|
|
 Previous Article | Table of Contents | Next Article 
Gene Expression by Single Reed-Sternberg Cells: Pathways of
Apoptosis and Activation
Christina Messineo,
M. Hunter Jamerson,
Eileen Hunter,
Rita Braziel,
Adam Bagg,
Steven G. Irving, and
Jeffrey Cossman
From Georgetown University Medical Center, Washington, DC; and Oregon
Health Sciences University, Portland, OR.
Although Hodgkin's disease is highly responsive to treatments that
cause apoptosis, it remains resistant to the physiological mechanisms
intended to cause cell death. Presumably, the Reed-Sternberg cell
defies endogenous apoptosis, persists, accumulates, and manifests the
malignant disorder seen clinically. The Reed-Sternberg cell expresses
several members of the tumor necrosis factor receptor superfamily. This
family of receptors is involved in both activation and proliferation of
cells, as well as either protection from or initiation of apoptosis in
cells expressing these surface proteins. Signals from these receptors
affect transcription. We reasoned that the activation state and
resistance to apoptosis of Reed-Sternberg cells might be attributable
to dysregulation of genes controling these processes. To determine gene
expression by Reed-Sternberg cells, we developed a method of
micromanipulation, global reverse transcription, and the reverse
transcription-polymerase chain reaction and applied it to 51 single
Reed-Sternberg cells and their variants from six cases of Hodgkin's
disease. This report analyzes the gene expression of bcl-xs,
bcl-xl, bax- ,
bax- , fadd, fas, fas
ligand (fas L), ice,
TNF-, TNF-,
TNFR1, TNFR2, TRAF1,
TRAF2, TRAF3, cIAP2, and tradd at the
level of mRNA in the single Reed-Sternberg cells and their variants.
The findings here suggest a molecular mechanism for the activated state
and in vivo survival occurring in untreated Reed-Sternberg cells of Hodgkin's disease.
Blood, Vol. 91 No. 7 (April 1), 1998:
pp. 2443-2451
© 1998 by The American Society of Hematology.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
R. Greil, G. Anether, K. Johrer, and I. Tinhofer
Tracking death dealing by Fas and TRAIL in lymphatic neoplastic disorders: pathways, targets, and therapeutic tools
J. Leukoc. Biol.,
September 1, 2003;
74(3):
311 - 330.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G Siegler, E Kremmer, R Gonnella, and G Niedobitek
Epstein-Barr virus encoded latent membrane protein 1 (LMP1) and TNF receptor associated factors (TRAF): colocalisation of LMP1 and TRAF1 in primary EBV infection and in EBV associated Hodgkin lymphoma
Mol. Pathol.,
June 1, 2003;
56(3):
156 - 161.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. F. Garcia, F. I. Camacho, M. Morente, M. Fraga, C. Montalban, T. A. C. Bellas, A. Castano, A. Diez, T. Flores, C. Martin, et al.
Hodgkin and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: analyses using tissue microarrays
Blood,
January 15, 2003;
101(2):
681 - 689.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. G. Eliopoulos, E. R. Waites, S. M. S. Blake, C. Davies, P. Murray, and L. S. Young
TRAF1 Is a Critical Regulator of JNK Signaling by the TRAF-Binding Domain of the Epstein-Barr Virus-Encoded Latent Infection Membrane Protein 1 but Not CD40
J. Virol.,
December 20, 2002;
77(2):
1316 - 1328.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hinz, P. Lemke, I. Anagnostopoulos, C. Hacker, D. Krappmann, S. Mathas, B. Dorken, M. Zenke, H. Stein, and C. Scheidereit
Nuclear Factor {kappa}B-dependent Gene Expression Profiling of Hodgkin's Disease Tumor Cells, Pathogenetic Significance, and Link to Constitutive Signal Transducer and Activator of Transcription 5a Activity
J. Exp. Med.,
September 2, 2002;
196(5):
605 - 617.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Z. Rassidakis, L. J. Medeiros, T. J. McDonnell, S. Viviani, V. Bonfante, G. Nadali, T. P. Vassilakopoulos, R. Giardini, M. Chilosi, C. Kittas, et al.
BAX Expression in Hodgkin and Reed-Sternberg Cells of Hodgkin's Disease: Correlation with Clinical Outcome
Clin. Cancer Res.,
February 1, 2002;
8(2):
488 - 493.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Aldinucci, D. Poletto, A. Gloghini, P. Nanni, M. Degan, T. Perin, P. Ceolin, F. M. Rossi, V. Gattei, A. Carbone, et al.
Expression of Functional Interleukin-3 Receptors on Hodgkin and Reed-Sternberg Cells
Am. J. Pathol.,
February 1, 2002;
160(2):
585 - 596.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Cossman
Gene Expression Analysis of Single Neoplastic Cells and the Pathogenesis of Hodgkin's Lymphoma
J. Histochem. Cytochem.,
June 1, 2001;
49(6):
799 - 800.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
G. L. Sica, G. Zhu, K. Tamada, D. Liu, J. Ni, and L. Chen
RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-{kappa}B
Blood,
May 1, 2001;
97(9):
2702 - 2707.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hinz, P. Loser, S. Mathas, D. Krappmann, B. Dorken, and C. Scheidereit
Constitutive NF-{kappa}B maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells
Blood,
May 1, 2001;
97(9):
2798 - 2807.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. Annunziata, Y. J. Safiran, S. G. Irving, U. N. Kasid, and J. Cossman
Hodgkin disease: pharmacologic intervention of the CD40-NFkappa B pathway by a protease inhibitor
Blood,
October 15, 2000;
96(8):
2841 - 2848.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. M. Raaphorst, F. J. van Kemenade, T. Blokzijl, E. Fieret, K. M. Hamer, D. P. E. Satijn, A. P. Otte, and C. J. L. M. Meijer
Coexpression of BMI-1 and EZH2 Polycomb Group Genes in Reed-Sternberg Cells of Hodgkin's Disease
Am. J. Pathol.,
September 1, 2000;
157(3):
709 - 715.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. von Wasielewski, S. Seth, J. Franklin, R. Fischer, K. Hubner, M. L. Hansmann, V. Diehl, and A. Georgii
Tissue eosinophilia correlates strongly with poor prognosis in nodular sclerosing Hodgkin's disease, allowing for known prognostic factors
Blood,
February 15, 2000;
95(4):
1207 - 1213.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. R. Taupin, K. Kinoshita, and D. K. Podolsky
Intestinal trefoil factor confers colonic epithelial resistance to apoptosis
PNAS,
January 18, 2000;
97(2):
799 - 804.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. M. Staudt
The Molecular and Cellular Origins of Hodgkin's Disease
J. Exp. Med.,
January 17, 2000;
191(2):
207 - 212.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Cossman, C. M. Annunziata, S. Barash, L. Staudt, P. Dillon, W.-W. He, P. Ricciardi-Castagnoli, C. A. Rosen, and K. C. Carter
Reed-Sternberg Cell Genome Expression Supports a B-Cell Lineage
Blood,
July 15, 1999;
94(2):
411 - 416.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. L. ten Berge, D. F. Dukers, J. J. Oudejans, K. Pulford, G. J. Ossenkoppele, D. de Jong, J. F.M.M. Misere, and C. J.L.M. Meijer
Adverse Effects of Activated Cytotoxic T Lymphocytes on the Clinical Outcome of Nodal Anaplastic Large Cell Lymphoma
Blood,
April 15, 1999;
93(8):
2688 - 2696.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Durkop, H.-D. Foss, G. Demel, H. Klotzbach, C. Hahn, and H. Stein
Tumor Necrosis Factor Receptor-Associated Factor 1 Is Overexpressed in Reed-Sternberg Cells of Hodgkin's Disease and Epstein-Barr Virus-Transformed Lymphoid Cells
Blood,
January 15, 1999;
93(2):
617 - 623.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-Y. Hong, W.-H. Yoon, J.-H. Park, S.-G. Kang, J.-H. Ahn, and T. H. Lee
Involvement of Two NF-kappa B Binding Elements in Tumor Necrosis Factor alpha -, CD40-, and Epstein-Barr Virus Latent Membrane Protein 1-mediated Induction of the Cellular Inhibitor of Apoptosis Protein 2 Gene
J. Biol. Chem.,
June 9, 2000;
275(24):
18022 - 18028.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
