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Blood, Vol. 92 No. 8 (October 15), 1998:
pp. 2613-2628
The Sialomucin CD164 (MGC-24v) Is an Adhesive Glycoprotein
Expressed by Human Hematopoietic Progenitors and Bone Marrow
Stromal Cells That Serves as a Potent Negative Regulator of
Hematopoiesis
Andrew C.W. Zannettino,
Hans-Jörg Bühring,
Silvana Niutta,
Suzanne M. Watt,
M. Ann Benton, and
Paul J. Simmons
From the Hanson Centre for Cancer Research, Matthew Roberts
Laboratory, Institute Of Medical and Veterinary Science, Adelaide,
Australia; the Medizinische Universitatsklinik II, University Of
Tübingen, Tübingen, Germany; and MRC Molecular Haematology,
Institute Of Molecular Medicine, The John Radcliffe Hospital, Oxford,
UK.
Mucin-like molecules represent an emerging family of cell surface
glycoproteins expressed by cells of the hematopoietic system. We report
the isolation of a cDNA clone that encodes a novel transmembrane isoform of the mucin-like glycoprotein MGC-24, expressed by both hematopoietic progenitor cells and elements of the bone marrow (BM)
stroma. This molecule was clustered as CD164 at the recent workshop on
human leukocyte differentiation antigens. CD164 was identified using a
retroviral expression cloning strategy and two novel monoclonal
antibody (MoAb) reagents, 103B2/9E10 and 105.A5. Both antibodies
detected CD164/MGC-24v protein expression by BM stroma and
subpopulations of the CD34+ cells, which include the
majority of clonogenic myeloid (colony-forming unit-granulocyte-macrophage [CFU-GM]) and erythroid (blast-forming unit-erythroid [BFU-E]) progenitors and the hierarchically more primitive precursors (pre-CFU). Biochemical and functional
characterization of CD164 showed that this protein represents a
homodimeric molecule of approximately 160 kD. Functional studies
demonstrate a role for CD164 in the adhesion of hematopoietic
progenitor cells to BM stromal cells in vitro. Moreover, antibody
ligation of CD164 on primitive hematopoietic progenitor cells
characterized by the cell surface phenotype
CD34BRIGHTCD38 results in the decreased
recruitment of these cells into cell cycle, suggesting that CD164
represents a potent signaling molecule with the capacity to suppress
hematopoietic cell proliferation.
© 1998 by The American Society of Hematology.
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