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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Varnum-Finney, B. Articles by Bernstein, I. D. Search for Related Content PubMed PubMed Citation Articles by Varnum-Finney, B. Articles by Bernstein, I. D. Related Collections Hematopoiesis and Stem Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells Barbara Varnum-Finney, Louise E. Purton, Monica Yu, Carolyn Brashem-Stein, David Flowers, Steven Staats, Kateri A. Moore, Isabelle Le Roux, Robert Mann, Grace Gray, Spyros Artavanis-Tsakonas, and Irwin D. Bernstein From the Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; the Department of Pediatrics, The University of Washington, Seattle; the Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, NJ; Developmental Genetics Laboratory, Imperial Cancer Research Fund, London, UK; and the Departments of Biology and Cell Biology and Howard Hughes Medical Institute, Yale University, New Haven, CT. We examined the expression of two members of the Notch family, Notch-1 and Notch-2, and one Notch ligand, Jagged-1, in hematopoietic cells. Both Notch-1 and Notch-2 were detected in murine marrow precursors (LinSca-1+c-kit+). The Notch ligand, Jagged-1, was not detected in whole marrow or in precursors. However, Jagged-1 was seen in cultured primary murine fetal liver stroma, cultured primary murine bone marrow stroma, and in stromal cell lines. These results indicate a potential role for Notch-Notch ligand interactions in hematopoiesis. To further test this possibility, the effect of Jagged-1 on murine marrow precursor cells was assessed by coculturing sorted precursor cells (LinSca-1+c-kit+) with a 3T3 cell layer that expressed human Jagged-1 or by incubating sorted precursors with beads coated with the purified extracellular domain of human Jagged-1 (Jagged-1ext). We found that Jagged-1, presented both on the cell surface and on beads, promoted a twofold to threefold increase in the formation of primitive precursor cell populations. These results suggest a potential use for Notch ligands in expanding precursor cell populations in vitro. Blood, Vol. 91 No. 11 (June 1), 1998: pp. 4084-4091 © 1998 by The American Society of Hematology. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Lahmar, C. Catelain, S. Poirault, M. Dorsch, J.-L. Villeval, W. Vainchenker, O. Albagli, and E. Lauret Distinct Effects of the Soluble Versus Membrane-Bound Forms of the Notch Ligand Delta-4 on Human CD34+CD38low Cell Expansion and Differentiation Stem Cells, March 1, 2008; 26(3): 621 - 629. [Abstract] [Full Text] [PDF] L. M. Calvi Hematopoietic-Osteoblastic Interactions in the Hematopoietic Stem Cell Niche IBMS BoneKEy, May 1, 2006; 3(5): 10 - 18. [Abstract] [Full Text] [PDF] C. Delaney, B. Varnum-Finney, K. Aoyama, C. Brashem-Stein, and I. D. Bernstein Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells Blood, October 15, 2005; 106(8): 2693 - 2699. [Abstract] [Full Text] [PDF] N. Hoshino, N. Katayama, T. Shibasaki, K. Ohishi, J. Nishioka, M. Masuya, Y. Miyahara, M. 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