutropenic patients who were
included, 15 had suffered from a bacterial infection in the period 3 months before to 3 months after sFcRIII measurement. The age and sex
distribution was equal among the groups with and without infections, as
were the genotype frequencies of neutrophil FcR polymorphisms. Both
neutrophil count and plasma level sFcRIII were significantly lower
in the patient group with infections, compared with the noninfected
group (P = .03 and P < .0001, respectively). No
infections were reported for patients who had plasma sFcRIII levels
above 100 arbitrary units (AU; normal value, 30 to 200). After matching each infected patient with two noninfected patients having the same neutrophil count, sFcRIII plasma levels remained significantly lower in the group with infections (P = .0001). For the patients who were followed in time, no infections were reported
when sFcRIII levels were above 100 AU. In conclusion, our population
of patients with chronic idiopathic neutropenia with plasma sFcRIII
levels above 100 AU did not show an increased risk of contracting
bacterial infections.
Blood, Vol. 91 No. 10 (May 15), 1998:
pp. 3962-3966
© 1998 by The American Society of Hematology.
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