|
|
 Previous Article | Table of Contents | Next Article 
Interleukin-18 Regulation of Interferon  Production and Cell
Proliferation as Shown in Interleukin-1 -Converting Enzyme
(Caspase-1)-Deficient Mice
Giamila Fantuzzi,
Adrian J. Puren,
Matthew W. Harding,
David J. Livingston, and
Charles A. Dinarello
From the Division of Infectious Diseases, University of Colorado
Health Sciences Center, Denver, CO; and the Vertex Pharmaceuticals,
Inc, Cambridge, MA.
Interleukin-18 (IL-18) is a costimulatory factor for interferon
(IFN) production. Processing of pro-IL-18 by IL-1 -converting enzyme (ICE) leads to the release of bioactive IL-18. Compared with
wild-type (WT) mice, splenocytes from ICE-deficient mice produced low
IFN after lipopolysaccharide (LPS) or zymosan (50% and 80%
reduction). In contrast, IFN production was unimpaired in
ICE-deficient mice using Concanavalin A (Con A). Comparable results
were obtained when endogenous IL-18 was blocked with a neutralizing
antibody. LPS-induced IFN was also reduced by an ICE inhibitor.
Exogenous IL-18 augmented zymosan-induced IFN production in WT mice.
In ICE-deficient cells, IFN production was only partially restored
by IL-18. The reduced levels of IFN in ICE-deficient mice were not
due to a lack of IL-12, because zymosan induced IL-12 equally in WT and
in ICE-deficient mice. IFN is an important regulator of cell
proliferation. In accordance, splenocytes from ICE-deficient mice
proliferated more when stimulated with LPS, but not with Con A. Furthermore, in ovalbumin-sensitized ICE-deficient mice, proliferation
of lymph node cells in response to the specific antigen was not
altered. Exogenous IFN inhibited, whereas blockade of endogenous
IFN or IL-18 increased, LPS induced splenocyte proliferation both in
WT and in ICE-deficient mice. Our results show that IL-18 is an
IL-12-independent regulator of IFN production and of cell
proliferation induced by microbial stimuli. However, ICE-dependent
processing of IL-18 is not needed for response to mitogens or antigens.
Blood, Vol. 91 No. 6 (March 15), 1998:
pp. 2118-2125
© 1998 by The American Society of Hematology.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
S. G. Coca and C. R. Parikh
Urinary Biomarkers for Acute Kidney Injury: Perspectives on Translation
Clin. J. Am. Soc. Nephrol.,
March 1, 2008;
3(2):
481 - 490.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. L. Edelstein, T. S. Hoke, H. Somerset, W. Fang, C. L. Klein, C. A. Dinarello, and S. Faubel
Proximal tubules from caspase-1-deficient mice are protected against hypoxia-induced membrane injury
Nephrol. Dial. Transplant.,
April 1, 2007;
22(4):
1052 - 1061.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Omoto, K. Tokime, K. Yamanaka, K. Habe, T. Morioka, I. Kurokawa, H. Tsutsui, K. Yamanishi, K. Nakanishi, and H. Mizutani
Human Mast Cell Chymase Cleaves Pro-IL-18 and Generates a Novel and Biologically Active IL-18 Fragment
J. Immunol.,
December 15, 2006;
177(12):
8315 - 8319.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Wang, E. Zolty, S. Falk, V. Basava, L. Reznikov, and R. Schrier
Pentoxifylline protects against endotoxin-induced acute renal failure in mice
Am J Physiol Renal Physiol,
November 1, 2006;
291(5):
F1090 - F1095.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Imeri, S. Bianchi, and M. R. Opp
Inhibition of caspase-1 in rat brain reduces spontaneous nonrapid eye movement sleep and nonrapid eye movement sleep enhancement induced by lipopolysaccharide
Am J Physiol Regulatory Integrative Comp Physiol,
July 1, 2006;
291(1):
R197 - R204.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Greene, J. L. DeVecchio, M. P. Gould, J. J. Auletta, and F. P. Heinzel
In vivo and In vitro Regulation of Type I IFN Synthesis by Synergistic Effects of CD40 and Type II IFN
J. Immunol.,
May 15, 2006;
176(10):
5995 - 6003.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Londono, Y. Bai, W. R. Zuckert, H. Gelderblom, and D. Cadavid
Cardiac Apoptosis in Severe Relapsing Fever Borreliosis
Infect. Immun.,
November 1, 2005;
73(11):
7669 - 7676.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Wang, S. Faubel, D. Ljubanovic, A. Mitra, S. A. Falk, J. Kim, Y. Tao, A. Soloviev, L. L. Reznikov, C. A. Dinarello, et al.
Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice
Am J Physiol Renal Physiol,
May 1, 2005;
288(5):
F997 - F1004.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W.-X. Huang, P. Huang, and J. Hillert
Increased expression of caspase-1 and interleukin-18 in peripheral blood mononuclear cells in patients with multiple sclerosis
Multiple Sclerosis,
October 1, 2004;
10(5):
482 - 487.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. Taube, J. A. Nick, B. Siegmund, C. Duez, K. Takeda, Y.-H. Rha, J.-W. Park, A. Joetham, K. Poch, A. Dakhama, et al.
Inhibition of Early Airway Neutrophilia Does Not Affect Development of Airway Hyperresponsiveness
Am. J. Respir. Cell Mol. Biol.,
June 1, 2004;
30(6):
837 - 843.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. G. Rothfuchs, C. Trumstedt, H. Wigzell, and M. E. Rottenberg
Intracellular Bacterial Infection-Induced IFN-{gamma} Is Critically but Not Solely Dependent on Toll-Like Receptor 4-Myeloid Differentiation Factor 88-IFN-{alpha}{beta}-STAT1 Signaling
J. Immunol.,
May 15, 2004;
172(10):
6345 - 6353.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Airoldi, L. Raffaghello, C. Cocco, R. Guglielmino, S. Roncella, F. Fedeli, C. Gambini, and V. Pistoia
Heterogeneous Expression of Interleukin-18 and Its Receptor in B-Cell Lymphoproliferative Disorders Deriving from Naive, Germinal Center, and Memory B Lymphocytes
Clin. Cancer Res.,
January 1, 2004;
10(1):
144 - 154.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Fantuzzi, N. K. Banda, C. Guthridge, A. Vondracek, S.-H. Kim, B. Siegmund, T. Azam, J. A. Sennello, C. A. Dinarello, and W. P. Arend
Generation and characterization of mice transgenic for human IL-18-binding protein isoform a
J. Leukoc. Biol.,
November 1, 2003;
74(5):
889 - 896.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Weijer, M. E. Sewnath, A. F. de Vos, S. Florquin, K. van der Sluis, D. J. Gouma, K. Takeda, S. Akira, and T. van der Poll
Interleukin-18 Facilitates the Early Antimicrobial Host Response to Escherichia coli Peritonitis
Infect. Immun.,
October 1, 2003;
71(10):
5488 - 5497.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kalai, M. Lamkanfi, G. Denecker, M. Boogmans, S. Lippens, A. Meeus, W. Declercq, and P. Vandenabeele
Regulation of the expression and processing of caspase-12
J. Cell Biol.,
August 4, 2003;
162(3):
457 - 467.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. R. Brown, E. L. Lee, and D. L. Thiele
TNF Enhances CD4+ T Cell Alloproliferation, IFN-{gamma} Responses, and Intestinal Graft-Versus-Host Disease by IL-12-Independent Mechanisms
J. Immunol.,
May 15, 2003;
170(10):
5082 - 5088.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Gracie, S. E. Robertson, and I. B. McInnes
Interleukin-18
J. Leukoc. Biol.,
February 1, 2003;
73(2):
213 - 224.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. D. Joshi, D. V. Kalvakolanu, J. R. Hebel, J. D. Hasday, and A. S. Cross
Role of Caspase 1 in Murine Antibacterial Host Defenses and Lethal Endotoxemia
Infect. Immun.,
December 1, 2002;
70(12):
6896 - 6903.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. D. Joshi, D. V. Kalvakolanu, J. D. Hasday, R. J. Hebel, and A. S. Cross
IL-18 Levels and the Outcome of Innate Immune Response to Lipopolysaccharide: Importance of a Positive Feedback Loop with Caspase-1 in IL-18 Expression
J. Immunol.,
September 1, 2002;
169(5):
2536 - 2544.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. D. Raeburn, C. A. Dinarello, M. A. Zimmerman, C. M. Calkins, B. J. Pomerantz, R. C. McIntyre Jr., A. H. Harken, and X. Meng
Neutralization of IL-18 attenuates lipopolysaccharide-induced myocardial dysfunction
Am J Physiol Heart Circ Physiol,
August 1, 2002;
283(2):
H650 - H657.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Huang, S. A. McClellan, R. P. Barrett, and L. D. Hazlett
IL-18 Contributes to Host Resistance Against Infection with Pseudomonas aeruginosa Through Induction of IFN-{gamma} Production
J. Immunol.,
June 1, 2002;
168(11):
5756 - 5763.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Arnold, C. Wasem, P. Juillard, P. Graber, I. Cima, C. Frutschi, S. Herren, S. Jakob, S. Alouani, C. Mueller, et al.
IL-18-independent cytotoxic T lymphocyte activation and IFN-{gamma} production during experimental acute graft-versus-host disease
Int. Immunol.,
May 1, 2002;
14(5):
503 - 511.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Wang, C. Feliciani, B. G. Howell, I. Freed, Q. Cai, H. Watanabe, and D. N. Sauder
Contribution of Langerhans Cell-Derived IL-18 to Contact Hypersensitivity
J. Immunol.,
April 1, 2002;
168(7):
3303 - 3308.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Gatti, J. Beck, G. Fantuzzi, T. Bartfai, and C. A. Dinarello
Effect of interleukin-18 on mouse core body temperature
Am J Physiol Regulatory Integrative Comp Physiol,
March 1, 2002;
282(3):
R702 - R709.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Gerdes, G. K. Sukhova, P. Libby, R. S. Reynolds, J. L. Young, and U. Schonbeck
Expression of Interleukin (IL)-18 and Functional IL-18 Receptor on Human Vascular Endothelial Cells, Smooth Muscle Cells, and Macrophages: Implications for Atherogenesis
J. Exp. Med.,
January 22, 2002;
195(2):
245 - 257.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. N. Lauw, J. Branger, S. Florquin, P. Speelman, S. J. H. van Deventer, S. Akira, and T. van der Poll
IL-18 Improves the Early Antimicrobial Host Response to Pneumococcal Pneumonia
J. Immunol.,
January 1, 2002;
168(1):
372 - 378.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Faggioni, R. C. Cattley, J. Guo, S. Flores, H. Brown, M. Qi, S. Yin, D. Hill, S. Scully, C. Chen, et al.
IL-18-Binding Protein Protects Against Lipopolysaccharide- Induced Lethality and Prevents the Development of Fas/Fas Ligand-Mediated Models of Liver Disease in Mice
J. Immunol.,
November 15, 2001;
167(10):
5913 - 5920.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Esfandiari, I. B. McInnes, G. Lindop, F.-P. Huang, M. Field, M. Komai-Koma, X.-q. Wei, and F. Y. Liew
A Proinflammatory Role of IL-18 in the Development of Spontaneous Autoimmune Disease
J. Immunol.,
November 1, 2001;
167(9):
5338 - 5347.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C A Dinarello
Novel targets for interleukin 18 binding protein
Ann Rheum Dis,
November 1, 2001;
60(90003):
iii18 - 24.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. G. Mordue, F. Monroy, M. La Regina, C. A. Dinarello, and L. D. Sibley
Acute Toxoplasmosis Leads to Lethal Overproduction of Th1 Cytokines
J. Immunol.,
October 15, 2001;
167(8):
4574 - 4584.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Siegmund, G. Fantuzzi, F. Rieder, F. Gamboni-Robertson, H.-A. Lehr, G. Hartmann, C. A. Dinarello, S. Endres, and A. Eigler
Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production
Am J Physiol Regulatory Integrative Comp Physiol,
October 1, 2001;
281(4):
R1264 - R1273.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Mallat, A. Corbaz, A. Scoazec, P. Graber, S. Alouani, B. Esposito, Y. Humbert, Y. Chvatchko, and A. Tedgui
Interleukin-18/Interleukin-18 Binding Protein Signaling Modulates Atherosclerotic Lesion Development and Stability
Circ. Res.,
September 28, 2001;
89
(7):
e41 - e45.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. N. Lauw, S. Florquin, P. Speelman, S. J. H. van Deventer, and T. van der Poll
Role of Endogenous Interleukin-12 in Immune Response to Staphylococcal Enterotoxin B in Mice
Infect. Immun.,
September 1, 2001;
69(9):
5949 - 5952.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C Hanck, T Manigold, U Bocker, M Kurimoto, C B Kolbel, M V Singer, and S Rossol
Gene expression of interleukin 18 in unstimulated peripheral blood mononuclear cells of patients with alcoholic cirrhosis
Gut,
July 1, 2001;
49(1):
106 - 111.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Brewington, M. Chatterji, M. Zoubine, R. N. Miranda, M. Norimatsu, and A. Shnyra
IFN-{{gamma}}-Independent Autocrine Cytokine Regulatory Mechanism in Reprogramming of Macrophage Responses to Bacterial Lipopolysaccharide
J. Immunol.,
July 1, 2001;
167(1):
392 - 398.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Itoi, Y. Fujimori, H. Tsutsui, K. Matsui, S. Futatsugi, H. Okamura, H. Hara, T. Hada, E. Kakishita, and K. Nakanishi
Fas ligand-induced caspase-1-dependent accumulation of interleukin-18 in mice with acute graft-versus-host disease
Blood,
July 1, 2001;
98(1):
235 - 237.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. A. B. Joosten, F. A. J. van de Loo, E. Lubberts, M. M. A. Helsen, M. G. Netea, J. W. M. van der Meer, C. A. Dinarello, and W. B. van den Berg
An IFN-{gamma}-Independent Proinflammatory Role of IL-18 in Murine Streptococcal Cell Wall Arthritis
J. Immunol.,
December 1, 2000;
165(11):
6553 - 6558.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Fiorucci, L. Santucci, G. Cirino, A. Mencarelli, L. Familiari, P. D. Soldato, and A. Morelli
IL-1{beta} Converting Enzyme Is a Target for Nitric Oxide-Releasing Aspirin: New Insights in the Antiinflammatory Mechanism of Nitric Oxide-Releasing Nonsteroidal Antiinflammatory Drugs
J. Immunol.,
November 1, 2000;
165(9):
5245 - 5254.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-K. Lee, D. T. Rao, R. Gertner, R. Gimeno, A. B. Frey, and D. E. Levy
Distinct Requirements for IFNs and STAT1 in NK Cell Function
J. Immunol.,
October 1, 2000;
165(7):
3571 - 3577.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Mencacci, A. Bacci, E. Cenci, C. Montagnoli, S. Fiorucci, A. Casagrande, R. A. Flavell, F. Bistoni, and L. Romani
Interleukin 18 Restores Defective Th1 Immunity to Candida albicans in Caspase 1-Deficient Mice
Infect. Immun.,
September 1, 2000;
68(9):
5126 - 5131.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Monack, D. Hersh, N. Ghori, D. Bouley, A. Zychlinsky, and S. Falkow
Salmonella Exploits Caspase-1 to Colonize Peyer's Patches in a Murine Typhoid Model
J. Exp. Med.,
July 17, 2000;
192(2):
249 - 258.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. H. Glimcher and K. M. Murphy
Lineage commitment in the immune system: the T helper lymphocyte grows up
Genes & Dev.,
July 15, 2000;
14(14):
1693 - 1711.
[Full Text]
|
|
|
|
