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Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  A Novel Mutant Gene Involved in T-Lymphocyte-Specific Homing Into Peripheral Lymphoid Organs on Mouse Chromosome 4  Hideki Nakano, Shigeyuki Mori, Hiromichi Yonekawa, Hideo Nariuchi, Akio Matsuzawa, and Terutaka Kakiuchi From the Department of Immunology, Toho University School of Medicine, Tokyo, Japan; the Laboratory Animal Research Center and Department of Allergology, Institute of Medical Science, University of Tokyo, Tokyo, Japan; and the Department of Laboratory Animal Science, The Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan. Previously, we have shown a mutant mouse DDD/1 with T-cell-specific homing defect that is regulated by an autosomal recessive gene, plt (paucity of lymph node T cells), and seems to be caused by lymph node (LN) stromal cells. In the present study, immunohistochemical analysis showed unusual distribution of T cells in LN, Peyer's patches (PP), and spleen from plt/plt, probably due to the failure of T cells to migrate from blood into the T-cell zone in LN or PP, or into the spleen white pulp across high endothelial venule or marginal zone, respectively, based on the experiments in which labelled T cells were injected intravenously and detected in the tissues. Analysis of surface L-selectin and CD44 suggested that T cells with memory phenotype, probably from afferent lymphatics, recruit into plt/plt LN. Linkage mapping by simple-sequence length polymorphism of genomic DNA from 190 backcross progenies produced by intercrossing with MSM/Ms, linked plt most closely with D4Mit237, and localized at 24.7 cM from cetromere on chromosome 4. We discuss the possibility that a wild-type gene on plt locus encodes a chemokine inducing T-cell-specific homing into peripheral lymphoid tissues. Blood, Vol. 91 No. 8 (April 15), 1998: pp. 2886-2895 © 1998 by The American Society of Hematology. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Nagatake, S. Fukuyama, D.-Y. Kim, K. Goda, O. Igarashi, S. Sato, T. Nochi, H. Sagara, Y. Yokota, A. M. Jetten, et al. Id2-, ROR{gamma}t-, and LT{beta}R-independent initiation of lymphoid organogenesis in ocular immunity J. Exp. Med., October 26, 2009; 206(11): 2351 - 2364. [Abstract] [Full Text] [PDF] T. Nitta, S. Nitta, Y. Lei, M. Lipp, and Y. Takahama CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens PNAS, October 6, 2009; 106(40): 17129 - 17133. [Abstract] [Full Text] [PDF] T. Kuwabara, F. Ishikawa, T. Yasuda, K. Aritomi, H. Nakano, Y. Tanaka, Y. Okada, M. Lipp, and T. 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Weyand Lymphoid Neogenesis in Rheumatoid Synovitis J. Immunol., July 15, 2001; 167(2): 1072 - 1080. [Abstract] [Full Text] [PDF] G. Chen, P. Shankar, C. Lange, H. Valdez, P. R. Skolnik, L. Wu, N. Manjunath, and J. Lieberman CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection Blood, July 1, 2001; 98(1): 156 - 164. [Abstract] [Full Text] [PDF] C. H. Kim, L. S. Rott, I. Clark-Lewis, D. J. Campbell, L. Wu, and E. C. Butcher Subspecialization of Cxcr5+ T Cells: B Helper Activity Is Focused in a Germinal Center-Localized Subset of Cxcr5+ T Cells J. Exp. Med., June 18, 2001; 193(12): 1373 - 1382. [Abstract] [Full Text] [PDF] R. Abe, S. C. Donnelly, T. Peng, R. Bucala, and C. N. Metz Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites J. Immunol., June 15, 2001; 166(12): 7556 - 7562. [Abstract] [Full Text] [PDF] P. Hjelmström Lymphoid neogenesis: de novo formation of lymphoid tissue in chronic inflammation through expression of homing chemokines J. Leukoc. Biol., March 1, 2001; 69(3): 331 - 339. [Abstract] [Full Text] S. Mori, H. Nakano, K. Aritomi, C.-R. Wang, M. D. Gunn, and T. Kakiuchi Mice Lacking Expression of the Chemokines Ccl21-Ser and Ccl19 (plt Mice) Demonstrate Delayed but Enhanced T Cell Immune Responses J. Exp. Med., January 15, 2001; 193(2): 207 - 218. [Abstract] [Full Text] [PDF] H. Nakano and M. D. Gunn Gene Duplications at the Chemokine Locus on Mouse Chromosome 4: Multiple Strain-Specific Haplotypes and the Deletion of Secondary Lymphoid-Organ Chemokine and EBI-1 Ligand Chemokine Genes in the plt Mutation J. Immunol., January 1, 2001; 166(1): 361 - 369. [Abstract] [Full Text] [PDF] P. Schaerli, K. Willimann, A. B. Lang, M. Lipp, P. Loetscher, and B. Moser Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function J. Exp. Med., December 4, 2000; 192(11): 1553 - 1562. [Abstract] [Full Text] [PDF] S. A. Luther, H. L. Tang, P. L. Hyman, A. G. Farr, and J. G. Cyster Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse PNAS, November 7, 2000; 97(23): 12694 - 12699. [Abstract] [Full Text] [PDF] M.-C. Dieu-Nosjean, C. Massacrier, B. Homey, B. Vanbervliet, J.-J. Pin, A. Vicari, S. Lebecque, C. Dezutter-Dambuyant, D. Schmitt, A. Zlotnik, et al. Macrophage Inflammatory Protein 3{alpha} Is Expressed at Inflamed Epithelial Surfaces and Is the Most Potent Chemokine Known in Attracting Langerhans Cell Precursors J. Exp. Med., September 5, 2000; 192(5): 705 - 718. [Abstract] [Full Text] [PDF] T. M. Engeman, A. V. Gorbachev, R. P. Gladue, P. S. Heeger, and R. L. Fairchild Inhibition of Functional T Cell Priming and Contact Hypersensitivity Responses by Treatment with Anti-Secondary Lymphoid Chemokine Antibody During Hapten Sensitization J. Immunol., May 15, 2000; 164(10): 5207 - 5214. [Abstract] [Full Text] [PDF] A. M. Norment, L. Y. Bogatzki, B. N. Gantner, and M. J. Bevan Murine CCR9, a Chemokine Receptor for Thymus-Expressed Chemokine That Is Up-Regulated Following Pre-TCR Signaling J. Immunol., January 15, 2000; 164(2): 639 - 648. [Abstract] [Full Text] [PDF] J. V. Stein, A. Rot, Y. Luo, M. Narasimhaswamy, H. Nakano, M. D. Gunn, A. Matsuzawa, E. J. Quackenbush, M. E. Dorf, and U. H. von Andrian The Cc Chemokine Thymus-Derived Chemotactic Agent 4 (Tca-4, Secondary Lymphoid Tissue Chemokine, 6ckine, Exodus-2) Triggers Lymphocyte Function-Associated Antigen 1-Mediated Arrest of Rolling T Lymphocytes in Peripheral Lymph Node High Endothelial Venules J. Exp. Med., January 3, 2000; 191(1): 61 - 76. [Abstract] [Full Text] [PDF] J. G. Cyster Chemokines and Cell Migration in Secondary Lymphoid Organs Science, December 10, 1999; 286(5447): 2098 - 2102. [Abstract] [Full Text] G. Vassileva, H. Soto, A. Zlotnik, H. Nakano, T. Kakiuchi, J. A. Hedrick, and S. A. Lira The Reduced Expression of 6ckine in the plt Mouse Results from the Deletion of One of Two 6ckine Genes J. Exp. Med., October 18, 1999; 190(8): 1183 - 1188. [Abstract] [Full Text] [PDF] G. Suzuki, H. Sawa, Y. Kobayashi, Y. Nakata, K.-i. Nakagawa, A. Uzawa, H. Sakiyama, S. Kakinuma, K. Iwabuchi, and K. Nagashima Pertussis Toxin-Sensitive Signal Controls the Trafficking of Thymocytes Across the Corticomedullary Junction in the Thymus J. Immunol., May 15, 1999; 162(10): 5981 - 5985. [Abstract] [Full Text] [PDF] M. D. Gunn, S. Kyuwa, C. Tam, T. Kakiuchi, A. Matsuzawa, L. T. Williams, and H. Nakano Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization J. Exp. Med., February 1, 1999; 189(3): 451 - 460. [Abstract] [Full Text] [PDF] J. G. Cyster Chemokines and the Homing of Dendritic Cells to the T Cell Areas of Lymphoid Organs J. Exp. Med., February 1, 1999; 189(3): 447 - 450. [Full Text] [PDF] K. Uchimura, K. Kadomatsu, H. Nishimura, H. Muramatsu, E. Nakamura, N. Kurosawa, O. Habuchi, F. M. El-Fasakhany, Y. Yoshikai, and T. Muramatsu Functional Analysis of the Chondroitin 6-Sulfotransferase Gene in Relation to Lymphocyte Subpopulations, Brain Development, and Oversulfated Chondroitin Sulfates J. Biol. Chem., January 4, 2002; 277(2): 1443 - 1450. [Abstract] [Full Text] [PDF]

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