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High CD30 Ligand Expression by Epithelial Cells and Hassal's
Corpuscles in the Medulla of Human Thymus
Paola Romagnani,
Francesco Annunziato,
Roberto Manetti,
Carmelo Mavilia,
Laura Lasagni,
Cinzia Manuelli,
Gabriella B. Vannelli,
Vittorio Vanini,
Enrico Maggi,
Cinzia Pupilli, and
Sergio Romagnani
From the Department of Clinical Physiopathology, Endocrinology Unit;
the Institute of Internal Medicine and Immunoallergology; and the
Department of Anatomy, University of Florence; and Apuano Pediatric
Hospital, Massa-Carrara, Italy.
CD30 is a member of tumor necrosis factor (TNF) receptor superfamily
that is expressed by activated T cells in the presence of interleukin-4
(IL-4). Although CD30 can mediate a variety of signals, CD30-deficient
mice have impaired negative selection of T cells, suggesting that at
least in the context of murine thymus, CD30 is a cell death-mediating
molecule. The ligand for CD30 (CD30L) is a membrane-associated
glycoprotein related to TNF, which is known to be expressed mainly by
activated T cells and other leukocytes. However, the nature of
CD30L-expressing cells involved in the interaction with CD30+
thymocytes is unclear. We report here that in postnatal human thymus
the great majority of CD30+ cells are double positive (CD4+CD8+),
activated, IL-4 receptor-expressing T cells which selectively localize
in the medullary areas. Moreover, many medullary epithelial cells and Hassal's corpuscles in the same thymus specimens showed unusually high
expression of CD30L in comparison with other lymphoid or nonlymphoid
tissues. These findings provide additional information on the nature
and localization of CD30+ thymocytes and show that epithelial cells
are the major holder of CD30L in the thymic medulla.
Blood, Vol. 91 No. 9 (May 1), 1998:
pp. 3323-3332
© 1998 by The American Society of Hematology.
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