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Rat Neutrophils Express  4 and  1 Integrins and Bind to
Vascular Cell Adhesion Molecule-1 (VCAM-1) and Mucosal Addressin
Cell Adhesion Molecule-1 (MAdCAM-1)
Kelly L. Davenpeck,
Sherry A. Sterbinsky, and
Bruce S. Bochner
From the Department of Medicine, Division of Clinical Immunology, The
Johns Hopkins University School of Medicine, JHAAC, Baltimore, MD.
The  4 integrins, which are constitutively expressed on all human
leukocyte subtypes except neutrophils, interact with vascular cell
adhesion molecule-1 (VCAM-1) and mucosal addressin cell adhesion molecule (MAdCAM-1) on endothelium to mediate selective recruitment of
leukocyte subpopulations, other than neutrophils, to sites of
inflammation. However, here we report that a different paradigm of
leukocyte recruitment may exist in the rat. Flow cytometric analysis of
rat neutrophils using a panel of monoclonal antibodies which recognize
rat 4 and  1 integrins showed consistent, low levels of
expression. Although 4 was expressed at lower levels on neutrophils
than all other rat leukocytes, this level of expression was sufficient
to mediate significant levels of 4- and 1-dependent neutrophil
adhesion to rat and human VCAM-1, and 4-dependent, but
1-independent, adhesion to human MAdCAM-1. These data suggest that
rat neutrophils, unlike other species, may use 4 integrins to
traffic to sites of inflammation in vivo.
Blood, Vol. 91 No. 7 (April 1), 1998:
pp. 2341-2346
© 1998 by The American Society of Hematology.
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