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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pear, W. S. Articles by Baltimore, D. Search for Related Content PubMed PubMed Citation Articles by Pear, W. S. Articles by Baltimore, D. Related Collections Neoplasia Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, Vol. 92 No. 10 (November 15), 1998: pp. 3780-3792 Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow Warren S. Pear, Juli P. Miller, Lanwei Xu, John C. Pui, Benny Soffer, Robert C. Quackenbush, Ann Marie Pendergast, Roderick Bronson, Jon C. Aster, Martin L. Scott, and David Baltimore From the Department of Pathology and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA; the Department of Internal Medicine (Hematology/Oncology), Pharmacology, and Cancer Biology, Duke University School of Medicine, Durham, NC; the Department of Veterinary Medicine, Tufts University, Boston, MA; the Department of Pathology, Brigham and Women's Hospital, Boston, MA; and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA. Expression of the 210-kD bcr/abl fusion oncoprotein can cause a chronic myelogenous leukemia (CML)-like disease in mice receiving bone marrow cells transduced by bcr/abl-encoding retroviruses. However, previous methods failed to yield this disease at a frequency sufficient enough to allow for its use in the study of CML pathogenesis. To overcome this limitation, we have developed an efficient and reproducible method for inducing a CML-like disease in mice receiving P210 bcr/abl-transduced bone marrow cells. All mice receiving P210 bcr/abl-transduced bone marrow cells succumb to a myeloproliferative disease between 3 and 5 weeks after bone marrow transplantation. The myeloproliferative disease recapitulates many of the hallmarks of human CML and is characterized by high white blood cell counts and extensive extramedullary hematopoiesis in the spleen, liver, bone marrow, and lungs. Use of a retroviral vector coexpressing P210 bcr/abl and green fluorescent protein shows that the vast majority of bcr/abl-expressing cells are myeloid. Analysis of the proviral integration pattern shows that, in some mice, the myeloproliferative disease is clonal. In multiple mice, the CML-like disease has been transplantable, inducing a similar myeloproliferative syndrome within 1 month of transfer to sublethally irradiated syngeneic recipients. The disease in many of these mice has progressed to the development of acute lymphoma/leukemia resembling blast crisis. These results demonstrate that murine CML recapitulates important features of human CML. As such, it should be an excellent model for addressing specific issues relating to the pathogenesis and treatment of this disease. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Antoku and B. J. Mayer Distinct roles for Crk adaptor isoforms in actin reorganization induced by extracellular signals J. Cell Sci., November 15, 2009; 122(22): 4228 - 4238. [Abstract] [Full Text] [PDF] S. P. Fahl, R. B. Crittenden, D. Allman, and T. P. Bender c-Myb Is Required for Pro-B Cell Differentiation J. 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Izon Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals Int. Immunol., December 1, 2007; 19(12): 1421 - 1430. [Abstract] [Full Text] [PDF] T. Dileepan, S. C. Kachlany, N. V. Balashova, J. Patel, and S. K. Maheswaran Human CD18 Is the Functional Receptor for Aggregatibacter actinomycetemcomitans Leukotoxin Infect. Immun., October 1, 2007; 75(10): 4851 - 4856. [Abstract] [Full Text] [PDF] D. O'Carroll, I. Mecklenbrauker, P. P. Das, A. Santana, U. Koenig, A. J. Enright, E. A. Miska, and A. Tarakhovsky A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway Genes & Dev., August 15, 2007; 21(16): 1999 - 2004. [Abstract] [Full Text] [PDF] C. Caslini, Z. Yang, M. El-Osta, T. A. Milne, R. K. Slany, and J. L. Hess Interaction of MLL Amino Terminal Sequences with Menin Is Required for Transformation Cancer Res., August 1, 2007; 67(15): 7275 - 7283. [Abstract] [Full Text] [PDF] S. Chu, L. Li, H. Singh, and R. Bhatia BCR-Tyrosine 177 Plays an Essential Role in Ras and Akt Activation and in Human Hematopoietic Progenitor Transformation in Chronic Myelogenous Leukemia Cancer Res., July 15, 2007; 67(14): 7045 - 7053. [Abstract] [Full Text] [PDF] C. Peng, J. Brain, Y. Hu, A. Goodrich, L. Kong, D. Grayzel, R. Pak, M. Read, and S. Li Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I-induced leukemia and suppresses leukemic stem cells Blood, July 15, 2007; 110(2): 678 - 685. [Abstract] [Full Text] [PDF] M. Yan, J.-K. Luo, K. J. Ritchie, I. Sakai, K. Takeuchi, R. Ren, and D.-E. Zhang Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling Blood, July 1, 2007; 110(1): 305 - 312. [Abstract] [Full Text] [PDF] A. Grande-Garcia, A. Echarri, J. de Rooij, N. B. Alderson, C. M. Waterman-Storer, J. M. Valdivielso, and M. A. del Pozo Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases J. Cell Biol., May 21, 2007; 177(4): 683 - 694. [Abstract] [Full Text] [PDF] R. P. DeKoter, B. L. Schweitzer, M. B. Kamath, D. Jones, H. Tagoh, C. Bonifer, D. A. Hildeman, and K. J. Huang Regulation of the Interleukin-7 Receptor {alpha} Promoter by the Ets Transcription Factors PU.1 and GA-binding Protein in Developing B Cells J. Biol. Chem., May 11, 2007; 282(19): 14194 - 14204. [Abstract] [Full Text] [PDF] M. C. Courreges, D. Burzyn, I. Nepomnaschy, I. Piazzon, and S. R. Ross Critical Role of Dendritic Cells in Mouse Mammary Tumor Virus In Vivo Infection J. Virol., April 15, 2007; 81(8): 3769 - 3777. [Abstract] [Full Text] [PDF] Z. Zou, H. Chen, A. A. Schmaier, R. O. Hynes, and M. L. Kahn Structure-function analysis reveals discrete {beta}3 integrin inside-out and outside-in signaling pathways in platelets Blood, April 15, 2007; 109(8): 3284 - 3290. [Abstract] [Full Text] [PDF] J. L. Roberts, J. P. H. Lauritsen, M. Cooney, R. E. Parrott, E. O. Sajaroff, C. M. Win, M. D. Keller, J. H. Carpenter, J. Carabana, M. S. Krangel, et al. T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3{zeta} subunit of the T-cell antigen receptor complex Blood, April 15, 2007; 109(8): 3198 - 3206. [Abstract] [Full Text] [PDF] X. O. Yang, A. D. Panopoulos, R. Nurieva, S. H. Chang, D. Wang, S. S. Watowich, and C. Dong STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells J. Biol. Chem., March 30, 2007; 282(13): 9358 - 9363. [Abstract] [Full Text] [PDF] A. J. Corbett, C. A. Forbes, D. Moro, and A. A. Scalzo Extensive sequence variation exists among isolates of murine cytomegalovirus within members of the m02 family of genes J. Gen. Virol., March 1, 2007; 88(3): 758 - 769. [Abstract] [Full Text] [PDF] H. M. Kantarjian, F. Giles, A. Quintas-Cardama, and J. Cortes Important Therapeutic Targets in Chronic Myelogenous Leukemia Clin. Cancer Res., February 15, 2007; 13(4): 1089 - 1097. [Abstract] [Full Text] [PDF] S. Taschner, C. Koesters, B. Platzer, A. Jorgl, W. Ellmeier, T. Benesch, and H. Strobl Down-regulation of RXR{alpha} expression is essential for neutrophil development from granulocyte/monocyte progenitors Blood, February 1, 2007; 109(3): 971 - 979. [Abstract] [Full Text] [PDF] V. Jankovic, A. Ciarrocchi, P. Boccuni, T. DeBlasio, R. Benezra, and S. D. Nimer Id1 restrains myeloid commitment, maintaining the self-renewal capacity of hematopoietic stem cells PNAS, January 23, 2007; 104(4): 1260 - 1265. [Abstract] [Full Text] [PDF] J. D. Sherrill and W. E. Miller G Protein-coupled Receptor (GPCR) Kinase 2 Regulates Agonist-independent Gq/11 Signaling from the Mouse Cytomegalovirus GPCR M33 J. Biol. Chem., December 29, 2006; 281(52): 39796 - 39805. [Abstract] [Full Text] [PDF] B. J. Skaggs, M. E. Gorre, A. Ryvkin, M. R. Burgess, Y. Xie, Y. Han, E. Komisopoulou, L. M. Brown, J. A. Loo, E. M. Landaw, et al. Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants PNAS, December 19, 2006; 103(51): 19466 - 19471. [Abstract] [Full Text] [PDF] T. G.P. Bumm, C. Elsea, A. S. Corbin, M. Loriaux, D. Sherbenou, L. Wood, J. Deininger, R. T. Silver, B. J. Druker, and M. W.N. Deininger Characterization of Murine JAK2V617F-Positive Myeloproliferative Disease Cancer Res., December 1, 2006; 66(23): 11156 - 11165. [Abstract] [Full Text] [PDF] S. Ma, A. Turetsky, L. Trinh, and R. Lu IFN Regulatory Factor 4 and 8 Promote Ig Light Chain {kappa} Locus Activation in Pre-B Cell Development J. Immunol., December 1, 2006; 177(11): 7898 - 7904. [Abstract] [Full Text] [PDF] Y. Hu, S. Swerdlow, T. M. Duffy, R. Weinmann, F. Y. Lee, and S. Li Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice PNAS, November 7, 2006; 103(45): 16870 - 16875. [Abstract] [Full Text] [PDF] S. Glaser, D. Metcalf, L. Wu, A. H. Hart, L. DiRago, S. Mifsud, A. D'Amico, S. Dagger, C. Campo, A. C. Chan, et al. Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia PNAS, October 31, 2006; 103(44): 16460 - 16465. [Abstract] [Full Text] [PDF] M. K. Middleton, A. M. Zukas, T. Rubinstein, M. Jacob, P. Zhu, L. Zhao, I. Blair, and E. Pure Identification of 12/15-lipoxygenase as a suppressor of myeloproliferative disease J. Exp. Med., October 30, 2006; 203(11): 2529 - 2540. [Abstract] [Full Text] [PDF] D. D. Kim, T. Miwa, and W.-C. Song Retrovirus-Mediated Over-Expression of Decay-Accelerating Factor Rescues Crry-Deficient Erythrocytes from Acute Alternative Pathway Complement Attack J. Immunol., October 15, 2006; 177(8): 5558 - 5566. [Abstract] [Full Text] [PDF] C. Parikh, R. Subrahmanyam, and R. Ren Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice Blood, October 1, 2006; 108(7): 2349 - 2357. [Abstract] [Full Text] [PDF] F. Abtahian, N. Bezman, R. Clemens, E. Sebzda, L. Cheng, S. J. Shattil, M. L. Kahn, and G. A. Koretzky Evidence for the Requirement of ITAM Domains but Not SLP-76/Gads Interaction for Integrin Signaling in Hematopoietic Cells. Mol. Cell. Biol., September 1, 2006; 26(18): 6936 - 6949. [Abstract] [Full Text] [PDF] B. L. Schweitzer, K. J. Huang, M. B. Kamath, A. V. Emelyanov, B. K. Birshtein, and R. P. DeKoter Spi-C Has Opposing Effects to PU.1 on Gene Expression in Progenitor B Cells J. Immunol., August 15, 2006; 177(4): 2195 - 2207. [Abstract] [Full Text] [PDF] I. J. Griswold, M. MacPartlin, T. Bumm, V. L. Goss, T. O'Hare, K. A. Lee, A. S. Corbin, E. P. Stoffregen, C. Smith, K. Johnson, et al. Kinase domain mutants of bcr-abl exhibit altered transformation potency, kinase activity, and substrate utilization, irrespective of sensitivity to imatinib. Mol. Cell. Biol., August 1, 2006; 26(16): 6082 - 6093. [Abstract] [Full Text] [PDF] K. R. Garrod, C. K. Chang, F.-C. Liu, T. V. Brennan, R. D. Foster, and S.-M. Kang Targeted Lymphoid Homing of Dendritic Cells Is Required for Prolongation of Allograft Survival J. Immunol., July 15, 2006; 177(2): 863 - 868. [Abstract] [Full Text] [PDF] H. T. Ichikawa, M. P. Sowden, A. T. Torelli, J. Bachl, P. Huang, G. S. C. Dance, S. H. Marr, J. Robert, J. E. Wedekind, H. C. Smith, et al. Structural Phylogenetic Analysis of Activation-Induced Deaminase Function J. Immunol., July 1, 2006; 177(1): 355 - 361. [Abstract] [Full Text] [PDF] D. Ye, N. Wolff, L. Li, S. Zhang, and R. L. Ilaria Jr STAT5 signaling is required for the efficient induction and maintenance of CML in mice Blood, June 15, 2006; 107(12): 4917 - 4925. [Abstract] [Full Text] [PDF] S. Gao, H. Wang, P. Lee, J. Melamed, C. X Li, F. Zhang, H. Wu, L. Zhou, and Z. Wang Androgen receptor and prostate apoptosis response factor-4 target the c-FLIP gene to determine survival and apoptosis in the prostate gland. J. Mol. Endocrinol., June 1, 2006; 36(3): 463 - 483. [Abstract] [Full Text] [PDF] C. Guerzoni, M. Bardini, S. A. Mariani, G. Ferrari-Amorotti, P. Neviani, M. L. Panno, Y. Zhang, R. Martinez, D. Perrotti, and B. Calabretta Inducible activation of CEBPB, a gene negatively regulated by BCR/ABL, inhibits proliferation and promotes differentiation of BCR/ABL-expressing cells Blood, May 15, 2006; 107(10): 4080 - 4089. [Abstract] [Full Text] [PDF] H.-G. Wendel, E. de Stanchina, E. Cepero, S. Ray, M. Emig, J. S. Fridman, D. R. Veach, W. G. Bornmann, B. Clarkson, W. R. McCombie, et al. Loss of p53 impedes the antileukemic response to BCR-ABL inhibition PNAS, May 9, 2006; 103(19): 7444 - 7449. [Abstract] [Full Text] [PDF] M. L. Holmes, S. Carotta, L. M. Corcoran, and S. L. Nutt Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment Genes & Dev., April 15, 2006; 20(8): 933 - 938. [Abstract] [Full Text] [PDF] Y. M. Wang, G. Y. Zhang, Y. Wang, M. Hu, H. Wu, D. Watson, S. Hori, I. E. Alexander, D. C.H. Harris, and S. I. Alexander Foxp3-Transduced Polyclonal Regulatory T Cells Protect against Chronic Renal Injury from Adriamycin J. Am. Soc. Nephrol., March 1, 2006; 17(3): 697 - 706. [Abstract] [Full Text] [PDF] M. S. Jordan, J. Sadler, J. E. Austin, L. D. Finkelstein, A. L. Singer, P. L. Schwartzberg, and G. A. Koretzky Functional Hierarchy of the N-Terminal Tyrosines of SLP-76 J. Immunol., February 15, 2006; 176(4): 2430 - 2438. [Abstract] [Full Text] [PDF] W. Cui, J. Z. Ke, Q. Zhang, H.-Z. Ke, C. Chalouni, and A. Vignery The intracellular domain of CD44 promotes the fusion of macrophages Blood, January 15, 2006; 107(2): 796 - 805. [Abstract] [Full Text] [PDF] K. E. Boyd, Y.-Y. Xiao, K. Fan, A. Poholek, N. G. Copeland, N. A. Jenkins, and A. S. Perkins Sox4 cooperates with Evi1 in AKXD-23 myeloid tumors via transactivation of proviral LTR Blood, January 15, 2006; 107(2): 733 - 741. [Abstract] [Full Text] [PDF] A. Dumortier, R. Jeannet, P. Kirstetter, E. Kleinmann, M. Sellars, N. R. dos Santos, C. Thibault, J. Barths, J. Ghysdael, J. A. Punt, et al. Notch Activation Is an Early and Critical Event during T-Cell Leukemogenesis in Ikaros-Deficient Mice Mol. Cell. Biol., January 1, 2006; 26(1): 209 - 220. [Abstract] [Full Text] [PDF] K. Bijangi-Vishehsaraei, M. R. Saadatzadeh, A. Werne, K. A. W. McKenzie, R. Kapur, H. Ichijo, and L. S. Haneline Enhanced TNF-{alpha}-induced apoptosis in Fanconi anemia type C-deficient cells is dependent on apoptosis signal-regulating kinase 1 Blood, December 15, 2005; 106(13): 4124 - 4130. [Abstract] [Full Text] [PDF] P. A. Zweidler-McKay, Y. He, L. Xu, C. G. Rodriguez, F. G. Karnell, A. C. Carpenter, J. C. Aster, D. Allman, and W. S. Pear Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies Blood, December 1, 2005; 106(12): 3898 - 3906. [Abstract] [Full Text] [PDF] D. J. Barnes, D. Palaiologou, E. Panousopoulou, B. Schultheis, A. S.M. Yong, A. Wong, L. Pattacini, J. M. Goldman, and J. V. Melo Bcr-Abl Expression Levels Determine the Rate of Development of Resistance to Imatinib Mesylate in Chronic Myeloid Leukemia Cancer Res., October 1, 2005; 65(19): 8912 - 8919. [Abstract] [Full Text] [PDF] N. Feldhahn, P. Rio, B. N. B. Soh, S. Liedtke, M. Sprangers, F. Klein, P. Wernet, H. Jumaa, W.-K. Hofmann, H. Hanenberg, et al. Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia cells PNAS, September 13, 2005; 102(37): 13266 - 13271. [Abstract] [Full Text] [PDF] F. Corradini, V. Cesi, V. Bartella, E. Pani, R. Bussolari, O. Candini, and B. Calabretta Enhanced Proliferative Potential of Hematopoietic Cells Expressing Degradation-resistant c-Myb Mutants J. Biol. Chem., August 26, 2005; 280(34): 30254 - 30262. [Abstract] [Full Text] [PDF] T. Dileepan, M. S. Kannan, B. Walcheck, P. Thumbikat, and S. K. Maheswaran Mapping of the Binding Site for Mannheimia haemolytica Leukotoxin within Bovine CD18 Infect. Immun., August 1, 2005; 73(8): 5233 - 5237. [Abstract] [Full Text] [PDF] M. Terme, C. Borg, F. Guilhot, C. Masurier, C. Flament, E. F. Wagner, S. Caillat-Zucman, A. Bernheim, A. G. Turhan, A. Caignard, et al. BCR/ABL Promotes Dendritic Cell-Mediated Natural Killer Cell Activation Cancer Res., July 15, 2005; 65(14): 6409 - 6417. [Abstract] [Full Text] [PDF] R. Grundler, C. Miething, C. Thiede, C. Peschel, and J. Duyster FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model Blood, June 15, 2005; 105(12): 4792 - 4799. [Abstract] [Full Text] [PDF] N. Feldhahn, F. Klein, J. L. Mooster, P. Hadweh, M. Sprangers, M. Wartenberg, M. M. Bekhite, W.-K. Hofmann, S. Herzog, H. Jumaa, et al. Mimicry of a constitutively active pre-B cell receptor in acute lymphoblastic leukemia cells J. Exp. Med., June 6, 2005; 201(11): 1837 - 1852. [Abstract] [Full Text] [PDF] J. Cho, M. Melnick, G. P. Solidakis, and P. N. Tsichlis Tpl2 (Tumor Progression Locus 2) Phosphorylation at Thr290 Is Induced by Lipopolysaccharide via an I{kappa}-B Kinase-{beta}-dependent Pathway and Is Required for Tpl2 Activation by External Signals J. Biol. Chem., May 27, 2005; 280(21): 20442 - 20448. [Abstract] [Full Text] [PDF] N. C. Wolff, D. R. Veach, W. P. Tong, W. G. Bornmann, B. Clarkson, and R. L. Ilaria Jr PD166326, a novel tyrosine kinase inhibitor, has greater antileukemic activity than imatinib mesylate in a murine model of chronic myeloid leukemia Blood, May 15, 2005; 105(10): 3995 - 4003. [Abstract] [Full Text] [PDF] A. Quintas-Cardama, H. Kantarjian, M. Talpaz, S. O'Brien, G. Garcia-Manero, S. Verstovsek, M. B. Rios, K. Hayes, A. Glassman, B. N. Bekele, et al. Imatinib mesylate therapy may overcome the poor prognostic significance of deletions of derivative chromosome 9 in patients with chronic myelogenous leukemia Blood, March 15, 2005; 105(6): 2281 - 2286. [Abstract] [Full Text] [PDF] W. Tang, Y. Li, D. Yu, A. Thomas-Tikhonenko, V. S. Spiegelman, and S. Y. Fuchs Targeting {beta}-Transducin Repeat-Containing Protein E3 Ubiquitin Ligase Augments the Effects of Antitumor Drugs on Breast Cancer Cells Cancer Res., March 1, 2005; 65(5): 1904 - 1908. [Abstract] [Full Text] [PDF] L. ZENDER, W. XUE, C. CORDON-CARDO, G.J. HANNON, R. LUCITO, S. POWERS, P. FLEMMING, M.S. SPECTOR, and S.W. LOWE Generation and Analysis of Genetically Defined Liver Carcinomas Derived from Bipotential Liver Progenitors Cold Spring Harb Symp Quant Biol, January 1, 2005; 70(0): 251 - 261. [Abstract] [PDF] S. Koschmieder, B. Gottgens, P. Zhang, J. Iwasaki-Arai, K. Akashi, J. L. Kutok, T. Dayaram, K. Geary, A. R. Green, D. G. Tenen, et al. Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis Blood, January 1, 2005; 105(1): 324 - 334. [Abstract] [Full Text] [PDF] K. W. Harder, C. Quilici, E. Naik, M. Inglese, N. Kountouri, A. Turner, K. Zlatic, D. M. Tarlinton, and M. L. Hibbs Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1 Blood, December 15, 2004; 104(13): 3901 - 3910. [Abstract] [Full Text] [PDF] K. W. H. Yee, M. Schittenhelm, A.-M. O'Farrell, A. R. Town, L. McGreevey, T. Bainbridge, J. M. Cherrington, and M. C. Heinrich Synergistic effect of SU11248 with cytarabine or daunorubicin on FLT3 ITD-positive leukemic cells Blood, December 15, 2004; 104(13): 4202 - 4209. [Abstract] [Full Text] [PDF] S. Wong, J. McLaughlin, D. Cheng, C. Zhang, K. M. Shokat, and O. N. Witte Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations PNAS, December 14, 2004; 101(50): 17456 - 17461. [Abstract] [Full Text] [PDF] J. C. Nixon, J. Rajaiya, and C. F. Webb Mutations in the DNA-binding Domain of the Transcription Factor Bright Act as Dominant Negative Proteins and Interfere with Immunoglobulin Transactivation J. Biol. Chem., December 10, 2004; 279(50): 52465 - 52472. [Abstract] [Full Text] [PDF] M. Yan, S. A. Burel, L. F. Peterson, E. Kanbe, H. Iwasaki, A. Boyapati, R. Hines, K. Akashi, and D.-E. Zhang From the Cover: Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development PNAS, December 7, 2004; 101(49): 17186 - 17191. [Abstract] [Full Text] [PDF] P. B. Deming, Z. T. Schafer, J. S. Tashker, M. B. Potts, M. Deshmukh, and S. Kornbluth Bcr-Abl-Mediated Protection from Apoptosis Downstream of Mitochondrial Cytochrome c Release Mol. Cell. Biol., December 1, 2004; 24(23): 10289 - 10299. [Abstract] [Full Text] [PDF] M. S. Ricci, Z. Jin, M. Dews, D. Yu, A. Thomas-Tikhonenko, D. T. Dicker, and W. S. El-Deiry Direct Repression of FLIP Expression by c-myc Is a Major Determinant of TRAIL Sensitivity Mol. Cell. Biol., October 1, 2004; 24(19): 8541 - 8555. [Abstract] [Full Text] [PDF] S. Guo, G. Z. Ferl, R. Deora, M. Riedinger, S. Yin, J. L. Kerwin, J. A. Loo, and O. N. Witte A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-{gamma} activation PNAS, September 28, 2004; 101(39): 14180 - 14185. [Abstract] [Full Text] [PDF] P. Ramaraj, H. Singh, N. Niu, S. Chu, M. Holtz, J. K. Yee, and R. Bhatia Effect of Mutational Inactivation of Tyrosine Kinase Activity on BCR/ABL-Induced Abnormalities in Cell Growth and Adhesion in Human Hematopoietic Progenitors Cancer Res., August 1, 2004; 64(15): 5322 - 5331. [Abstract] [Full Text] [PDF]

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