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Identification of a Common Developmental Pathway for Thymic Natural
Killer Cells and Dendritic Cells
Carlos Márquez,
César Trigueros,
Jaime M. Franco,
Almudena R. Ramiro,
Yolanda R. Carrasco,
Miguel López-Botet, and
María L. Toribio
From the Centro de Biología Molecular "Severo Ochoa,"
Universidad Autónoma de Madrid, Madrid, Spain; and the Servicio
de Inmunología, Hospital de la Princesa, Madrid, Spain.
Current data support the notion that the thymus is seeded by a yet
uncommitted progenitor cell able to generate T cells, B cells, natural
killer (NK) cells, and dendritic cells (DCs). We assess in this report
the developmental relationship of DCs and NK cells derived from a small
subset of CD34+ human postnatal thymocytes that, like the
earliest precursors in the fetal thymus, display low CD33 surface
expression. Culture of these isolated CD34+
CD33lo thymic progenitors with a mixture of cytokines,
including interleukin-7 (IL-7), IL-1 , IL-6, granulocyte-macrophage
colony-stimulating factor, and stem cell factor, results in predominant
generation of DCs. However, the addition of IL-2 to the cytokine
mixture leads to the simultaneous development of DCs and NK
cells. Both developmental pathways progress through a transient
population of CD34+CD44bright
CD5lo/ CD33+ large-sized cells,
distinct from small-sized T-lineage precursors, that contain
bipotential NK/DC progenitors. These data provide evidence of linked
pathways of NK cell and DC development from intrathymic precursors and
suggest that NK cells and DCs branch off the T lineage through a common
intermediate progenitor.
Blood, Vol. 91 No. 8 (April 15), 1998:
pp. 2760-2771
© 1998 by The American Society of Hematology.
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