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Inhibition of Eosinophil Rolling and Recruitment in P-Selectin- and
Intracellular Adhesion Molecule-1-Deficient Mice
David H. Broide,
David Humber, and
P. Sriramarao
From the Department of Medicine, University of California, San Diego,
San Diego, CA; and the Laboratory of Immunology and Vascular Biology,
La Jolla Institute for Experimental Medicine, La Jolla, CA.
To determine the relative in vivo importance of endothelial
expressed adhesion molecules to eosinophil rolling, adhesion, and
transmigration, we have induced eosinophilic peritonitis using ragweed
allergen in P-selectin-deficient, intracellular adhesion molecule-1 (ICAM-1)-deficient and control wild-type mice.
Circulating leukocytes visualized by intravital microscopy exhibited
reduced rolling and firm adhesion in P-selectin-deficient mice and
reduced firm adhesion in ICAM-1-deficient mice. Eosinophils exhibited reduced rolling and firm adhesion to endothelium in
P-selectin-deficient mice. Eosinophil recruitment in
P-selectin-deficient mice (~75% inhibition of eosinophil
recruitment) and ICAM-1-deficient mice (~67% inhibition of
eosinophil recruitment) was significantly reduced compared with
wild-type mice. Eosinophil recruitment was not completely inhibited in
P-selectin/ICAM-1 double-mutant mice (eosinophil recruitment inhibited
~62%). However, pretreatment of P-selectin/ICAM-1-deficient mice
with an anti-vascular cell adhesion molecule (VCAM)
antibody induced near complete inhibition of eosinophil recruitment.
Overall, these studies show that eosinophil rolling and firm adhesion
is significantly reduced in P-selectin-deficient mice and that
P-selectin, ICAM-1, and VCAM are important to eosinophil peritoneal
recruitment after ragweed challenge.
Blood, Vol. 91 No. 8 (April 15), 1998:
pp. 2847-2856
© 1998 by The American Society of Hematology.
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