|
|
 Previous Article | Table of Contents | Next Article 
Evidence for Circulating Bone Marrow-Derived Endothelial Cells
Qun Shi,
Shahin Rafii,
Moses Hong-De Wu,
Errol S. Wijelath,
Cong Yu,
Atsushi Ishida,
Yuji Fujita,
Sudesh Kothari,
Robert Mohle,
Lester R. Sauvage,
Malcom A.S. Moore,
Rainer F. Storb, and
William
P. Hammond
From the Departments of Surgery and Molecular Biology, The Hope Heart
Institute and Providence Medical Center, Seattle, WA; the
Hematology-Oncology Division, Cornell Medical College, New York, NY;
the Fred Hutchinson Cancer Research Center, Seattle, WA; the
Sloan-Kettering Cancer Research Center, New York, NY; and the
Departments of Surgery and Medicine, University of Washington School of
Medicine, Seattle, WA.
It has been proposed that hematopoietic and endothelial cells are
derived from a common cell, the hemangioblast. In this study, we
demonstrate that a subset of CD34+ cells have the
capacity to differentiate into endothelial cells in vitro in the
presence of basic fibroblast growth factor, insulin-like growth
factor-1, and vascular endothelial growth factor. These differentiated
endothelial cells are CD34+, stain for von Willebrand
factor (vWF), and incorporate acetylated low-density lipoprotein
(LDL). This suggests the possible existence of a bone
marrow-derived precursor endothelial cell. To demonstrate this
phenomenon in vivo, we used a canine bone marrow transplantation model,
in which the marrow cells from the donor and recipient are genetically
distinct. Between 6 to 8 months after transplantation, a Dacron graft,
made impervious to prevent capillary ingrowth from the surrounding
perigraft tissue, was implanted in the descending thoracic aorta. After
12 weeks, the graft was retrieved, and cells with endothelial
morphology were identified by silver nitrate staining. Using the
di(CA)n and tetranucleotide (GAAA)n repeat polymorphisms to distinguish between the donor and recipient DNA, we
observed that only donor alleles were detected in DNA from positively
stained cells on the impervious Dacron graft. These results strongly
suggest that a subset of CD34+ cells localized in the
bone marrow can be mobilized to the peripheral circulation and can
colonize endothelial flow surfaces of vascular prostheses.
Blood, Vol. 92 No. 2 (July 15), 1998:
pp. 362-367
© 1998 by the American Society of Hematology.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
A. M. van Rij, G. T. Jones, B. G. Hill, M. Amer, I. A. Thomson, R. A. Pettigrew, and S. G.K. Packer
Mechanical Inhibition of Angiogenesis at the Saphenofemoral Junction in the Surgical Treatment of Varicose Veins: Early Results of a Blinded Randomized Controlled Trial
Circulation,
July 1, 2008;
118(1):
66 - 74.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Povsic and P. J. Goldschmidt-Clermont
Review: Endothelial progenitor cells: markers of vascular reparative capacity
Therapeutic Advances in Cardiovascular Disease,
June 1, 2008;
2(3):
199 - 213.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. Hinkel, C. El-Aouni, T. Olson, J. Horstkotte, S. Mayer, S. Muller;, M. Willhauck, C. Spitzweg, F.-J. Gildehaus, W. Munzing, et al.
Thymosin {beta}4 Is an Essential Paracrine Factor of Embryonic Endothelial Progenitor Cell-Mediated Cardioprotection
Circulation,
April 29, 2008;
117(17):
2232 - 2240.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Chavakis, G. Carmona, C. Urbich, S. Gottig, R. Henschler, J. M. Penninger, A. M. Zeiher, T. Chavakis, and S. Dimmeler
Phosphatidylinositol-3-Kinase-{gamma} Is Integral to Homing Functions of Progenitor Cells
Circ. Res.,
April 25, 2008;
102(8):
942 - 949.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Yao, Z.-H. Liu, C. Zheng, X. Zhang, H. Chen, C. Zeng, and L.-S. Li
Evaluation of renal vascular lesions using circulating endothelial cells in patients with lupus nephritis
Rheumatology,
April 1, 2008;
47(4):
432 - 436.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Carmona, E. Chavakis, U. Koehl, A. M. Zeiher, and S. Dimmeler
Activation of Epac stimulates integrin-dependent homing of progenitor cells
Blood,
March 1, 2008;
111(5):
2640 - 2646.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. C. Rafii, B. Psaila, J. Butler, D. K. Jin, and D. Lyden
Regulation of Vasculogenesis by Platelet-Mediated Recruitment of Bone Marrow-Derived Cells
Arterioscler. Thromb. Vasc. Biol.,
February 1, 2008;
28(2):
217 - 222.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Zoll, V. Fontaine, P. Gourdy, V. Barateau, J. Vilar, A. Leroyer, I. Lopes-Kam, Z. Mallat, J.-F. Arnal, P. Henry, et al.
Role of human smooth muscle cell progenitors in atherosclerotic plaque development and composition
Cardiovasc Res,
February 1, 2008;
77(3):
471 - 480.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-J. Cho, N. Lee, J. Y. Lee, Y. J. Choi, M. Ii, A. Wecker, J.-O. Jeong, C. Curry, G. Qin, and Y.-s. Yoon
Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart
J. Exp. Med.,
December 24, 2007;
204(13):
3257 - 3269.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Kanayasu-Toyoda, A. Ishii-Watabe, T. Suzuki, T. Oshizawa, and T. Yamaguchi
A New Role of Thrombopoietin Enhancing ex Vivo Expansion of Endothelial Precursor Cells Derived from AC133-positive Cells
J. Biol. Chem.,
November 16, 2007;
282(46):
33507 - 33514.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Tongers and D. W. Losordo
Frontiers in Nephrology: The Evolving Therapeutic Applications of Endothelial Progenitor Cells
J. Am. Soc. Nephrol.,
November 1, 2007;
18(11):
2843 - 2852.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Y. Sheikh, S.-A. Lin, F. Cao, Y. Cao, K. E.A. van der Bogt, P. Chu, C.-P. Chang, C. H. Contag, R. C. Robbins, and J. C. Wu
Molecular Imaging of Bone Marrow Mononuclear Cell Homing and Engraftment in Ischemic Myocardium
Stem Cells,
October 1, 2007;
25(10):
2677 - 2684.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Li, P. Atmaca-Sonmez, C. L. Schanie, S. T. Ildstad, H. J. Kaplan, and V. Enzmann
Endogenous Bone Marrow Derived Cells Express Retinal Pigment Epithelium Cell Markers and Migrate to Focal Areas of RPE Damage
Invest. Ophthalmol. Vis. Sci.,
September 1, 2007;
48(9):
4321 - 4327.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. D. Hauer, G. H.M. van Puijvelde, N. Peterse, P. de Vos, V. van Weel, E. J.A. van Wanrooij, E. A.L. Biessen, P. H.A. Quax, A. G. Niethammer, R. A. Reisfeld, et al.
Vaccination Against VEGFR2 Attenuates Initiation and Progression of Atherosclerosis
Arterioscler. Thromb. Vasc. Biol.,
September 1, 2007;
27(9):
2050 - 2057.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Levenberg, J. Zoldan, Y. Basevitch, and R. Langer
Endothelial potential of human embryonic stem cells
Blood,
August 1, 2007;
110(3):
806 - 814.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Y. Liu, D. D. Swartz, H. F. Peng, S. F. Gugino, J. A. Russell, and S. T. Andreadis
Functional tissue-engineered blood vessels from bone marrow progenitor cells
Cardiovasc Res,
August 1, 2007;
75(3):
618 - 628.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Schmidt, K. Brixius, and W. Bloch
Endothelial Precursor Cell Migration During Vasculogenesis
Circ. Res.,
July 20, 2007;
101(2):
125 - 136.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Timmermans, F. Van Hauwermeiren, M. De Smedt, R. Raedt, F. Plasschaert, M. L. De Buyzere, T. C. Gillebert, J. Plum, and B. Vandekerckhove
Endothelial Outgrowth Cells Are Not Derived From CD133+ Cells or CD45+ Hematopoietic Precursors
Arterioscler. Thromb. Vasc. Biol.,
July 1, 2007;
27(7):
1572 - 1579.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Nagano, T. Yamashita, H. Hamada, K. Ohneda, K.-i. Kimura, T. Nakagawa, M. Shibuya, H. Yoshikawa, and O. Ohneda
Identification of functional endothelial progenitor cells suitable for the treatment of ischemic tissue using human umbilical cord blood
Blood,
July 1, 2007;
110(1):
151 - 160.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. K. Kissel, R. Lehmann, B. Assmus, A. Aicher, J. Honold, U. Fischer-Rasokat, C. Heeschen, I. Spyridopoulos, S. Dimmeler, and A. M. Zeiher
Selective Functional Exhaustion of Hematopoietic Progenitor Cells in the Bone Marrow of Patients With Postinfarction Heart Failure
J. Am. Coll. Cardiol.,
June 19, 2007;
49(24):
2341 - 2349.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Invernici, C. Emanueli, P. Madeddu, S. Cristini, S. Gadau, A. Benetti, E. Ciusani, G. Stassi, M. Siragusa, R. Nicosia, et al.
Human Fetal Aorta Contains Vascular Progenitor Cells Capable of Inducing Vasculogenesis, Angiogenesis, and Myogenesis in Vitro and in a Murine Model of Peripheral Ischemia
Am. J. Pathol.,
June 1, 2007;
170(6):
1879 - 1892.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Melero-Martin, Z. A. Khan, A. Picard, X. Wu, S. Paruchuri, and J. Bischoff
In vivo vasculogenic potential of human blood-derived endothelial progenitor cells
Blood,
June 1, 2007;
109(11):
4761 - 4768.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-K. Oh, J.-M. Ha, E. O, B. H. Lee, S. K. Lee, B.-S. Shim, Y.-K. Hong, and Y. A. Joe
Tumor Angiogenesis Promoted by Ex vivo Differentiated Endothelial Progenitor Cells Is Effectively Inhibited by an Angiogenesis Inhibitor, TK1-2
Cancer Res.,
May 15, 2007;
67(10):
4851 - 4859.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Schwartzenberg, V. Deutsch, S. Maysel-Auslender, S. Kissil, G. Keren, and J. George
Circulating Apoptotic Progenitor Cells: A Novel Biomarker in Patients With Acute Coronary Syndromes
Arterioscler. Thromb. Vasc. Biol.,
May 1, 2007;
27(5):
e27 - e31.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. L.T. Ballard and J. M. Edelberg
Stem Cells and the Regeneration of the Aging Cardiovascular System
Circ. Res.,
April 27, 2007;
100(8):
1116 - 1127.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Caballero, N. Sengupta, A. Afzal, K.-H. Chang, S. Li Calzi, D. L. Guberski, T. S. Kern, and M. B. Grant
Ischemic Vascular Damage Can Be Repaired by Healthy, but Not Diabetic, Endothelial Progenitor Cells
Diabetes,
April 1, 2007;
56(4):
960 - 967.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Sigler and C. Jux
Biocompatibility of septal defect closure devices
Heart,
April 1, 2007;
93(4):
444 - 449.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Murata, A. Janin, C. Leboeuf, J. Soulier, E. Gluckman, V. Meignin, and G. Socie
Donor-derived cells and human graft-versus-host disease of the skin
Blood,
March 15, 2007;
109(6):
2663 - 2665.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Aicher, M. Rentsch, K.-i. Sasaki, J. W. Ellwart, F. Fandrich, R. Siebert, J. P. Cooke, S. Dimmeler, and C. Heeschen
Nonbone Marrow-Derived Circulating Progenitor Cells Contribute to Postnatal Neovascularization Following Tissue Ischemia
Circ. Res.,
March 2, 2007;
100(4):
581 - 589.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Zhou, F. X. Ma, P. X. Liu, Z. H. Fang, S. L. Wang, Z. B. Han, M.-C. Poon, and Z. C. Han
Impaired therapeutic vasculogenesis by transplantation of OxLDL-treated endothelial progenitor cells
J. Lipid Res.,
March 1, 2007;
48(3):
518 - 527.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Nishiwaki, M. Yoshida, H. Iwaguro, H. Masuda, N. Nitta, T. Asahara, and M. Isobe
Endothelial E-Selectin Potentiates Neovascularization via Endothelial Progenitor Cell-Dependent and -Independent Mechanisms
Arterioscler. Thromb. Vasc. Biol.,
March 1, 2007;
27(3):
512 - 518.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Chavakis, A. Hain, M. Vinci, G. Carmona, M. E. Bianchi, P. Vajkoczy, A. M. Zeiher, T. Chavakis, and S. Dimmeler
High-Mobility Group Box 1 Activates Integrin-Dependent Homing of Endothelial Progenitor Cells
Circ. Res.,
February 2, 2007;
100(2):
204 - 212.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Chen, H. Bai, Y. Shao, M. Arzigian, V. Janzen, E. Attar, Y. Xie, D. T. Scadden, and Z. Z. Wang
Stromal Cell-Derived Factor-1/CXCR4 Signaling Modifies the Capillary-Like Organization of Human Embryonic Stem Cell-Derived Endothelium In Vitro
Stem Cells,
February 1, 2007;
25(2):
392 - 401.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Sahara, M. Sata, T. Morita, K. Nakamura, Y. Hirata, and R. Nagai
Diverse Contribution of Bone Marrow Derived Cells to Vascular Remodeling Associated With Pulmonary Arterial Hypertension and Arterial Neointimal Formation
Circulation,
January 30, 2007;
115(4):
509 - 517.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. O Robb, N. L Mills, D. E Newby, and F. C Denison
Endothelial progenitor cells in pregnancy
Reproduction,
January 1, 2007;
133(1):
1 - 9.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. C. Schatteman, M. Dunnwald, and C. Jiao
Biology of bone marrow-derived endothelial cell precursors
Am J Physiol Heart Circ Physiol,
January 1, 2007;
292(1):
H1 - H18.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Heeschen, E. Chang, A. Aicher, and J. P. Cooke
Endothelial Progenitor Cells Participate in Nicotine-Mediated Angiogenesis
J. Am. Coll. Cardiol.,
December 19, 2006;
48(12):
2553 - 2560.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Miyamoto, K. Nishigami, N. Nagaya, K. Akutsu, M. Chiku, M. Kamei, T. Soma, S. Miyata, M. Higashi, R. Tanaka, et al.
Unblinded Pilot Study of Autologous Transplantation of Bone Marrow Mononuclear Cells in Patients With Thromboangiitis Obliterans
Circulation,
December 12, 2006;
114(24):
2679 - 2684.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Bonaros, R. Rauf, D. Wolf, E. Margreiter, A. Tzankov, B. Schlechta, A. Kocher, H. Ott, T. Schachner, S. Hering, et al.
Combined transplantation of skeletal myoblasts and angiopoietic progenitor cells reduces infarct size and apoptosis and improves cardiac function in chronic ischemic heart failure
J. Thorac. Cardiovasc. Surg.,
December 1, 2006;
132(6):
1321 - 1328.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Hamada, M. K. Kim, A. Iwakura, M. Ii, T. Thorne, G. Qin, J. Asai, Y. Tsutsumi, H. Sekiguchi, M. Silver, et al.
Estrogen Receptors {alpha} and {beta} Mediate Contribution of Bone Marrow-Derived Endothelial Progenitor Cells to Functional Recovery After Myocardial Infarction
Circulation,
November 21, 2006;
114(21):
2261 - 2270.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Vickers, S. J. Canning, W. L. Craig, N. M. Masson, and I. J. Wilson
X Inactivation Patterns of Closely, but Not Distantly, Related Cells Are Highly Correlated: Little Evidence for Stem Cell Plasticity in Normal Females
Stem Cells,
November 1, 2006;
24(11):
2398 - 2405.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Guven, R. M. Shepherd, R. G. Bach, B. J. Capoccia, and D. C. Link
The Number of Endothelial Progenitor Cell Colonies in the Blood Is Increased in Patients With Angiographically Significant Coronary Artery Disease
J. Am. Coll. Cardiol.,
October 17, 2006;
48(8):
1579 - 1587.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
