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Blood, Vol. 92 No. 6 (September 15), 1998:
pp. 1887-1897
Eotaxin Modulates Myelopoiesis and Mast Cell Development From
Embryonic Hematopoietic Progenitors
Elizabeth J. Quackenbush,
Barry K. Wershil,
Vincent Aguirre, and
Jose-Carlos Gutierrez-Ramos
From The Center for Blood Research, the Department of Genetics,
Harvard Medical School, and the Division of Clinical Genetics, The
Children's Hospital, the Combined Program in Pediatric
Gastroenterology and Nutrition, The Children's Hospital and
Massachusetts General Hospital, and the Division of Experimental
Pathology, Beth Israel Deaconess Hospital, Boston, MA; and Millennium
Pharmaceuticals, Inc, Cambridge, MA.
Eotaxin is a potent chemoattractant for eosinophils during
inflammation and allergic reactions in the adult, but its role in the
embryonic development of the hematopoietic system has not been
examined. We report here that eotaxin and its receptor, CCR-3, are
expressed by embryonic tissues responsible for blood development, such
as fetal liver (FL), yolk sac (YS), and peripheral blood. We found that
eotaxin acts synergistically with stem cell factor to accelerate the
differentiation of embryonic mast cell progenitors, and this response
can be suppressed by pertussis toxin, an inhibitor of
chemokine-induced signaling through Gi protein and chemotaxis. Eotaxin promotes the differentiation of fetal mast cell
progenitors into differentiated mast cells as defined by the expression
of mast cell specific proteases. Furthermore, in combination with stem
cell factor (SCF), it promotes the growth of Mac-1+
myeloid cells from embryonic progenitors. These studies suggest that
eotaxin may be involved in the growth of granulocytic progenitors and
the differentiation and/or function of mast cells during
embryogenesis and/or pathological conditions that induce high
levels of eotaxin, such as allergic responses.
© 1998 by The American Society of Hematology.
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