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Ligneous Conjunctivitis in Plasminogen-Deficient Mice
A.F. Drew,
A.H. Kaufman,
K.W. Kombrinck,
M.J.S. Danton,
C.C. Daugherty,
J.L. Degen, and
T.H. Bugge
From the Divisions of Developmental Biology and Pathology,
Children's Hospital Research Foundation; and the Department of
Ophthalmology, University of Cincinnati, Cincinnati, OH.
Ligneous conjunctivitis is a rare form of chronic pseudomembranous
conjunctivitis that is associated with systemic membranous pathological
changes. A probable link between plasminogen and ligneous
conjunctivitis has been indicated by the recent diagnoses of
plasminogen deficiency in five patients suffering from ligneous conjunctivitis. The current study reports that plasminogen-deficient mice develop conjunctival lesions indistinguishable from human ligneous
conjunctivitis in both appearance and histology. Both human and mouse
lesions contain acellular material rich in fibrin, and aberrant or
disrupted epithelium. The incidence of lesion development in mice
increases with age and is strongly influenced by genetic background.
Interestingly, ligneous conjunctivitis was not observed in
plasminogen-deficient mice simultaneously lacking fibrinogen. This
study provides direct evidence that plasminogen deficiency is one cause
of ligneous conjunctivitis and suggests that plasminogen-deficient mice
may be an excellent model for the development of therapeutic strategies
for the treatment of this debilitating disease.
Blood, Vol. 91 No. 5 (March 1), 1998:
pp. 1616-1624
© 1998 by The American Society of Hematology.
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