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No Neuronal Regulation of Murine Bone Marrow Function
Haakon B. Benestad,
Inger Strøm-Gundersen,
Per Ole Iversen,
Egil Haug, and
Arild Njå
From the Departments of Physiology and Neurophysiology, Institute of
Basic Medical Sciences, The University of Oslo, and The Hormone
Laboratory, Aker Hospital, Oslo, Norway.
Bone marrow is innervated by efferent (sympathetic) and afferent
nerves, but it is not clear whether these nerves affect cell formation
or release in any significant way. To elucidate this problem, we
studied mice neonatally sympathectomized with 6-hydroxydopamine and
adult mice in which one hind limb was surgically denervated. Progenitor
and transit cell numbers and proliferative activity were estimated in
bone marrow, blood, and spleen. In addition, we performed unilateral
electrical stimulation of nerve fibers to tibial marrow and applied a
cell mobilizing stimulus (bleeding, granulocyte colony-stimulating
factor injection, or intraperitoneal injection of a chemotactic
substance) to investigate cell egress from the marrow. Blood flow to
hindleg bone marrow was assessed with the radioactive microsphere
technique. Except for a smaller bone marrow cell population and lower
body weight in neonatally sympathectomized mice, we found no clear
indications that bone marrow innervation influenced cell production.
Also, the innervation did not detectably affect cell release from the
marrow. Electrical stimulation of hind limb nerves did not change the
blood flow to the marrow, whereas it markedly decreased blood flow to
the overlying muscle. We therefore conclude that no obvious function can be ascribed to tibial marrow innervation in the mouse.
Blood, Vol. 91 No. 4 (February 15), 1998:
pp. 1280-1287
© 1998 by The American Society of Hematology.
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