Blood, Vol. 92 No. 11 (December 1), 1998:
pp. 4079-4079
PHOTOGRAPH
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Alveolar cell carcinoma of the lung. A 52-year-old woman smoker
with a history of breast carcinoma 6 years earlier was evaluated for a
single lung nodule. Light microscopy showed a bronchiolo-alveolar
growth pattern of an adenocarcinoma which did not resemble the earlier
breast carcinoma in breast or axillary lymph nodes. Electron microscopy
was diagnostic for alveolar cell carcinoma. The tumor cells formed
glands and were filled with lamellar bodies, often referred to as
surfactant bodies. These secretory granules are diagnostic for
adenocarcinoma cells of type II alveolar pneumocyte origin in primary
and metastatic tumor sites. Original magnification ×13,000. (Courtesy
of Ann M. Dvorak, MD, Department of Pathology, Beth Israel Deaconess
Medical Center, Harvard Medical School, Boston, MA.)
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