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De Novo CD5+ Diffuse Large B-Cell Lymphomas Express
VH Genes With Somatic Mutation
Masanori Taniguchi,
Kouji Oka,
Atsunori Hiasa,
Motoko Yamaguchi,
Toshiyuki Ohno,
Kenkichi Kita, and
Hiroshi Shiku
From The Second Department of Internal Medicine, Mie University
School of Medicine, Tsu, Japan.
To clarify the cellular origin of de novo CD5+ diffuse
large B-cell lymphoma (CD5+ DLBL), particularly in
comparison with other CD5+ B-cell neoplasms such as
chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), we
analyzed the nucleotide sequence of the Ig heavy chain variable region
(IgVH) genes of de novo CD5+ DLBL cases. All 4 cases
examined had extensive somatic mutations in contrast with CLL or MCL.
The VH gene sequences of de novo CD5+ DLBL displayed
86.9% to 95.2% homology with the corresponding germlines, whereas
those of simultaneously analyzed CLL and MCL displayed 97.6% to 100%
homology. The VH family used was VH3 in 1 case, VH4 in 2 cases, and VH5
in 1 case. In 2 of 4 examined cases, the distribution of replacement
and silent mutations over the complementarity determining region and
framework region in the VH genes was compatible with the pattern
resulting from the antigen selection. Clinically, CD5+
DLBL frequently involved a variety of extranodal sites (12/13) and
lymph node (11/13). Immunophenotypically, CD5+ DLBL
scarcely expressed CD21 and CD23 (3/13 and 2/13, respectively). These
findings indicate that de novo CD5+ DLBL cells are
derived from a B-1 subset distinct from those of CLL or MCL.
Blood, Vol. 91 No. 4 (February 15), 1998:
pp. 1145-1151
© 1998 by The American Society of Hematology.
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