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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Jeremias, I. Articles by Debatin, K.M. Search for Related Content PubMed PubMed Citation Articles by Jeremias, I. Articles by Debatin, K.M. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Inhibition of Nuclear Factor B Activation Attenuates Apoptosis Resistance in Lymphoid Cells I. Jeremias, C. Kupatt, B. Baumann, I. Herr, T. Wirth, and K.M. Debatin From the Division of Molecular Oncology, Deutsches Krebsforschungszentrum, Heidelberg, Germany; the Department of Physiology, University Munich, Germany; the Institut für Medizinische Strahlenkunde und Zellforschung, University Würzburg, Germany; and the University Childrens' Hospital, Ulm, Germany. Death-inducing ligands (DILs) such as tumor necrosis factor  (TNF) or the cytotoxic drug doxorubicin have been shown to activate a nuclear factor B (NFB)-dependent program that may rescue cells from apoptosis induction. We demonstrate here that TRAIL (TNF-related apoptosis-inducing ligand), a recently identified DIL, also activates NFB in lymphoid cell lines in a kinetic similar to TNF. NFB activity is independent from FADD, caspases, and apoptosis induction. To study the influence of NFB activity on apoptosis mediated by TRAIL, CD95, TNF, or doxorubicin, NFB activation was inhibited using the proteasome inhibitor N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal or transient overexpression of mutant IB. Sensitivity for induction of apoptosis was markedly increased by these treatments in apoptosis sensitive cell lines. Moreover, both in cell lines and in primary leukemia cells that are resistant towards induction of apoptosis by DILs and doxorubicin, antagonization of NFB activity partially restored apoptosis sensitivity. These data suggest that inhibition of NFB activation may provide a molecular approach to increase apoptosis sensitivity in anticancer treatment. Blood, Vol. 91 No. 12 (June 15), 1998: pp. 4624-4631 © 1998 by The American Society of Hematology. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. Takeshima, K. Tomimori, H. Teruya, C. Ishikawa, M. 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MacFarlane Protein Kinase C Modulates Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis by Targeting the Apical Events of Death Receptor Signaling J. Biol. Chem., November 7, 2003; 278(45): 44338 - 44347. [Abstract] [Full Text] [PDF] A. Younes and M. E. Kadin Emerging Applications of the Tumor Necrosis Factor Family of Ligands and Receptors in Cancer Therapy J. Clin. Oncol., September 15, 2003; 21(18): 3526 - 3534. [Abstract] [Full Text] [PDF] Q. Pan, L. W. Bao, C. G. Kleer, G. J. Brewer, and S. D. Merajver Antiangiogenic Tetrathiomolybdate Enhances the Efficacy of Doxorubicin against Breast Carcinoma Mol. Cancer Ther., July 1, 2003; 2(7): 617 - 622. [Abstract] [Full Text] [PDF] T. J. Sayers, A. D. Brooks, C. Y. Koh, W. Ma, N. Seki, A. Raziuddin, B. R. Blazar, X. Zhang, P. J. Elliott, and W. J. Murphy The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP Blood, July 1, 2003; 102(1): 303 - 310. [Abstract] [Full Text] [PDF] C. M. Tato, A. Villarino, J. H. Caamano, M. Boothby, and C. A. Hunter Inhibition of NF-{kappa}B Activity in T and NK Cells Results in Defective Effector Cell Expansion and Production of IFN-{gamma} Required for Resistance to Toxoplasma gondii J. Immunol., March 15, 2003; 170(6): 3139 - 3146. [Abstract] [Full Text] [PDF] M. Leverkus, M. R. Sprick, T. Wachter, T. Mengling, B. Baumann, E. Serfling, E.-B. Brocker, M. Goebeler, M. Neumann, and H. Walczak Proteasome Inhibition Results in TRAIL Sensitization of Primary Keratinocytes by Removing the Resistance-Mediating Block of Effector Caspase Maturation Mol. Cell. Biol., February 1, 2003; 23(3): 777 - 790. [Abstract] [Full Text] I. Lavon, E. Pikarsky, E. Gutkovich, I. Goldberg, J. Bar, M. Oren, and Y. Ben-Neriah Nuclear Factor-{kappa}B Protects the Liver against Genotoxic Stress and Functions Independently of p53 Cancer Res., January 1, 2003; 63(1): 25 - 30. [Abstract] [Full Text] [PDF] B. Baumann, F. Bohnenstengel, D. Siegmund, H. Wajant, C. Weber, I. Herr, K.-M. Debatin, P. Proksch, and T. Wirth Rocaglamide Derivatives Are Potent Inhibitors of NF-kappa B Activation in T-cells J. Biol. Chem., November 15, 2002; 277(47): 44791 - 44800. [Abstract] [Full Text] [PDF] B. Lu, L. Wang, D. Medan, D. Toledo, C. Huang, F. Chen, X. Shi, and Y. Rojanasakul Regulation of Fas (CD95)-induced apoptosis by nuclear factor-kappa B and tumor necrosis factor-alpha in macrophages Am J Physiol Cell Physiol, September 1, 2002; 283(3): C831 - C838. [Abstract] [Full Text] [PDF] N. Mitsiades, C. S. Mitsiades, V. Poulaki, D. Chauhan, P. G. Richardson, T. Hideshima, N. Munshi, S. P. Treon, and K. C. Anderson Biologic sequelae of nuclear factor-kappa B blockade in multiple myeloma: therapeutic applications Blood, May 13, 2002; 99(11): 4079 - 4086. [Abstract] [Full Text] [PDF] A. Arlt, J. Vorndamm, S. Muerkoster, H. Yu, W. E. Schmidt, U. R. Folsch, and H. Schafer Autocrine Production of Interleukin 1{beta} Confers Constitutive Nuclear Factor {kappa}B Activity and Chemoresistance in Pancreatic Carcinoma Cell Lines Cancer Res., February 1, 2002; 62(3): 910 - 916. [Abstract] [Full Text] [PDF] M. Nakayama, K. Ishidoh, N. Kayagaki, Y. Kojima, N. Yamaguchi, H. Nakano, E. Kominami, K. Okumura, and H. Yagita Multiple Pathways of TWEAK-Induced Cell Death J. Immunol., January 15, 2002; 168(2): 734 - 743. [Abstract] [Full Text] [PDF] I. Herr and K.-M. Debatin Cellular stress response and apoptosis in cancer therapy Blood, November 1, 2001; 98(9): 2603 - 2614. [Abstract] [Full Text] [PDF] M. Mori, Y. Terui, M. Tanaka, H. Tomizuka, Y. Mishima, M. Ikeda, T. Kasahara, M. Uwai, M. Ueda, R. Inoue, et al. Antitumor Effect of {beta}2-Microglobulin in Leukemic Cell-bearing Mice via Apoptosis-inducing Activity: Activation of Caspase-3 and Nuclear Factor-{{kappa}}B Cancer Res., June 1, 2001; 61(11): 4414 - 4417. [Abstract] [Full Text] [PDF] A. V. Franco, X. D. Zhang, E. Van Berkel, J. E. Sanders, X. Y. Zhang, W. D. Thomas, T. Nguyen, and P. Hersey The Role of NF-{{kappa}}B in TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis of Melanoma Cells J. Immunol., May 1, 2001; 166(9): 5337 - 5345. [Abstract] [Full Text] [PDF] N.-E. El Mahdani, M. Ameyar, Z. Cai, O. Colard, J. Masliah, and S. Chouaib Resistance to TNF-Induced Cytotoxicity Correlates with an Abnormal Cleavage of Cytosolic Phospholipase A2 J. Immunol., December 15, 2000; 165(12): 6756 - 6761. [Abstract] [Full Text] [PDF] J. Caamano, C. Tato, G. Cai, E. N. Villegas, K. Speirs, L. Craig, J. Alexander, and C. A. Hunter Identification of a Role for NF-{kappa}B2 in the Regulation of Apoptosis and in Maintenance of T Cell-Mediated Immunity to Toxoplasma gondii J. Immunol., November 15, 2000; 165(10): 5720 - 5728. [Abstract] [Full Text] [PDF] Y. Lin, A. Devin, A. Cook, M. M. Keane, M. Kelliher, S. Lipkowitz, and Z.-g. Liu The Death Domain Kinase RIP Is Essential for TRAIL (Apo2L)-Induced Activation of Ikappa B Kinase and c-Jun N-Terminal Kinase Mol. Cell. Biol., September 15, 2000; 20(18): 6638 - 6645. [Abstract] [Full Text] C. M. Mueller and D. W. Scott Distinct Molecular Mechanisms of Fas Resistance in Murine B Lymphoma Cells J. Immunol., August 15, 2000; 165(4): 1854 - 1862. [Abstract] [Full Text] [PDF] P. Masdehors, H. Merle-Beral, K. Maloum, S. Omura, H. Magdelenat, and J. Delic Deregulation of the ubiquitin system and p53 proteolysis modify the apoptotic response in B-CLL lymphocytes Blood, July 1, 2000; 96(1): 269 - 274. [Abstract] [Full Text] [PDF] X. D. Zhang, A. V. Franco, T. Nguyen, C. P. Gray, and P. Hersey Differential Localization and Regulation of Death and Decoy Receptors for TNF-Related Apoptosis-Inducing Ligand (TRAIL) in Human Melanoma Cells J. Immunol., April 15, 2000; 164(8): 3961 - 3970. [Abstract] [Full Text] [PDF] I. Ponzanelli, M. Gianni, R. Giavazzi, A. Garofalo, I. Nicoletti, U. Reichert, E. Erba, A. Rambaldi, M. Terao, and E. Garattini Isolation and characterization of an acute promyelocytic leukemia cell line selectively resistant to the novel antileukemic and apoptogenic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid Blood, April 15, 2000; 95(8): 2672 - 2682. [Abstract] [Full Text] [PDF] J. Feuillard, M. Schuhmacher, S. Kohanna, M. Asso-Bonnet, F. Ledeur, R. Joubert-Caron, P. Bissieres, A. Polack, G. W. Bornkamm, and M. Raphael Inducible loss of NF-kappa B activity is associated with apoptosis and Bcl-2 down-regulation in Epstein-Barr virus-transformed B lymphocytes Blood, March 15, 2000; 95(6): 2068 - 2075. [Abstract] [Full Text] [PDF] V. Kolenko, T. Bloom, P. Rayman, R. Bukowski, E. Hsi, and J. Finke Inhibition of NF-{kappa}B Activity in Human T Lymphocytes Induces Caspase-Dependent Apoptosis Without Detectable Activation of Caspase-1 and -3 J. Immunol., July 15, 1999; 163(2): 590 - 598. [Abstract] [Full Text] [PDF] L. M. Sedger, D. M. Shows, R. A. Blanton, J. J. Peschon, R. G. Goodwin, D. Cosman, and S. R. Wiley IFN-{gamma} Mediates a Novel Antiviral Activity Through Dynamic Modulation of TRAIL and TRAIL Receptor Expression J. Immunol., July 15, 1999; 163(2): 920 - 926. [Abstract] [Full Text] [PDF] A. Orlofsky, R. D. Somogyi, L. M. Weiss, and M. B. Prystowsky The Murine Antiapoptotic Protein A1 Is Induced in Inflammatory Macrophages and Constitutively Expressed in Neutrophils J. Immunol., July 1, 1999; 163(1): 412 - 419. [Abstract] [Full Text] [PDF] L. Klampfer, J. Cammenga, H.-G. Wisniewski, and S. D. Nimer Sodium Salicylate Activates Caspases and Induces Apoptosis of Myeloid Leukemia Cell Lines Blood, April 1, 1999; 93(7): 2386 - 2394. [Abstract] [Full Text] [PDF] G. Kothny-Wilkes, D. Kulms, B. Poppelmann, T. A. Luger, M. Kubin, and T. Schwarz Interleukin-1 Protects Transformed Keratinocytes from Tumor Necrosis Factor-related Apoptosis-inducing Ligand J. Biol. Chem., October 30, 1998; 273(44): 29247 - 29253. [Abstract] [Full Text] [PDF] S.-Y. Hong, W.-H. Yoon, J.-H. Park, S.-G. Kang, J.-H. Ahn, and T. H. Lee Involvement of Two NF-kappa B Binding Elements in Tumor Necrosis Factor alpha -, CD40-, and Epstein-Barr Virus Latent Membrane Protein 1-mediated Induction of the Cellular Inhibitor of Apoptosis Protein 2 Gene J. Biol. Chem., June 9, 2000; 275(24): 18022 - 18028. [Abstract] [Full Text] [PDF] N. Harper, S. N. Farrow, A. Kaptein, G. M. Cohen, and M. MacFarlane Modulation of Tumor Necrosis Factor Apoptosis-inducing Ligand- induced NF-kappa B Activation by Inhibition of Apical Caspases J. Biol. Chem., September 7, 2001; 276(37): 34743 - 34752. [Abstract] [Full Text] [PDF] X. Bian, L. M. McAllister-Lucas, F. Shao, K. R. Schumacher, Z. Feng, A. G. Porter, V. P. Castle, and A. W. Opipari Jr. NF-kappa B Activation Mediates Doxorubicin-induced Cell Death in N-type Neuroblastoma Cells J. Biol. Chem., December 21, 2001; 276(52): 48921 - 48929. [Abstract] [Full Text] [PDF]

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