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Characterization of a Novel CC Chemokine, HCC-4, Whose Expression
Is Increased by Interleukin-10
Joseph A. Hedrick,
Allison Helms,
Alain Vicari, and
Albert Zlotnik
From DNAX Research Institute, Palo Alto, CA.
We have identified and characterized a human  (CC) chemokine,
designated HCC-4, that is most closely related to HCC-1 and which
demonstrates chemotactic activity for monocytes. Northern analysis of
multiple tissue blots and of activated monocytes mRNA shows expression
of a 500-bp mRNA. A 1,500-bp mRNA was highly expressed in monocytes
activated 12 hours in the presence of interleukin-10 (IL-10) but was
absent in monocytes activated for only 1 hour regardless of the
presence or absence of IL-10. The upregulation of expression in the
presence of IL-10 is in contrast to the downregulatory effects of IL-10
on expression of most other chemokines. Recombinant HCC-4 demonstrated
chemotactic activity for human monocytes and THP-1 monocyte cells but
not for resting lymphocytes or neutrophils. HCC-4 also induced a
Ca2+ flux in THP-1 cells that was desensitized by prior
exposure to RANTES. Taken together, these data indicate that HCC-4 is a
novel chemokine whose expression is uniquely upregulated by IL-10.
Blood, Vol. 91 No. 11 (June 1), 1998:
pp. 4242-4247
© 1998 by The American Society of Hematology.
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