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Blood Dendritic Cells From Myeloma Patients Are Not Infected With
Kaposi's Sarcoma-Associated Herpesvirus (KSHV/HHV-8)
Qing Yi,
Marianne Ekman,
Doina Anton,
Susanne Bergenbrant,
Anders Österborg,
Patrik Georgii-Hemming,
Göran Holm,
Kenneth Nilsson, and
Peter Biberfeld
From the Immunological Research Laboratory and Department of
Medicine, the Department of Oncology, and the Division of
Immunopathology, Karolinska Hospital, Stockholm, Sweden; and the
Department of Pathology, University Hospital, Uppsala, Sweden.
In recent studies, the sequence of Kaposi's sarcoma-associated
herpes virus (KSHV) or human herpes virus-8 (HHV-8) was detected in
dendritic cells (DC) of patients with multiple myeloma (MM). A concern
was raised whether there is an causal association between the viral
infection and development of these tumors. In the present study, we
have examined DC generated from blood adherent cells from 8 Swedish MM
patients at different clinical stages and 2 patients with monoclonal
gammopathy of undetermined significance. In addition, 6 myeloma cell
lines and bone marrow cells from 2 MM patients were also studied. By
polymerase chain reaction (PCR), including nested PCR, no virus DNA was
demonstrable in the patients' DC or in myeloma cell lines or fresh
bone marrow cells. Moreover, no antibody against KSHV was found in the
serum of these 10 patients. Thus, our results indicate that
blood-derived DC of MM patients in Sweden usually are not infected with
KSHV/HHV-8. This study also suggests that KSHV/HHV-8 is not regularly
associated with MM and consequently does not play a primary role in the
pathogenesis of these tumors.
Blood, Vol. 92 No. 2 (July 15), 1998:
pp. 402-404
© 1998 by the American Society of Hematology.
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