|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 92 No. 3 (August 1), 1998:
pp. 894-900
Role of Adhesion Molecules in the Homing and Mobilization of Murine
Hematopoietic Stem and Progenitor Cells
Monica Vermeulen,
Françoise Le Pesteur,
Marie-Claude Gagnerault,
Jean-Yves Mary,
Françoise Sainteny, and
Françoise Lepault
From the CNRS URA 1461, Université Paris V, Hôpital
Necker, Paris; INSERM U 362, Institut Gustave Roussy, Villejuif; and
INSERM U 444, Faculté de Médecine Saint Antoine, Paris,
France.
Bone marrow (BM) transplantation still must overcome multiple
difficulties and should benefit from better understanding of stem-cell
homing and mobilization. Here, we analyzed the involvement of several
adhesion molecules in the two processes by treating mice with
monoclonal antibodies against these molecules. Treatment of lethally
irradiated mice grafted with isogeneic BM cells showed that at least
two migration pathways are important for stem-cell homing to the BM,
whereas only one of them is involved in lodging of colony-forming
unit-spleen (CFU-S) in the spleen. We confirm that the VLA-4/VCAM-1
adhesion pathway is important for stem-cell homing to the BM only and
show that CD44 is involved in CFU-S lodging in both BM and spleen.
These results show that entry of CFU-S into the spleen is regulated.
The observation that when one migration pathway is altered, CFU-S do
not enter the BM via the other pathway may indicate that the two
mechanisms involved in CFU-S homing into the BM are linked. The
adhesion molecules VLA-4 and CD44 are also implied in the mobilization
of stem cells into the blood stream of mice injected once with
anti-VLA-4 or anti-CD44. Anti-VLA-4 administration led to a
significant increase in circulating stem cells as early as 8 hours
after treatment. Stem cells mobilized by anti-VLA-4 comprise cells
with high self-renewal potential and thus may be used for long-term
reconstitution of the hematopoietic tissue.
© 1998 by The American Society of Hematology.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
F. Zemani, J.-S. Silvestre, F. Fauvel-Lafeve, A. Bruel, J. Vilar, I. Bieche, I. Laurendeau, I. Galy-Fauroux, A. M. Fischer, and C. Boisson-Vidal
Ex Vivo Priming of Endothelial Progenitor Cells With SDF-1 Before Transplantation Could Increase Their Proangiogenic Potential
Arterioscler Thromb Vasc Biol,
April 1, 2008;
28(4):
644 - 650.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. P. Daley, S. B. Peters, and M. Larsen
Extracellular matrix dynamics in development and regenerative medicine
J. Cell Sci.,
February 1, 2008;
121(3):
255 - 264.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Fukuda, H. Bian, A. G. King, and L. M. Pelus
The chemokine GRO{beta} mobilizes early hematopoietic stem cells characterized by enhanced homing and engraftment
Blood,
August 1, 2007;
110(3):
860 - 869.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kikuchi and M. Kondo
Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth
PNAS,
November 21, 2006;
103(47):
17852 - 17857.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Selleri, P. Ragno, P. Ricci, V. Visconte, N. Scarpato, M. V. Carriero, B. Rotoli, G. Rossi, and N. Montuori
The metastasis-associated 67-kDa laminin receptor is involved in G-CSF-induced hematopoietic stem cell mobilization
Blood,
October 1, 2006;
108(7):
2476 - 2484.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Gribi, L. Hook, J. Ure, and A. Medvinsky
The differentiation program of embryonic definitive hematopoietic stem cells is largely {alpha}4 integrin independent
Blood,
July 15, 2006;
108(2):
501 - 509.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Desponts, A. L. Hazen, K. H. T. Paraiso, and W. G. Kerr
SHIP deficiency enhances HSC proliferation and survival but compromises homing and repopulation
Blood,
June 1, 2006;
107(11):
4338 - 4345.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Qian, K. Tryggvason, S. E. Jacobsen, and M. Ekblom
Contribution of {alpha}6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with {alpha}4 integrins
Blood,
May 1, 2006;
107(9):
3503 - 3510.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Takizawa, C. Kubo-Akashi, I. Nobuhisa, S.-M. Kwon, M. Iseki, T. Taga, K. Takatsu, and S. Takaki
Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk
Blood,
April 1, 2006;
107(7):
2968 - 2975.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Qin, M. Ii, M. Silver, A. Wecker, E. Bord, H. Ma, M. Gavin, D. A. Goukassian, Y.-s. Yoon, T. Papayannopoulou, et al.
Functional disruption of {alpha}4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization
J. Exp. Med.,
January 23, 2006;
203(1):
153 - 163.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Hidalgo and P. S. Frenette
Enforced fucosylation of neonatal CD34+ cells generates selectin ligands that enhance the initial interactions with microvessels but not homing to bone marrow
Blood,
January 15, 2005;
105(2):
567 - 575.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Abbott, Y. Huang, D. Liu, R. Hickey, D. S. Krause, and F. J. Giordano
Stromal Cell-Derived Factor-1{alpha} Plays a Critical Role in Stem Cell Recruitment to the Heart After Myocardial Infarction but Is Not Sufficient to Induce Homing in the Absence of Injury
Circulation,
November 23, 2004;
110(21):
3300 - 3305.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Katayama, A. Hidalgo, A. Peired, and P. S. Frenette
Integrin {alpha}4{beta}7 and its counterreceptor MAdCAM-1 contribute to hematopoietic progenitor recruitment into bone marrow following transplantation
Blood,
October 1, 2004;
104(7):
2020 - 2026.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Avigdor, P. Goichberg, S. Shivtiel, A. Dar, A. Peled, S. Samira, O. Kollet, R. Hershkoviz, R. Alon, I. Hardan, et al.
CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow
Blood,
April 15, 2004;
103(8):
2981 - 2989.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Vroon, C. J. Heijnen, R. Raatgever, I. P. Touw, R. E. Ploemacher, R. T. Premont, and A. Kavelaars
GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivo
J. Leukoc. Biol.,
April 1, 2004;
75(4):
698 - 704.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. M. Scott, G. V. Priestley, and T. Papayannopoulou
Deletion of {alpha}4 Integrins from Adult Hematopoietic Cells Reveals Roles in Homeostasis, Regeneration, and Homing
Mol. Cell. Biol.,
December 15, 2003;
23(24):
9349 - 9360.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Katayama, A. Hidalgo, B. C. Furie, D. Vestweber, B. Furie, and P. S. Frenette
PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow: evidence for cooperation between E-selectin ligands and {alpha}4 integrin
Blood,
September 15, 2003;
102(6):
2060 - 2067.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. Plett, S. M. Frankovitz, and C. M. Orschell
Distribution of marrow repopulating cells between bone marrow and spleen early after transplantation
Blood,
September 15, 2003;
102(6):
2285 - 2291.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. Plett, S. M. Frankovitz, and C. M. Orschell-Traycoff
In vivo trafficking, cell cycle activity, and engraftment potential of phenotypically defined primitive hematopoietic cells after transplantation into irradiated or nonirradiated recipients
Blood,
November 15, 2002;
100(10):
3545 - 3552.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Cashman, B. Dykstra, I. Clark-Lewis, A. Eaves, and C. Eaves
Changes in the Proliferative Activity of Human Hematopoietic Stem Cells in NOD/SCID Mice and Enhancement of Their Transplantability after In Vivo Treatment with Cell Cycle Inhibitors
J. Exp. Med.,
November 4, 2002;
196(9):
1141 - 1150.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Bug, T. Rossmanith, R. Henschler, L.A. Kunz-Schughart, B. Schroder, M. Kampfmann, M. Kreutz, D. Hoelzer, and O. G. Ottmann
Rho family small GTPases control migration of hematopoietic progenitor cells into multicellular spheroids of bone marrow stroma cells
J. Leukoc. Biol.,
October 1, 2002;
72(4):
837 - 845.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Huygen, O. Giet, V. Artisien, I. Di Stefano, Y. Beguin, and A. Gothot
Adhesion of synchronized human hematopoietic progenitor cells to fibronectin and vascular cell adhesion molecule-1 fluctuates reversibly during cell cycle transit in ex vivo culture
Blood,
September 26, 2002;
100(8):
2744 - 2752.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. B. Mazo, E. J. Quackenbush, J. B. Lowe, and U. H. von Andrian
Total body irradiation causes profound changes in endothelial traffic molecules for hematopoietic progenitor cell recruitment to bone marrow
Blood,
May 13, 2002;
99(11):
4182 - 4191.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Papayannopoulou, G. V. Priestley, B. Nakamoto, V. Zafiropoulos, and L. M. Scott
Molecular pathways in bone marrow homing: dominant role of {alpha}4{beta}1 over {beta}2-integrins and selectins
Blood,
October 15, 2001;
98(8):
2403 - 2411.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. Szilvassy, T. E. Meyerrose, P. L. Ragland, and B. Grimes
Differential homing and engraftment properties of hematopoietic progenitor cells from murine bone marrow, mobilized peripheral blood, and fetal liver
Blood,
October 1, 2001;
98(7):
2108 - 2115.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-P. Levesque, Y. Takamatsu, S. K. Nilsson, D. N. Haylock, and P. J. Simmons
Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor
Blood,
September 1, 2001;
98(5):
1289 - 1297.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Khaldoyanidi, L. Sikora, I. Orlovskaya, V. Matrosova, V. Kozlov, and P. Sriramarao
Correlation between nicotine-induced inhibition of hematopoiesis and decreased CD44 expression on bone marrow stromal cells
Blood,
July 15, 2001;
98(2):
303 - 312.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-F. Zhang, J.-F. Wang, E. Matczak, J. Proper, and J. E. Groopman
Janus kinase 2 is involved in stromal cell-derived factor-1{alpha}-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells
Blood,
June 1, 2001;
97(11):
3342 - 3348.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Hattori, B. Heissig, K. Tashiro, T. Honjo, M. Tateno, J.-H. Shieh, N. R. Hackett, M. S. Quitoriano, R. G. Crystal, S. Rafii, et al.
Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells
Blood,
June 1, 2001;
97(11):
3354 - 3360.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Kollet, A. Spiegel, A. Peled, I. Petit, T. Byk, R. Hershkoviz, E. Guetta, G. Barkai, A. Nagler, and T. Lapidot
Rapid and efficient homing of human CD34+CD38{-}/lowCXCR4+ stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2mnull mice
Blood,
May 15, 2001;
97(10):
3283 - 3291.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Asosingh, U. Günthert, H. De Raeve, I. Van Riet, B. Van Camp, and K. Vanderkerken
A Unique Pathway in the Homing of Murine Multiple Myeloma Cells: CD44v10 Mediates Binding to Bone Marrow Endothelium
Cancer Res.,
April 1, 2001;
61(7):
2862 - 2865.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. Chen, Y. Li, L. Wang, Z. Zhang, D. Lu, M. Lu, and M. Chopp
Therapeutic Benefit of Intravenous Administration of Bone Marrow Stromal Cells After Cerebral Ischemia in Rats
Stroke,
April 1, 2001;
32(4):
1005 - 1011.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Christ, U. Günthert, R. Haas, and M. Zöller
Importance of CD44v7 isoforms for homing and seeding of hematopoietic progenitor cells
J. Leukoc. Biol.,
March 1, 2001;
69(3):
343 - 352.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
T. Papayannopoulou, G. V. Priestley, B. Nakamoto, V. Zafiropoulos, L. M. Scott, and J. M. Harlan
Synergistic mobilization of hemopoietic progenitor cells using concurrent {beta}1 and {beta}2 integrin blockade or {beta}2-deficient mice
Blood,
March 1, 2001;
97(5):
1282 - 1288.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Glimm, I.-H. Oh, and C. J. Eaves
Human hematopoietic stem cells stimulated to proliferate in vitro lose engraftment potential during their S/G2/M transit and do not reenter G0
Blood,
December 15, 2000;
96(13):
4185 - 4193.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Aziz, K. J. Till, M. Zuzel, and J. C. Cawley
Involvement of CD44-hyaluronan interaction in malignant cell homing and fibronectin synthesis in hairy cell leukemia
Blood,
November 1, 2000;
96(9):
3161 - 3167.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. S. Frenette and L. Weiss
Sulfated glycans induce rapid hematopoietic progenitor cell mobilization: evidence for selectin-dependent and independent mechanisms
Blood,
October 1, 2000;
96(7):
2460 - 2468.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. Orschell-Traycoff, K. Hiatt, R. N. Dagher, S. Rice, M. C. Yoder, and E. F. Srour
Homing and engraftment potential of Sca-1+lin- cells fractionated on the basis of adhesion molecule expression and position in cell cycle
Blood,
August 15, 2000;
96(4):
1380 - 1387.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. D. M. Soede, Y. M. Wijnands, M. Kamp, M. A. van der Valk, and E. Roos
Gi and Gq/11 proteins are involved in dissemination of myeloid leukemia cells to the liver and spleen, whereas bone marrow colonization involves Gq/11 but not Gi
Blood,
July 15, 2000;
96(2):
691 - 698.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Peled, O. Kollet, T. Ponomaryov, I. Petit, S. Franitza, V. Grabovsky, M. M. Slav, A. Nagler, O. Lider, R. Alon, et al.
The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34+ cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice
Blood,
June 1, 2000;
95(11):
3289 - 3296.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. J. Cotterell, C. R. Engwerda, and P. M. Kaye
Enhanced Hematopoietic Activity Accompanies Parasite Expansion in the Spleen and Bone Marrow of Mice Infected with Leishmania donovani
Infect. Immun.,
April 1, 2000;
68(4):
1840 - 1848.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. D. S. Iglesia, P. H. Gala, T. Qiu, and M. A. Stepp
Integrin Expression During Epithelial Migration and Restratification in the Tenascin-C-deficient Mouse Cornea
J. Histochem. Cytochem.,
March 1, 2000;
48(3):
363 - 376.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. Hasegawa, T. M. Baldwin, D. Metcalf, and S. J. Foote
Progenitor cell mobilization by granulocyte colony-stimulating factor controlled by loci on chromosomes 2 and 11
Blood,
March 1, 2000;
95(5):
1872 - 1874.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. W. Greenberg, W. G. Kerr, and D. A. Hammer
Relationship between selectin-mediated rolling of hematopoietic stem and progenitor cells and progression in hematopoietic development
Blood,
January 15, 2000;
95(2):
478 - 486.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. B. van Hennik, A. E. de Koning, and R. E. Ploemacher
Seeding Efficiency of Primitive Human Hematopoietic Cells in Nonobese Diabetic/Severe Combined Immune Deficiency Mice: Implications for Stem Cell Frequency Assessment
Blood,
November 1, 1999;
94(9):
3055 - 3061.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Glimm and C.J. Eaves
Direct Evidence for Multiple Self-Renewal Divisions of Human In Vivo Repopulating Hematopoietic Cells in Short-Term Culture
Blood,
October 1, 1999;
94(7):
2161 - 2168.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. D. Zanjani, A. W. Flake, G. Almeida-Porada, N. Tran, and T. Papayannopoulou
Homing of Human Cells in the Fetal Sheep Model: Modulation by Antibodies Activating or Inhibiting Very Late Activation Antigen-4-Dependent Function
Blood,
October 1, 1999;
94(7):
2515 - 2522.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. C. Fisher, J. D. Lovelock, and E. W. Scott
A Critical Role for PU.1 in Homing and Long-Term Engraftment by Hematopoietic Stem Cells in the Bone Marrow
Blood,
August 15, 1999;
94(4):
1283 - 1290.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. M. Pilarski, E. Pruski, J. Wizniak, D. Paine, K. Seeberger, M. J. Mant, C. B. Brown, and A. R. Belch
Potential Role for Hyaluronan and the Hyaluronan Receptor RHAMM in Mobilization and Trafficking of Hematopoietic Progenitor Cells
Blood,
May 1, 1999;
93(9):
2918 - 2927.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. J. Quesenberry and P. S. Becker
Stem cell homing: Rolling, crawling, and nesting
PNAS,
December 22, 1998;
95(26):
15155 - 15157.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Simpson, J. Reiland, S. R. Burger, L. T. Furcht, A. P. Spicer, T. R. Oegema Jr., and J. B. McCarthy
Hyaluronan Synthase Elevation in Metastatic Prostate Carcinoma Cells Correlates with Hyaluronan Surface Retention, a Prerequisite for Rapid Adhesion to Bone Marrow Endothelial Cells
J. Biol. Chem.,
May 18, 2001;
276(21):
17949 - 17957.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
