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Blood, Vol. 92 No. 4 (August 15), 1998:
pp. 1317-1323
Aberrant and Unstable Expression of Immunoglobulin Genes in
Persons Infected With Human Immunodeficiency Virus
Alberto Bessudo,
Laura Rassenti,
Diane Havlir,
Douglas Richman,
Ellen Feigal, and
Thomas J. Kipps
From the Divisions of Hematology/Oncology and Infectious Diseases,
Department of Medicine, University of California, San Diego, La Jolla,
CA; and the National Cancer Institute, Bethesda, MD.
We examined the IgM VH gene subgroup use-distribution in
serial blood samples of 37 human immunodeficiency virus (HIV)-infected patients and a group of HIV-seronegative healthy adults. The IgM VH gene repertoires of healthy adults were relatively
similar to one another and were stable over time. In contrast,
individuals infected with HIV had IgM VH gene repertoires
that were significantly more heterogeneous and unstable. Persons at
early stages of HIV infection generally had abnormal expression levels
of Ig VH3 genes and frequently displayed marked
fluctuations in the relative expression levels of this VH
gene subgroup over time. In contrast, persons with established acquired
immunodeficiency syndrome (AIDS) had a significantly lower incidence of
abnormalities in Ig VH3 expression levels, although
continued to display abnormalities and instability in the expression
levels of the smaller Ig VH gene subgroups. Moreover, the
skewing and/or fluctuations in the expressed-IgM VH
gene repertoire appeared greatest for persons at earlier stages of HIV
infection. These studies show that persons infected with HIV have
aberrant and unstable expression of immunoglobulin genes suggestive of
a high degree humoral immune dysregulation and ongoing humoral immune
responses to HIV-associated antigens and superantigens.
© 1998 by The American Society of Hematology.
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