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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Youn, B.-S. Articles by Kwon, B. S. Search for Related Content PubMed PubMed Citation Articles by Youn, B.-S. Articles by Kwon, B. S. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Characterization of CK8 and CK8-1: Two Alternatively Spliced Forms of Human -Chemokine, Chemoattractants for Neutrophils, Monocytes, and Lymphocytes, and Potent Agonists at CC Chemokine Receptor 1  Byung-S. Youn, Shang M. Zhang, Hal E. Broxmeyer, Scott Cooper, Kathleen Antol, Malcolm Fraser Jr, and Byoung S. Kwon From the Department of Microbiology and Immunology; the Department of Medicine; and the Walther Oncology Center; Indiana University School of Medicine; and the Walther Cancer Institute, Indianapolis; the Department of Chemistry/Physics, Saint Mary's College, Notre Dame; and the Department of Biological Science, University of Notre Dame, South Bend, IN. Two new members of human -chemokine cDNA were isolated based on structural and functional similarities to human leukotactin-1. One of these clones was identical to the previously isolated human -chemokine, CK8, whereas the other is a splicing variant of CK8, therefore named CK8-1. CK8 was short in 51 nucleotides (17 amino acids) compared with CK8-1. The mature proteins of CK8-1 and CK8 consisted of 116 and 99 amino acids with calculated molecular weights of 12,500 and 10,950, respectively. Both CK8-1 and CK8 were potent agonists at CCR1. These chemokines chemoattracted neutrophils, monocytes, and lymphocytes. They also significantly suppressed colony formation by human bone marrow, granulocyte-macrophage, erythroid, and multipotential progenitor cells stimulated by combinations of growth factors. To our knowledge, this is the first example that an alternative splicing produces two active -chemokines from a single gene. Blood, Vol. 91 No. 9 (May 1), 1998: pp. 3118-3126 © 1998 by The American Society of Hematology. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Z. Miao, B. A. Premack, Z. Wei, Y. Wang, C. Gerard, H. Showell, M. Howard, T. J. Schall, and R. Berahovich Proinflammatory Proteases Liberate a Discrete High-Affinity Functional FPRL1 (CCR12) Ligand from CCL23 J. Immunol., June 1, 2007; 178(11): 7395 - 7404. [Abstract] [Full Text] [PDF] H. Novak, A. Muller, N. Harrer, C. Gunther, J. M. Carballido, and M. 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